{"created":"2023-06-23T12:22:00.838892+00:00","id":13800,"links":{},"metadata":{"_buckets":{"deposit":"6d4acd59-cce5-4454-b98c-3bc76a18f1b1"},"_deposit":{"created_by":21,"id":"13800","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"13800"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00013800","sets":["46:190:420"]},"author_link":["8701","3956","4915","4093","1290","4274","4668"],"item_10002_biblio_info_77":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-06-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"24","bibliographicPageStart":"1","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"岐阜歯科学会雑誌"},{"bibliographic_title":"The journal of Gifu Dental Society","bibliographic_titleLang":"en"}]}]},"item_10002_description_80":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"口腔発生に関連する口咽頭弓の発生過程を胎生10日から生後2日にわたってマウスを用いて観察し,口腔諸器官は,11日胚と12日胚で原基形成期,13日胚から17日胚で原基成長期,その後の臓器完成期を経て形成されることが判明した.これらの期間における胚細胞のホメオティック遺伝子産物と各種分化成長因子の発現様式を免疫組織化学的に観察した結果,体節の特徴付けに関連するホメオティック遺伝子産物は口咽頭弓においてもこの全期間を通じて発現され,細胞増殖性の指標となるPCNAは12日胚および17,18日胚に二相性のピークを示す発現性を示し,これと同様の発現性はNGFファミリー,EGFファミリーのリガンドとレセプターの同時発現に,またFGFファミリーの17,18日胚の発現にみられた.これに対して,TGF-βファミリーのリガンドとレセプターの同時発現は13〜15日胚に認められた.以上の所見は,発生に直接的に関連する胎仔細胞の増殖はNGF,EGFおよびFGFファミリーによって促進され,連にTGF-βスーパーファミリーによって抑制されること,およびTGF-βスーパーファミリーは細胞分化に関連していることが示唆された.","subitem_description_type":"Abstract"}]},"item_10002_description_81":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Light microscopic examination revealed that mouse oral organogenesis in the branchial arches is divided into three processes, the gene formation phase (11-12-day-old embryos), the germ growth phase (13-17-day-old embryos) and organ establishment phase (on and after day 18 of embriyonic development). Immunohistochemical study clarified that homeotic gene products which help give specificity of somite to certain cells in the embryo, Pax-9 and Hox-11 are expressed in almost cells in the branchial arches during all phases in this investigation PCNA indicating proliferation of cells was characterized by an expression pattern showing two peaks, one at 12 days and another at 17-18 of embryonic growth A simillar expression pattern to PCNA was observed in the simultaneous expression of the ligands and receptors of NGF and EGF families, and the same tendency of FGF family could be observed in the EGF family at 17-18-day-old In contrast, the expression peak of TGF-beta superfamily was limited to 13-15-day-old embryo. These results indicated that cell proliferation in the branchial arches is promoted by expression of the NGF, EGF and FGF families, and suppressed by TGF-beta superfamily. And it was suspected that TGF-beta superfamily influence cell differentiation to regulate organogenesis m the oral region.","subitem_description_type":"Other"}]},"item_10002_full_name_75":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"4915","nameIdentifierScheme":"WEKO"}],"names":[{"name":"MORIKAWA, RUMIKO"}]},{"nameIdentifiers":[{"nameIdentifier":"3956","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000261043356","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000261043356"}],"names":[{"name":"OHTOMO, KATSUYUKI"}]},{"affiliations":[{"affiliationNames":[{"affiliationName":"朝日大学歯学部","lang":"ja"}],"nameIdentifiers":[]}],"familyNames":[{"familyName":"永山","familyNameLang":"ja"},{"familyName":"NAGAYAMA","familyNameLang":"en"}],"givenNames":[{"givenName":"元彦","givenNameLang":"ja"},{"givenName":"MOTOHIKO","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1290","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000050298436","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000050298436"},{"nameIdentifier":"50298436","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50298436"}],"names":[{"name":"永山, 元彦","nameLang":"ja"},{"name":"NAGAYAMA, MOTOHIKO","nameLang":"en"}]},{"nameIdentifiers":[{"nameIdentifier":"4274","nameIdentifierScheme":"WEKO"}],"names":[{"name":"TAKEUCHI, HIROSHI"}]}]},"item_10002_heading_98":{"attribute_name":"見出し","attribute_value_mlt":[{"subitem_heading_banner_headline":"原著","subitem_heading_language":"ja"},{"subitem_heading_banner_headline":"ORIGINAL