{"created":"2023-06-23T12:20:22.523575+00:00","id":11670,"links":{},"metadata":{"_buckets":{"deposit":"66fbd69f-0726-4885-aac9-85b1a2ee1d82"},"_deposit":{"created_by":19,"id":"11670","owners":[19],"pid":{"revision_id":0,"type":"depid","value":"11670"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00011670","sets":["64:123"]},"author_link":["14901"],"item_10_creator_30":{"attribute_name":"教員氏名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"引頭, 毅"}],"nameIdentifiers":[{"nameIdentifier":"14901","nameIdentifierScheme":"WEKO"}]}]},"item_10_date_36":{"attribute_name":"発行又は発表の年月","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-11-17"}]},"item_10_textarea_29":{"attribute_name":"業績分類","attribute_value_mlt":[{"subitem_textarea_value":"学会発表"}]},"item_10_textarea_31":{"attribute_name":"発行、発表雑誌等、又は発表学会等の名称","attribute_value_mlt":[{"subitem_textarea_value":"The JADR 2018/ 66th Japanese Division Meeting 2018"}]},"item_10_textarea_35":{"attribute_name":"単著、共著の別","attribute_value_mlt":[{"subitem_textarea_value":"共同発表"}]},"item_10_textarea_42":{"attribute_name":"概要","attribute_value_mlt":[{"subitem_textarea_value":"口腔の自然免疫機構で重要な役割を果たす抗菌ペプチドLL-37は抗菌作用のみならず，強いLPS中和作用を有している．本研究ではヒト歯肉線維芽細胞においてLL-37がPorphyromonas gingivalis由来のLPSを中和する作用の一環として，Toll様受容体関連遺伝子の発現を変化させることを見出した．特に，TLRシグナルを負に制御するレギュレータの発現を上昇させる効果があることが分かったのでその詳細について報告した．"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"other","resourceuri":"http://purl.org/coar/resource_type/c_1843"}]},"item_title":"The antimicrobial peptide LL-37 exerts regulatory effects on expression of Toll-like receptor-associated genes in human gingival fibroblasts","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The antimicrobial peptide LL-37 exerts regulatory effects on expression of Toll-like receptor-associated genes in human gingival fibroblasts"}]},"item_type_id":"10","owner":"19","path":["123"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-11-26"},"publish_date":"2019-11-26","publish_status":"0","recid":"11670","relation_version_is_last":true,"title":["The antimicrobial peptide LL-37 exerts regulatory effects on expression of Toll-like receptor-associated genes in human gingival fibroblasts"],"weko_creator_id":"19","weko_shared_id":-1},"updated":"2023-06-23T13:16:53.107398+00:00"}