{"created":"2023-06-23T12:19:10.357210+00:00","id":10018,"links":{},"metadata":{"_buckets":{"deposit":"d713740d-8b0f-4719-b46e-9a63412f2fec"},"_deposit":{"created_by":19,"id":"10018","owners":[19],"pid":{"revision_id":0,"type":"depid","value":"10018"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00010018","sets":["64:123"]},"author_link":["13492"],"item_10_creator_30":{"attribute_name":"教員氏名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河野, 哲"}],"nameIdentifiers":[{"nameIdentifier":"13492","nameIdentifierScheme":"WEKO"}]}]},"item_10_date_36":{"attribute_name":"発行又は発表の年月","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-07"}]},"item_10_text_38":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_text_value":"0022-0345"}]},"item_10_textarea_29":{"attribute_name":"業績分類","attribute_value_mlt":[{"subitem_textarea_value":"学術雑誌論文"}]},"item_10_textarea_31":{"attribute_name":"発行、発表雑誌等、又は発表学会等の名称","attribute_value_mlt":[{"subitem_textarea_value":"Journal of Dental Reseach"}]},"item_10_textarea_32":{"attribute_name":"巻","attribute_value_mlt":[{"subitem_textarea_value":"97"}]},"item_10_textarea_33":{"attribute_name":"号","attribute_value_mlt":[{"subitem_textarea_value":"7"}]},"item_10_textarea_34":{"attribute_name":"掲載ページ","attribute_value_mlt":[{"subitem_textarea_value":"795-802"}]},"item_10_textarea_35":{"attribute_name":"単著、共著の別","attribute_value_mlt":[{"subitem_textarea_value":"共著"}]},"item_10_textarea_42":{"attribute_name":"概要","attribute_value_mlt":[{"subitem_textarea_value":"高リスクヒトパピローマウイルス（HPV）は口腔および咽頭癌（OPC）の主要な危険因子であるが、HPVがOPCを促進する詳細なメカニズムは理解されていない。M1B（FoxM1B）は、細胞周期の進行および腫瘍形成に不可欠なオンコジーンであり、多くの腫瘍において異常に過剰発現している。HPVタイプ16（HPV-16）E6が、部分的にGRHL2を介してヒト口腔ケラチノサイト（HOK）および扁桃上皮細胞（TEC）にFoxM1Bを誘導、HPV-16が部分的にGRHL2転写活性によりFoxM1Bを誘導し、口腔咽頭癌発症にFoxM1Bレベルの上昇が必要であることを示した。"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"other","resourceuri":"http://purl.org/coar/resource_type/c_1843"}]},"item_title":"Human Papillomavirus 16 E6 Induces FoxM1B in Oral Keratinocytes through GRHL2","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Human Papillomavirus 16 E6 Induces FoxM1B in Oral Keratinocytes through GRHL2"}]},"item_type_id":"10","owner":"19","path":["123"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-01-09"},"publish_date":"2019-01-09","publish_status":"0","recid":"10018","relation_version_is_last":true,"title":["Human Papillomavirus 16 E6 Induces FoxM1B in Oral Keratinocytes through GRHL2"],"weko_creator_id":"19","weko_shared_id":-1},"updated":"2023-06-23T13:37:06.854076+00:00"}