ARTICLES","subitem_heading_language":"en"}]},"item_10002_radio_89":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_radio_item":"application/pdf"}]},"item_10002_relation_85":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"80016242500","subitem_relation_type_select":"NAID"}}]},"item_10002_source_id_82":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03850072","subitem_source_identifier_type":"ISSN"}]},"item_10002_source_id_84":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053070","subitem_source_identifier_type":"NCID"}]},"item_10002_textarea_76":{"attribute_name":"所属","attribute_value_mlt":[{"subitem_textarea_value":"朝日大学歯学部口腔病理学講座\nDepartment of Oral Pathology, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部外科学講座\nDepartment of Surgery, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部口腔病理学講座\nDepartment of Oral Pathology, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部口腔病理学講座\nDepartment of Oral Pathology, Asahi University School of Dentistry"}]},"item_10002_version_type_95":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"森川, 留美子"}],"nameIdentifiers":[{"nameIdentifier":"4668","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002270003","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002270003"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"大友, 克之","creatorNameLang":"ja"},{"creatorName":"OTOMO, KATSUYUKI","creatorNameLang":"en"}],"familyNames":[{"familyName":"大友","familyNameLang":"ja"},{"familyName":"OTOMO","familyNameLang":"en"}],"givenNames":[{"givenName":"克之","givenNameLang":"ja"},{"givenName":"KATSUYUKI","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8701","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002270022","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002270022"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":"朝日大学歯学部","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"永山, 元彦","creatorNameLang":"ja"},{"creatorName":"NAGAYAMA, 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HIROSHI","creatorNameLang":"en"}],"familyNames":[{"familyName":"竹内","familyNameLang":"ja"},{"familyName":"TAKEUCHI","familyNameLang":"en"}],"givenNames":[{"givenName":"宏","givenNameLang":"ja"},{"givenName":"HIROSHI","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4093","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000040102123","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000040102123"},{"nameIdentifier":"40102123","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40102123"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-12"}],"displaytype":"detail","filename":"gifushika301_124_2003.pdf","filesize":[{"value":"5.9 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"gifushika301_124_2003","url":"https://asahi-u.repo.nii.ac.jp/record/13800/files/gifushika301_124_2003.pdf"},"version_id":"2d154b11-de54-4af7-bf89-74699b72cd63"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"口腔発生","subitem_subject_scheme":"Other"},{"subitem_subject":"鰓弓","subitem_subject_scheme":"Other"},{"subitem_subject":"ホメオティック遺伝子産物","subitem_subject_scheme":"Other"},{"subitem_subject":"分化・成長因子","subitem_subject_scheme":"Other"},{"subitem_subject":"Oral organogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Branchial arches","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Homeotic gene product","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Differentmtmg-growth factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"マウス口腔領域の発生におけるホメオティック遺伝子産物と分化・成長因子の発現様式","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マウス口腔領域の発生におけるホメオティック遺伝子産物と分化・成長因子の発現様式"},{"subitem_title":"Expression Pattern of Homeotic-and Growth-associated Gene Products on the Organogenesis of Mouse Oral Region","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"21","path":["420"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-03-12"},"publish_date":"2022-03-12","publish_status":"0","recid":"13800","relation_version_is_last":true,"title":["マウス口腔領域の発生におけるホメオティック遺伝子産物と分化・成長因子の発現様式"],"weko_creator_id":"21","weko_shared_id":-1},"updated":"2024-01-17T07:09:13.925410+00:00"}