WEKO3
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Acyltransferase in Rat Salivary Glands for Polyunsaturated Long-Chain Acyl-CoAs", "subitem_title_language": "en"}]}, "item_type_id": "10002", "owner": "21", "path": ["351"], "permalink_uri": "https://asahi-u.repo.nii.ac.jp/records/5231", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-02-10"}, "publish_date": "2017-02-10", "publish_status": "0", "recid": "5231", "relation": {}, "relation_version_is_last": true, "title": ["ラット顎下腺および耳下腺ミクロソームの1-アシル-sn-グリセロ-3-ホスホコリンアシルトランスフェラーゼの多価不飽和脂肪酸アシル-CoAに着目した基質特異性"], "weko_shared_id": -1}
ラット顎下腺および耳下腺ミクロソームの1-アシル-sn-グリセロ-3-ホスホコリンアシルトランスフェラーゼの多価不飽和脂肪酸アシル-CoAに着目した基質特異性
https://asahi-u.repo.nii.ac.jp/records/5231
https://asahi-u.repo.nii.ac.jp/records/5231f041ad4c-b3f2-4bf8-bb40-8456d4abd3cc
名前 / ファイル | ライセンス | アクション |
---|---|---|
gifushika343_105109_2008 (528.1 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-02-10 | |||||
タイトル | ||||||
タイトル | ラット顎下腺および耳下腺ミクロソームの1-アシル-sn-グリセロ-3-ホスホコリンアシルトランスフェラーゼの多価不飽和脂肪酸アシル-CoAに着目した基質特異性 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Substrate Specificity of Microsomal 1-Acyl-sn-glycero-3-phosphocholine Acyltransferase in Rat Salivary Glands for Polyunsaturated Long-Chain Acyl-CoAs | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 1-アシル-sn-グリセロ-3-ホスホコリンアシルトランスフェラーゼ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | アシル-CoA基質特異性 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ホスファチジルコリン | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 唾液腺 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 顎下腺 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 基質特異性 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 耳下腺 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 不飽和脂肪酸 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ミクロソーム | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Wistarラット | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ラット | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | 1-acyl-sn-glycero-3-phosphocholine acyltransferase activity | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Acyl Coenzyme A | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | 1-Acylglycerophosphocholine O-Acyltransferase | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Phosphatidylcholines | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | salivary glands | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
亀山, 泰永
× 亀山, 泰永× 神谷, 真子× 八代, 耕児× 藤田, 厚 |
|||||
著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 5691 | |||||
姓名 | KAMEYAMA, YASUNAGA | |||||
著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 8629 | |||||
姓名 | KAMIYA, MASAKO | |||||
著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 6806 | |||||
姓名 | YASHIRO, KOJI | |||||
著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 8734 | |||||
姓名 | FUJITA, ATSUSHI | |||||
所属 | ||||||
値 | 朝日大学歯学部口腔構造機能発育学講座口腔生化学分野 Department of Oral Biochemistry, Division of Oral Structure, Function and Development, Asahi University School of Dentistry |
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所属 | ||||||
値 | 朝日大学歯学部口腔構造機能発育学講座口腔生化学分野 Department of Oral Biochemistry, Division of Oral Structure, Function and Development, Asahi University School of Dentistry |
|||||
所属 | ||||||
値 | 朝日大学歯学部口腔構造機能発育学講座口腔生化学分野 Department of Oral Biochemistry, Division of Oral Structure, Function and Development, Asahi University School of Dentistry |
|||||
所属 | ||||||
値 | 朝日大学歯学部口腔構造機能発育学講座口腔生化学分野 Department of Oral Biochemistry, Division of Oral Structure, Function and Development, Asahi University School of Dentistry |
|||||
書誌情報 |
岐阜歯科学会雑誌 en : The Journal of Gifu Dental Society 巻 34, 号 3, p. 105-109, 発行日 2008-02-20 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | ラット顎下腺および耳下腺ミクロソームの1-アシル-sn-グリセロ-3-ホスホコリンアシルトランスフェラーゼの基質特異性を検討した。顎下腺の酵素は、5,8,11,14,17-エイコサペンタエノイル-CoAに対して一番活性が高く、次いで11,14,17-エイコサトリエノイル-、アラキドノイル-、オレオイル-CoAの順であった。一方、飽和アシル-CoAに対する基質特異性は不飽和アシル-CoAのそれより低かった。耳下腺では、5,8,11,14,17-エイコサペンタエノイル-CoAに対して一番活性が高く、次いで11,14,17-エイコサトリエノイル-、γ-リノレノイル-、アラキドノイル-CoAの順であった。顎下腺ミクロソームの1-アシル-sn-グリセロ-3-ホスホコリンアシルトランスフェラーゼ活性は耳下腺のそれより2-5倍高かった。この酵素は、トランス型および分枝鎖型アシル-CoAに対しても高い活性を示した。顎下腺、耳下腺における酵素の比活性の解析から、本酵素は炭化水素鎖長:18以上、二重結合の数:3-5個のアシル-CoAに対して高活性を示した。これらの結果は、唾液腺の1-アシル-sn-グリセロ-3-ホスホコリンアシルトランスフェラーゼがエイコサノイドに関連したアシル-CoAを良い基質にすることが示唆された。このことは、ミクロソームの再アシル化系酵素がホスファチジルコリン内にエイコサノイド前駆物質を蓄積するのに重要であると考えられる。 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The substrate specificities of microsomal 1-acyl-sn-glycero-3-phosphocholine acyltransferase were observed in the rat submandibular and parotid glands. The most preferable substrate in the submandibular gland was 5,8,11,14,17-eicosapentaenoyl-CoA followed by 11,14,17-eicosatrienoyl-, arachidonoyl- and oleoyl-CoAs. However, the specificity for saturated acyl-CoAs was lower than those for the polyunsaturated acyl-CoAs. In the parotid gland, the highest enzyme activity was also for 5,8,11,14,17-eicosapentaenoyl-CoA followed by 11,14,17-eicosatrienoyl-,γ-linolenoyl- and arachidonoyl-CoAs. These specificities also closely resemble those of the liver. When1-acyl-snglycero-3-phosphocholine acyltransferase activity is compared among the salivary glands and liver, activity in the submandibular gland was 2-5 times and about two times higher than those in the parotid gland and liver, respectively. 1-Acyl-sn-glycero-3-phosphocholine acyltransferase also utilized acyl-CoAs having trans-unsaturated such as elaidoyl- and linoelaidoyl-CoAs or branched chain acyl-CoA like 13-methyltetradecanoyl-CoA as substrates. Furthermore,the activities of trans-unsaturated acyl-CoAs were very similar to those of cis-unsaturated acyl-CoAs. However, it is still not clear whether the reacylation enzyme protein recognizes the cis and trans configurations. From the analysis of relative activities, 1-acyl-sn-glycero-3-phosphocholine acyltransferase from both salivary glands preferred a substrate with an acyl chain length more than 18 carbon atoms with more than 3-5 double bonds in the acyl chain. These findings suggest that eicosanoid-related acyl-CoAs are good substrate for 1-acyl-sn-glycero-3-phosphocholine acyltransferase in salivary glands. Thus, the microsomal reacylation enzyme may play a role in the storage of eicosanoid precursors for metabolism into phosphatidylcholine. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0385-0072 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00053070 | |||||
論文ID(NAID) | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | NAID | |||||
関連識別子 | 110007405493 | |||||
医中誌文献番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | ICHUSHI | |||||
関連識別子 | 2008166298 | |||||
フォーマット | ||||||
値 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |