{"created":"2023-06-23T12:22:00.881655+00:00","id":13801,"links":{},"metadata":{"_buckets":{"deposit":"eb1bde45-f8ae-4154-9078-df86f244f361"},"_deposit":{"created_by":21,"id":"13801","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"13801"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00013801","sets":["46:190:420"]},"author_link":["4925","4353","4356","4923","4351","4101","4347","16678"],"item_10002_biblio_info_77":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-06-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"36","bibliographicPageStart":"25","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"岐阜歯科学会雑誌"},{"bibliographic_title":"The journal of Gifu Dental Society","bibliographic_titleLang":"en"}]}]},"item_10002_description_80":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"歯肉増殖はカルシウム拮抗薬による副作用である.本研究の目的は,ニフェジピンによる増殖歯肉の細胞外マトリックスの主成分であるグリコサミノグリカンとコラーゲン性蛋白の代謝を検討することである.生後20日齢のSpecific pathogen freeのラットを無作為に3群に分けた.実験群は40日間と80日間,ニフェジピン含有の飼料を与えた.歯肉より抽出されたグリコサミノグリカンは定性・定量分析のため,セルロースアセテート膜電気泳動によって分離した.グリコサミノグリカンとコラーゲン性蛋白の代謝実験には^3H-グルコサミン,^3H-プロリンを各々指標として用いた.実験群におけるグリコサミノグリカン量はニフェジピン投与依存性に対照群より増量した.コラーゲン性蛋白への^3H-プロリンの取り込みは対照群と比較して,実験群において高い傾向を示した.一方,グリコサミノグリカンヘの^3H-グルコサミンの取り込みについてはニフェジピンの影響は認められなかった.以上の結果より,ニフェジピン投与ラットにおける歯肉のグリコサミノグリカンの増量は,グリコサミノグリカンの分解の抑制による可能性が示唆された.","subitem_description_type":"Abstract"}]},"item_10002_description_81":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Gingival overgrowth is a common side effect associated with calcium channel blockers The objective of this study was to examine the metabolism of glycosammoglycan and collagenous protein, which are major components of extra-cellular matrix in gmgival overgrowth by nifedipine. Specific pathogen-free, 20-day-old male rats were randomly divided into 3 groups Animals in experimental groups were fed a diet containing nifedipine for 40 and 80 days. Glycosaminoglycans were extracted from gingiva and separated by cellulose acetate membrane electro-phoresis for both qualitative and quantitative analysis maru ^3H-glucosamine and ^3H-prohne were used for metabolic study of glycosaminoglycan and collagenous protein, respectively. The glycosaminoglycan levels in nifedipine groups were higher than that of control in a dose-dependent manner. The incorporation of ^3H-proline into collagenous protein was increased in the experimental groups compared to the control group, however, nifedipine showed effect on ^3H-glucosamine incorporation into glycosamin oglycan. These results suggest that the high level of gingival glycosaminoglycan in nifedipine rats may has been due to the suppresion of glycosaminoglycan degradation.","subitem_description_type":"Other"}]},"item_10002_full_name_75":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"4923","nameIdentifierScheme":"WEKO"}],"names":[{"name":"NAKAJYO, YOUKO"}]},{"nameIdentifiers":[{"nameIdentifier":"4351","nameIdentifierScheme":"WEKO"}],"names":[{"name":"KATO, MAKIKO"}]},{"nameIdentifiers":[{"nameIdentifier":"4925","nameIdentifierScheme":"WEKO"}],"names":[{"name":"SHIRAKI, MASAFUMI"}]},{"nameIdentifiers":[{"nameIdentifier":"4353","nameIdentifierScheme":"WEKO"}],"names":[{"name":"IWAYAMA, YUKIO"}]}]},"item_10002_heading_98":{"attribute_name":"見出し","attribute_value_mlt":[{"subitem_heading_banner_headline":"原著","subitem_heading_language":"ja"},{"subitem_heading_banner_headline":"ORIGINAL ARTICLES","subitem_heading_language":"en"}]},"item_10002_radio_89":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_radio_item":"application/pdf"}]},"item_10002_relation_85":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110000051311","subitem_relation_type_select":"NAID"}}]},"item_10002_source_id_82":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03850072","subitem_source_identifier_type":"ISSN"}]},"item_10002_source_id_84":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053070","subitem_source_identifier_type":"NCID"}]},"item_10002_textarea_76":{"attribute_name":"所属","attribute_value_mlt":[{"subitem_textarea_value":"朝日大学歯学部歯周病学講座\nDepartment of Periodontology. Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部歯周病学講座\nDepartment of Periodontology. Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部歯周病学講座\nDepartment of Periodontology. Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部歯周病学講座\nDepartment of Periodontology. Asahi University School of Dentistry"}]},"item_10002_version_type_95":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中條, 葉子"}],"nameIdentifiers":[{"nameIdentifier":"4356","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002144180","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002144180"}]},{"creatorNames":[{"creatorName":"加藤, 牧子"}],"nameIdentifiers":[{"nameIdentifier":"4347","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002269855","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002269855"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":"朝日大学","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"白木, 雅文","creatorNameLang":"ja"},{"creatorName":"SHIRAKI, MASAFUMI","creatorNameLang":"en"}],"familyNames":[{"familyName":"白木","familyNameLang":"ja"},{"familyName":"SHIRAKI","familyNameLang":"en"}],"givenNames":[{"givenName":"雅文","givenNameLang":"ja"},{"givenName":"MASAFUMI","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4101","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000070121324","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000070121324"},{"nameIdentifier":"70121324","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70121324"}]},{"creatorNames":[{"creatorName":"岩山, 幸雄"}],"nameIdentifiers":[{"nameIdentifier":"16678","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-12"}],"displaytype":"detail","filename":"gifushika301_2536_2003.pdf","filesize":[{"value":"4.1 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"gifushika301_2536_2003","url":"https://asahi-u.repo.nii.ac.jp/record/13801/files/gifushika301_2536_2003.pdf"},"version_id":"7d3998fc-dc57-40ea-8cc8-9445f65aa0c2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ニフェジピン","subitem_subject_scheme":"Other"},{"subitem_subject":"歯肉増殖","subitem_subject_scheme":"Other"},{"subitem_subject":"グリコサミノグリカン","subitem_subject_scheme":"Other"},{"subitem_subject":"Nifedipine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Gingival overgrowth","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Glycosaminoglycan","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ニフェジピン投与ラットの歯肉増殖への細胞外マトリックスの関与","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ニフェジピン投与ラットの歯肉増殖への細胞外マトリックスの関与"},{"subitem_title":"Effect of Extra-cellular Matrix on Gingival Overgrowth Induced by Nifedipine in Rat","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"21","path":["420"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-03-12"},"publish_date":"2022-03-12","publish_status":"0","recid":"13801","relation_version_is_last":true,"title":["ニフェジピン投与ラットの歯肉増殖への細胞外マトリックスの関与"],"weko_creator_id":"21","weko_shared_id":-1},"updated":"2024-01-06T02:06:21.053939+00:00"}