{"created":"2023-06-23T12:20:01.402633+00:00","id":11232,"links":{},"metadata":{"_buckets":{"deposit":"1d1ddba6-38ab-4702-94bf-884155c3454c"},"_deposit":{"created_by":19,"id":"11232","owners":[19],"pid":{"revision_id":0,"type":"depid","value":"11232"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00011232","sets":["64:123"]},"author_link":["14442"],"item_10_creator_30":{"attribute_name":"教員氏名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"竹内, 綾"}],"nameIdentifiers":[{"nameIdentifier":"14442","nameIdentifierScheme":"WEKO"}]}]},"item_10_date_36":{"attribute_name":"発行又は発表の年月","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-06"}]},"item_10_textarea_29":{"attribute_name":"業績分類","attribute_value_mlt":[{"subitem_textarea_value":"学術雑誌論文"}]},"item_10_textarea_31":{"attribute_name":"発行、発表雑誌等、又は発表学会等の名称","attribute_value_mlt":[{"subitem_textarea_value":"岐阜歯科学会雑誌"}]},"item_10_textarea_32":{"attribute_name":"巻","attribute_value_mlt":[{"subitem_textarea_value":"46"}]},"item_10_textarea_33":{"attribute_name":"号","attribute_value_mlt":[{"subitem_textarea_value":"1"}]},"item_10_textarea_34":{"attribute_name":"掲載ページ","attribute_value_mlt":[{"subitem_textarea_value":"27-39"}]},"item_10_textarea_35":{"attribute_name":"単著、共著の別","attribute_value_mlt":[{"subitem_textarea_value":"共著"}]},"item_10_textarea_42":{"attribute_name":"概要","attribute_value_mlt":[{"subitem_textarea_value":"SDラットから自然発生する軟骨石灰化不全(CCI)ラットの頭蓋底軟骨結合に着目し、SDラットとCCIラットを形態学的ならびに分子生物学的に比較検討した.マイクロCT画像,Hematoxyline・Eosin染色,Safranin O Fast Green染色において、軟骨幅の増大が認められた.また,BrdU免疫染色において、軟骨細胞の過剰増殖が認められた.軟骨細胞の増殖に関連するIhh mRNAとGli mRNAの相対的定量解析とin situ hybridizatioにおいて,Ｇｌｉ１　ｍＲＮＡの過剰発現と分布異常が認められた.軟骨細胞のアポトーシスに関連するDMP1 mRNAのISHにおいて、肥大層軟骨細胞で発現の減少が認められた.以上から,CCIラットの形態異常は軟骨細胞の過剰増殖と肥大層軟骨細胞の未成熟によるもので、その発症機序には、Gli1 mRNAとDMP1 mRNAの発現と分布異常が関係している可能性が考えられた."}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"other","resourceuri":"http://purl.org/coar/resource_type/c_1843"}]},"item_title":"軟骨石灰化不全ラットにおける頭蓋底軟骨結合の形態学的ならびに分子生物学的検索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"軟骨石灰化不全ラットにおける頭蓋底軟骨結合の形態学的ならびに分子生物学的検索"}]},"item_type_id":"10","owner":"19","path":["123"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-11-21"},"publish_date":"2019-11-21","publish_status":"0","recid":"11232","relation_version_is_last":true,"title":["軟骨石灰化不全ラットにおける頭蓋底軟骨結合の形態学的ならびに分子生物学的検索"],"weko_creator_id":"19","weko_shared_id":-1},"updated":"2023-06-23T13:21:46.203660+00:00"}