{"created":"2023-06-23T12:21:56.664834+00:00","id":13702,"links":{},"metadata":{"_buckets":{"deposit":"2dc76d20-53a3-45cc-9f3d-b5b244a8a022"},"_deposit":{"created_by":21,"id":"13702","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"13702"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00013702","sets":["46:190:416"]},"author_link":["549","3788"],"item_10002_biblio_info_77":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-02-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"290","bibliographicPageStart":"281","bibliographicVolumeNumber":"28","bibliographic_titles":[{"bibliographic_title":"岐阜歯科学会雑誌"},{"bibliographic_title":"The journal of Gifu Dental Society","bibliographic_titleLang":"en"}]}]},"item_10002_description_80":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"リン酸カルシウム化合物は安全性に富みここ20年来、歯科および医科領域において生体材料として用いられてきている。実際の応用いおいては合成後の粉末状体では臨床価値も乏しく、また、飛散化した結晶、もしくは微細化した粉末は、炎症所見の一つである。マクロファージにより貧喰されることが知られている。これらを回避するするために種々の方法でリン酸カルシウム化合物の微結晶の飛散化を防止している。その方法の一つとして高温加熱して各微結晶を融合（焼結）する方法が利用されている。当然ながら、焼結に用いられるリン酸カルシウムは最低でも1000℃程度の温度で安定であることが望まれ、水酸化アパタイト、β-リン酸三カルシウム、およびこれら2相の混合体が焼結材料として用いられ、顆粒、緻密体および多孔体のものが作製されている。また、種々のリン酸カルシウム化合物の混合体がセメントとして利用され、なかには、水および希薄リン酸水溶液で緩和するとアパタイトを形成しながら硬化するものがある。コラーゲン繊維上の骨様アパタイトを化学沈着して作製したアパタイト-コラーゲン複合体も上述の問題点を回避するもので、個々の微結晶はコラーゲン線維にかなりの強度で固着し、ピンセットもしくは指圧程度による変形では決して脱離しない。血液による湿潤も良好で、崩壊することもなく、骨欠損部にも容易に填入できるなどの利点を有し、骨補填材として有用である。本総説ではこれらリン酸カルシウム基材の合成法、物理化学的性状などの材料的な側面を解説し、臨床応用への可能性については主に著者らの結果に基づき解説することとした。","subitem_description_type":"Abstract"}]},"item_10002_description_81":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Calcium phosphates have been used safely and effectively as biomaterials during the past twenty years in dental and medical practice. For practical applications, microcrystals of calcium phosphates have been stuck together through many ways, since powdered forms of microcrystals have much less values in clinical practice and also appear to be phagocytosed by macrophages, which is a signal of a inflammatory response. In a way to stick calcium phosphate microcrsytals together, a high temperature fusion process called sintering has been employed. For sintering, calcium phosphates that are stable at higher temperatuers, at least at 1000℃ should be used, otherwise they produce by-products during sintering. Of calcium phosphates that are stable at 1100℃ stoichiometric hydroxyapatite, β-tricalcium phosphate and mixture of these two calcium phosphates have been used to produce particulate, denso and porous forms of biomaterials. In some applications, a few different calcium phosphates have been mixed to produce cements, which after mixing with water or diluted phosphoric acid set as the cement constituents convert to an apatitic phase, although with some cements the reaction product is not an apatitic phase. Apatite-collagen complex in which microcrystals of apatites were deposited on collagen fibers is another way to overcome the problem stated above. The adhesion of each crystal to collage fiber has been shown to be appreciably strong so that no apatite is visually observed to detach under deformation with fingers or a forceps. This type of apatite-collagen complex has been demonstrated to be useful as bone substitutes, since it is easily wetted with blood without any disintegration and can be implanted without difficulty in artificial bone defects. In the present review, materials properties of caldium phosphates are discussed, including their preparation methods and physicochemical properties. Some emphasis has been placed on the reviewer's work.","subitem_description_type":"Other"}]},"item_10002_full_name_75":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"3788","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Doi, Yutaka"}]}]},"item_10002_radio_89":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_radio_item":"application/pdf"}]},"item_10002_relation_85":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110000051255","subitem_relation_type_select":"NAID"}}]},"item_10002_relation_86":{"attribute_name":"医中誌文献番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2002238803","subitem_relation_type_select":"ICHUSHI"}}]},"item_10002_source_id_82":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03850072","subitem_source_identifier_type":"ISSN"}]},"item_10002_source_id_84":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053070","subitem_source_identifier_type":"NCID"}]},"item_10002_textarea_76":{"attribute_name":"所属","attribute_value_mlt":[{"subitem_textarea_value":"朝日大学歯学部歯科理工学講座"}]},"item_10002_textarea_78":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_textarea_value":"岐阜歯科学会"}]},"item_10002_version_type_95":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"33703","affiliationNameIdentifierScheme":"kakenhi","affiliationNameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=33703"}],"affiliationNames":[{"affiliationName":"朝日大学歯学部","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"土井, 豊","creatorNameLang":"ja"},{"creatorName":"DOI, YUTAKA","creatorNameLang":"en"}],"familyNames":[{"familyName":"土井","familyNameLang":"ja"},{"familyName":"DOI","familyNameLang":"en"}],"givenNames":[{"givenName":"豊","givenNameLang":"ja"},{"givenName":"YUTAKA","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"549","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000249264889","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000249264889"},{"nameIdentifier":"40116067","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40116067"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-12-04"}],"displaytype":"detail","filename":"gifushika283_281290_2002.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"gifushika283_281290_2002","url":"https://asahi-u.repo.nii.ac.jp/record/13702/files/gifushika283_281290_2002.pdf"},"version_id":"0c25bbb0-06b8-4938-b8c7-a6ef2a4713e0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Bioceramics","subitem_subject_scheme":"Other"},{"subitem_subject":"Bioactive cement","subitem_subject_scheme":"Other"},{"subitem_subject":"Apatite-collagen complex","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteoconduction","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteoinduction","subitem_subject_scheme":"Other"},{"subitem_subject":"Bioactive carrier","subitem_subject_scheme":"Other"},{"subitem_subject":"Apatites","subitem_subject_scheme":"Other"},{"subitem_subject":"Calcium Phosphates","subitem_subject_scheme":"Other"},{"subitem_subject":"セラミック","subitem_subject_scheme":"Other"},{"subitem_subject":"Collagen","subitem_subject_scheme":"Other"},{"subitem_subject":"医用材料","subitem_subject_scheme":"Other"},{"subitem_subject":"Bioceramics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Bioactive cement","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Apatite-collagen complex","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteoconduction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteoinduction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Bioactive carrier","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Apatites","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Calcium Phosphates","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Collagen","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"バイオセラミックス","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"バイオセラミックス"},{"subitem_title":"Bioceramics","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"21","path":["416"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-12-04"},"publish_date":"2021-12-04","publish_status":"0","recid":"13702","relation_version_is_last":true,"title":["バイオセラミックス"],"weko_creator_id":"21","weko_shared_id":-1},"updated":"2024-03-29T08:44:58.451442+00:00"}