{"created":"2023-06-23T12:20:22.435634+00:00","id":11668,"links":{},"metadata":{"_buckets":{"deposit":"109c0e90-576b-49cc-81d9-5d28dd7a0988"},"_deposit":{"created_by":19,"id":"11668","owners":[19],"pid":{"revision_id":0,"type":"depid","value":"11668"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00011668","sets":["64:123"]},"author_link":["14899"],"item_10_creator_30":{"attribute_name":"教員氏名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"引頭, 毅"}],"nameIdentifiers":[{"nameIdentifier":"14899","nameIdentifierScheme":"WEKO"}]}]},"item_10_date_36":{"attribute_name":"発行又は発表の年月","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-11-17"}]},"item_10_textarea_29":{"attribute_name":"業績分類","attribute_value_mlt":[{"subitem_textarea_value":"学会発表"}]},"item_10_textarea_31":{"attribute_name":"発行、発表雑誌等、又は発表学会等の名称","attribute_value_mlt":[{"subitem_textarea_value":"The JADR 2018/ 66th Japanese Division Meeting 2018"}]},"item_10_textarea_35":{"attribute_name":"単著、共著の別","attribute_value_mlt":[{"subitem_textarea_value":"共同発表"}]},"item_10_textarea_42":{"attribute_name":"概要","attribute_value_mlt":[{"subitem_textarea_value":"自己免疫性唾液腺炎（AS）はシェーグレン症候群やIgG4関連疾患等で認められる慢性炎症である．ASにおける自然免疫系の役割,特にToll様受容体のシグナル伝達を担うMyD88に着目して研究を行った．二種のASモデルマウスでMyD88を欠失させたところいずれでもASの発症が強力に抑制されていた．最も顕著であったのは高内皮細静脈（HEV）の形成抑制効果であった。HEV形成に関与するLTβRシグナルを調べたところ，MyD88欠損によってシグナルが減弱することが分かった．"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"other","resourceuri":"http://purl.org/coar/resource_type/c_1843"}]},"item_title":"MyD88 signaling causes formation of high endothelial venules to develop autoimmune sialadenitis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"MyD88 signaling causes formation of high endothelial venules to develop autoimmune sialadenitis"}]},"item_type_id":"10","owner":"19","path":["123"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-11-26"},"publish_date":"2019-11-26","publish_status":"0","recid":"11668","relation_version_is_last":true,"title":["MyD88 signaling causes formation of high endothelial venules to develop autoimmune sialadenitis"],"weko_creator_id":"19","weko_shared_id":-1},"updated":"2023-06-23T13:16:54.406576+00:00"}