{"created":"2023-06-23T12:19:44.155828+00:00","id":10827,"links":{},"metadata":{"_buckets":{"deposit":"8e5f05bb-3aab-44df-8390-90b69a6ecebf"},"_deposit":{"created_by":21,"id":"10827","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"10827"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00010827","sets":["46:348:431"]},"author_link":["8585","4128","13295","4126","13296","4134","492","13294","3971","4257","3802","13292","50","14076"],"item_10002_biblio_info_77":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"173","bibliographicPageStart":"165","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"岐阜歯科学会雑誌"},{"bibliographic_title":"The Journal of Gifu Dental Society","bibliographic_titleLang":"en"}]}]},"item_10002_description_80":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、インプラント周囲の骨造成において、炭酸含有アパタイト（CA）を担体としbFGFを添加した複合体の有効性を検討した。インプラント体は3.0×8.0mmチタン製（integra-CP®：Bicon 社）を用いた。CAは土井らの方法に準じて合成したものを用いた。CA粉末と250～500μm径に調節した顆粒糖とを1：1で混合し、円柱状に金型成形し200Mpa静水圧処理した。得られた円柱状CA多孔体を蒸留水中に1時間浸漬して糖を溶出させた。乾燥後、700℃まで昇温し、この温度で1時間保持して焼結CA多孔体を作製した。多孔体を破砕し篩にかけ、600～1000㎛のCA多孔体を得た。bFGF（フィブラストスプレー®：科研製薬）は250㎍を1mlの生理食塩水に溶解し使用した。bFGF-CA複合体は1mlbFGF溶液をCAに含浸させ使用した。雄性ビーグル犬3頭を用い、実験部位は下顎両側の第3、第4前臼歯部とした。全身麻酔下で第3、第4前臼歯部に歯肉溝内切開を加え剥離後、分割抜歯を行い縫合した。抜歯後12週に、全身麻酔下で第3、第4前臼歯部を全層弁で剥離後、インプラント窩を作製した。インプラント窩頬側に横3.0mm縦7.0mmの骨欠損を作製した後、インプラント体を埋入した。術後8週に屠殺後、試料を採取し4％PFAで固定した。マイクロCTにて骨塩量（BMD）計測後、樹脂切片を作製し組織学的評価及び新生骨量、新生骨高さ、CA残存率の計測を行った。CA顆粒の残存は認められたが、FGF+CA群で著明な骨造成が観察された。CAによって骨新生のスペースが確保されたこと、bFGFによって骨新生が促進されたことによると考えられる。また、FGF+CA群ではCA群と比較してCA残存率は有意に低かった。bFGFがCAの吸収、骨への置換を促進しているものと思われる。","subitem_description_type":"Abstract"}]},"item_10002_description_81":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"In the study described here, the authors investigated the efficacy of a complex in which carbonate-containing apatite (CA) was used as a carrier and basic fibroblast growth factor (bFGF) was added in the augmentation of bone surrounding implants. The implant body used was a titanium unit measuring 3.0 × 8.0mm. CA was synthesized as described by Doi et al. CA powder and granulated sugar adjusted to diameters of 250‒500 μm were mixed at a ratio of 1:1, placed in a metal die to form a cylindrical shape, and processed at a hydrostatic pressure of 200 MPa. The resulting cylindrical CA porous substance was immersed in distilled water for one hour to elute the sugar. After the substance was dried, the temperature was increased to 700℃ and the substance was left at that temperature for one hour to produce a sintered CA porous substance. The porous substance was then fragmented and run through a sieve to obtain CA porous substances with pore sizes measuring 600‒1,000μm. bFGF (Fiblast Spray®, Kaken Pharmaceutical Co., Ltd.) was used by dissolving 250μg in 1ml of normal saline. The bFGF-CA complex was used by impregnating 1ml of bFGF into CA. Three male beagle dogs were used in the study, with the experiment site being the bilateral mandibular third and fourth premolars. Under general anesthesia, an incision was made in the gingival sulcus of the third and fourth premolars. After the gingival sulcus was peeled away, the molars were split and extracted, and the incision was closed. Twelve weeks post-extraction, a full-thickness flap was peeled back from the third and fourth premolars under general anesthesia, and an implant fossa was created. A bone defect measuring 3.0mm across and 7.0mm high was created on the buccal side of the implant fossa, after which the implant body was placed. Eight weeks after surgery, the dogs were sacrificed and specimens were extracted and fixed in 4% perfluoroalkoxy alkane. The bone mineral content was measured using microcomputed tomography, resin sections were created, and histological evaluation was carried out. Measurements were also taken of the amount of new bone, the height of the new bone, and the rate of residual CA. Remnant CA granules were observed, but obvious bone augmentation was seen in the fibroblast growth factor (FGF) + CA group. It is possible that this was because CA assured space for new bone growth and bFGF promoted this growth. Moreover, in the FGF + CA group, the rate of residual CA was significantly lower than that in the CA group. It is possible that bFGF promotes the absorption of CA and the substitution of CA for bone.","subitem_description_type":"Other"}]},"item_10002_full_name_75":{"attribute_name":"著者別名","attribute_value_mlt":[{"affiliations":[{"affiliationNames":[{"affiliationName":"朝日大学歯学部","lang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"33703","nameIdentifierScheme":"kakenhi","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=33703"}]}],"familyNames":[{"familyName":"向井","familyNameLang":"ja"},{"familyName":"MUKAI","familyNameLang":"en"}],"givenNames":[{"givenName":"景祐","givenNameLang":"ja"},{"givenName":"KEISUKE","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3802","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000342905777","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000342905777"}],"names":[{"name":"向井, 景祐","nameLang":"ja"},{"name":"MUKAI, 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