{"created":"2023-06-23T12:21:58.337491+00:00","id":13741,"links":{},"metadata":{"_buckets":{"deposit":"2f7c75a5-624e-463f-bf75-254bca2a37d4"},"_deposit":{"created_by":21,"id":"13741","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"13741"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00013741","sets":["46:348:484"]},"author_link":["12924","15424","16646","3954","8884","16651","16653","16578","16650","2646","11230","16652","16647","16655","16570","2847","16572"],"item_10002_biblio_info_77":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"120","bibliographicPageStart":"115","bibliographicVolumeNumber":"48","bibliographic_titles":[{"bibliographic_title":"岐阜歯科学会雑誌"},{"bibliographic_title":"The Journal of Gifu Dental Society","bibliographic_titleLang":"en"}]}]},"item_10002_description_80":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ケオラオーラルモイスチャージェル（keora®）は、γ-グルタミルトランスペプチダーゼの阻害剤（ナールスゲン®）を配合した新規の口腔保湿ジェルである。本研究では、学生ボランティアを対象に、keora® による口腔内環境への効果を検討することを目的とした。朝日大学歯学部の学生ボランティア10名（男性 5名、女性5名）を対象とした。keora®の塗布を併用した口腔清掃を8週間行った。実験開始時（ベースライン）と8週間後に、口腔水分量、TCI（Tongue coating index）、および舌表面の細菌数を評価した。さらに、唾液検査システムを用いた測定も行った。ベースラインにおいて、全被験者の口腔水分量、TCI、および舌表面の細菌数の平均値（標準偏差）は、それぞれ27.5（0.8）、27.8（21.8）％、および5.9（5.5）log10 CFU/mlであった。一方、8週間後の全被験者の口腔水分量、TCI、および舌表面の細菌数の平均値（標準偏差）は、それぞれ29.0（0.8）、7.8（7.5）％、1.4（1.1）log10 CFU/mlとなった。いずれの指標についても、ベースラインと8週間後との間にそれぞれ有意差を認めた（p＜0.05）。また、唾液検査システムによる測定結果は、ベースラインと比べて8週間後の洗口吐出液中の齲蝕原性菌の値は有意に小さく（p＜0.05）、そして蛋白質の値が有意に大きくなることを示した（p＜0.05）。keora®の塗布を併用した口腔清掃を8週間行ったところ、学生ボランティアの口腔水分量と洗口吐出液中の蛋白質の値は増加した。また、TCI、舌表面の細菌数、および洗口吐出液中の齲蝕原性菌の値は減少することが分かった。","subitem_description_type":"Abstract"}]},"item_10002_description_81":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Keora Oral Moisture Gel (keora®) is a novel oral moisturizing gel containing Nahlsgen®. The purpose of this study was to investigate the effect of keora®  on the oral environment in student volunteers. Ten student volunteers (5 males and 5 females) from the School of Dentistry, Asahi University, Japan, were subjected to 8 weeks of oral cleaning combined with application of keora®. At the beginning of the experiment (baseline) and after 8 weeks, oral water content, TCI (tongue coating index), and the number of bacteria on the back of the tongue were evaluated. In addition, measurements were made using a saliva testing system. At baseline, the mean values (standard deviation) of oral water content, TCI, and bacterial count on the dorsal surface of the tongue for all subjects were 27.5 (0.8), 27.8 (21.8)%, and 5.9 (5.5) log10 CFU/ml, respectively. On the other hand, the mean (standard deviation) values of oral water content, TCI, and bacterial count on the dorsal surface of the tongue for all subjects after 8 weeks were 29.0 (0.8), 7.8 (7.5)%, and 1.4 (1.1) log10 CFU/ml, respectively. There was a significant difference in all indices between baseline and after 8 weeks (p<0.05). The results of the saliva testing system showed significantly smaller (p<0.05) and significantly larger (p<0.05) values of dental caries-producing bacteria and protein in the mouthwash discharge after 8 weeks compared to baseline. After 8 weeks of oral cleaning combined with keora® application, the oral water content and the protein in the mouthwash discharge of the student volunteers increased. TCI, the number of bacteria on the dorsal surface of the tongue, and dental caries-producing bacteria in the mouthwash solution were found to decrease.","subitem_description_type":"Other"}]},"item_10002_full_name_75":{"attribute_name":"著者別名","attribute_value_mlt":[{"affiliations":[{"affiliationNames":[{"affiliationName":"朝日大学歯学部","lang":"ja"}],"nameIdentifiers":[]}],"familyNames":[{"familyName":"米永","familyNameLang":"ja"},{"familyName":"YONENAGA","familyNameLang":"en"}],"givenNames":[{"givenName":"崇利","givenNameLang":"ja"},{"givenName":"TAKATOSHI","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16646","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000414940244","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000414940244"}],"names":[{"name":"米永, 崇利","nameLang":"ja"},{"name":"YONENAGA, TAKATOSHI","nameLang":"en"}]},{"nameIdentifiers":[{"nameIdentifier":"16578","nameIdentifierScheme":"WEKO"}],"names":[{"name":"AZUMA, 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Corporation"},{"subitem_textarea_value":"朝日大学歯学部口腔機能修復学講座歯科補綴学分野\nDepartment of Prosthodontics, Division of Oral Functional Science and Rehabilitation, School of Dentistry, Asahi University"},{"subitem_textarea_value":"朝日大学歯学部口腔感染医療学講座社会口腔保健学分野\nDepartment of Community Oral Health, Division of Oral Infections and Health Sciences, School of Dentistry, Asahi University"}]},"item_10002_version_type_95":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":"朝日大学歯学部","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"米永, 崇利","creatorNameLang":"ja"},{"creatorName":"YONENAGA, 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