{"created":"2023-06-23T12:20:46.252836+00:00","id":12200,"links":{},"metadata":{"_buckets":{"deposit":"f617ce8f-b28f-48f0-bf1c-d19f57779cb4"},"_deposit":{"created_by":21,"id":"12200","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"12200"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00012200","sets":["46:348:448"]},"author_link":["3930","3933"],"item_10002_biblio_info_77":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"122","bibliographicPageStart":"115","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"岐阜歯科学会雑誌"},{"bibliographic_title":"The Journal of Gifu Dental Society","bibliographic_titleLang":"en"}]}]},"item_10002_description_80":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"自然免疫は微生物に対する防御ならびに炎症反応の開始に重要な役割を果たす。抗菌ペプチドは進化的に保存された自然免疫の1つである。何百もの抗菌ペプチドが好中球や上皮細胞より合成され存在する。中でもヒトcathelicidinペプチドのLL-37は抗菌特性に加えて、多様な免疫調節機能を有する。近年ではLL-37が乾癬や全身性エリテマトーデスなどの自己免疫疾患、またアテローム性動脈硬化症や歯周病といった炎症性疾患の病態に関与していることが明らかにされている。この総説ではLL-37の自然免疫における役割、さらには自己免疫疾患および炎症性疾患への関与について近年の知見を報告する。","subitem_description_type":"Abstract"}]},"item_10002_description_81":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The innate immune system plays an important role in the defense against microbes and initiation of inflammatory responses. Antimicrobial peptides are evolutionarily conserved defense mechanisms. Numerous antimicrobial peptides are synthesized from neutrophils and epithelial cells. Among these, the human cathelicidin peptide LL-37 has immunomodulatory roles in addition to its antibacterial functions. Recently, LL-37 has been found to be involved in the pathogenesis of autoimmune diseases, such as psoriasis and systemic lupus erythematosus, and inflammatory diseases, including atherosclerosis and periodontal disease. In this review, we report recent findings regarding the role of LL-37 in innate immune response and its involvement in autoimmune and inflammatory diseases. ","subitem_description_type":"Other"}]},"item_10002_full_name_75":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"3933","nameIdentifierScheme":"WEKO"}],"names":[{"name":"INOMATA, MEGUMI"}]}]},"item_10002_heading_98":{"attribute_name":"見出し","attribute_value_mlt":[{"subitem_heading_banner_headline":"総説","subitem_heading_language":"ja"},{"subitem_heading_banner_headline":"REVIEW ARTICLE","subitem_heading_language":"en"}]},"item_10002_radio_89":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_radio_item":"application/pdf"}]},"item_10002_source_id_82":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2433-0191","subitem_source_identifier_type":"ISSN"}]},"item_10002_source_id_84":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053070","subitem_source_identifier_type":"NCID"}]},"item_10002_textarea_76":{"attribute_name":"所属","attribute_value_mlt":[{"subitem_textarea_value":"朝日大学口腔感染医療学講座口腔微生物学分野\nDepartment of Oral Microbiology, Division of Oral Infections and Health Sciences, Asahi University School of Dentistry"}]},"item_10002_version_type_95":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"猪俣, 恵"}],"nameIdentifiers":[{"nameIdentifier":"3930","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000017728337","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000017728337"},{"nameIdentifier":"40553798","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40553798"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-30"}],"displaytype":"detail","filename":"gifushika463_115122_2020.pdf","filesize":[{"value":"465.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"gifushika463_115122_2020","url":"https://asahi-u.repo.nii.ac.jp/record/12200/files/gifushika463_115122_2020.pdf"},"version_id":"eb326049-3179-4656-bd1a-cc9747d68660"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"抗菌ペプチド","subitem_subject_scheme":"Other"},{"subitem_subject":"LL-37","subitem_subject_scheme":"Other"},{"subitem_subject":"自然免疫","subitem_subject_scheme":"Other"},{"subitem_subject":"自己免疫疾患","subitem_subject_scheme":"Other"},{"subitem_subject":"LL-37","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"antimicrobial peptide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"innate immunity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"autoimmune diseases","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"抗菌ペプチドLL-37の自然免疫における役割と自己免疫疾患および炎症性疾患への関与","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗菌ペプチドLL-37の自然免疫における役割と自己免疫疾患および炎症性疾患への関与"},{"subitem_title":"Role of the antibacterial peptide LL-37 in innate immunity, and its involvement in autoimmune and inflammatory diseases","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"21","path":["448"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-03-28"},"publish_date":"2020-03-28","publish_status":"0","recid":"12200","relation_version_is_last":true,"title":["抗菌ペプチドLL-37の自然免疫における役割と自己免疫疾患および炎症性疾患への関与"],"weko_creator_id":"21","weko_shared_id":-1},"updated":"2023-09-15T06:04:28.731198+00:00"}