{"created":"2023-06-23T12:22:06.175369+00:00","id":13901,"links":{},"metadata":{"_buckets":{"deposit":"63b0b1b3-6fcd-4016-9439-9aad2a3dc82f"},"_deposit":{"created_by":21,"id":"13901","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"13901"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00013901","sets":["46:190:421"]},"author_link":["4656","4048"],"item_10002_biblio_info_77":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-10-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"125","bibliographicPageStart":"113","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"岐阜歯科学会雑誌"},{"bibliographic_title":"The Journal of Gifu Dental Society","bibliographic_titleLang":"en"}]}]},"item_10002_description_80":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"顎関節円板はフィブリルコラーゲンとグリコサミノグリカンを主体とする線維性組織で、機能負荷に対応する緩衝装置の役割を果たしている。顎関節円板に加わる負荷は年齢や咬合状態などによって大きなバリエーションを生ずる。本研究では、成長期における関節円板のフィブリルコラーゲンの量的および質的変化を観察するとともに、拳上あるいは抜歯により咬合状態の変化がそれらにおよぼす影響についての基礎的資料を収集した。ラット顎関節円板から不溶性コラーゲンを抽出したヒドロキシプロリン量を指標とした化学分析を行い、さらに、コラーゲン分子間架橋結合を酵素限定消化法で切断しコラーゲンの可溶化をはかった。可溶化コラーゲンは熱変性させたのち、途中還元電気泳動法を応用して分子内架橋結合の切断とα鎖の分離を行い、ウェスタンブロッティング法で解析した。ラット顎関節円板のフィブリルコラーゲン量は4週齢で増加し、その後は一定値を維持した。分子種はI型コラーゲンを主体として、II型、III型コラーゲンが分布し、その構成比率はI型コラーゲンではほぼ一定であるが、加齢と咬合関係の不調和はII型、III型コラーゲンに影響を及ぼすことが示唆された。","subitem_description_type":"Abstract"}]},"item_10002_description_81":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"This paper reports the biochemical investigation in fibril collagen in the articular disc of the rat temporomandibular joint with experimental occlusal disharmony. The articular discs were removed from rats at 3, 4, 6 and 10 weeks after birth. Fibril collagen was extracted from the discs and solubilized by pepsin digestion. Pepsin-soluble collagen molecules were fractionated by interrupted gel electrophoresis in a denatured state and analyzed immunochemically by Western blotting. The content of fibril collagen increased with age, especially in the 4-week extracts. The fibril coolagen in discs consisted mainly of type I, and small amounts of type Ⅱ and Ⅲ. No remarkable changes were observed on the distribution amount for type Ⅰ collagen with age. Quantitative changes of type Ⅱ and Ⅲ collagen with age and occlusal disharmony may be related to the functional role of the articular disc. \n ","subitem_description_type":"Other"}]},"item_10002_full_name_75":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"4656","nameIdentifierScheme":"WEKO"}],"names":[{"name":"TANAHASHI, TOMOYA"}]}]},"item_10002_heading_98":{"attribute_name":"見出し","attribute_value_mlt":[{"subitem_heading_banner_headline":"原著","subitem_heading_language":"ja"},{"subitem_heading_banner_headline":"ORIGINAL ARTICLES","subitem_heading_language":"en"}]},"item_10002_radio_89":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_radio_item":"application/pdf"}]},"item_10002_relation_85":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110004689605","subitem_relation_type_select":"NAID"}}]},"item_10002_relation_86":{"attribute_name":"医中誌文献番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2004180153","subitem_relation_type_select":"ICHUSHI"}}]},"item_10002_source_id_82":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-0072","subitem_source_identifier_type":"ISSN"}]},"item_10002_source_id_84":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053070","subitem_source_identifier_type":"NCID"}]},"item_10002_textarea_76":{"attribute_name":"所属","attribute_value_mlt":[{"subitem_textarea_value":"朝日大学大学院歯学研究科口腔生化学専攻\nDepartment of Oral Biochemistry, Division of Oral Structure, Function and Development, Asahi University Graduate School of Dentistry"}]},"item_10002_version_type_95":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"棚橋, 友哉"}],"nameIdentifiers":[{"nameIdentifier":"4048","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002269996","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002269996"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-17"}],"displaytype":"detail","filename":"gifushika302_113125_2003.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"gifushika302_113125_2003","url":"https://asahi-u.repo.nii.ac.jp/record/13901/files/gifushika302_113125_2003.pdf"},"version_id":"019aa864-cae1-477c-acc9-6fca9521f8f9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"コラーゲン","subitem_subject_scheme":"Other"},{"subitem_subject":"関節円板","subitem_subject_scheme":"Other"},{"subitem_subject":"加齢","subitem_subject_scheme":"Other"},{"subitem_subject":"咬合","subitem_subject_scheme":"Other"},{"subitem_subject":"抜歯","subitem_subject_scheme":"Other"},{"subitem_subject":"顎関節円板","subitem_subject_scheme":"Other"},{"subitem_subject":"咬合調整","subitem_subject_scheme":"Other"},{"subitem_subject":"Sprague-Dawleyラット","subitem_subject_scheme":"Other"},{"subitem_subject":"咬合挙上","subitem_subject_scheme":"Other"},{"subitem_subject":"Collagen","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Articular disc","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sprague-Dawley rat","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ラット顎関節円板のフィブリルコラーゲンの加齢変化と咬合状態の影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ラット顎関節円板のフィブリルコラーゲンの加齢変化と咬合状態の影響"},{"subitem_title":"The Effect of Growth and Occlusal Disharmony on Fibril Collagen in the Articular Disc of the Rat Temporomandibular Joint","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"21","path":["421"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-05-17"},"publish_date":"2022-05-17","publish_status":"0","recid":"13901","relation_version_is_last":true,"title":["ラット顎関節円板のフィブリルコラーゲンの加齢変化と咬合状態の影響"],"weko_creator_id":"21","weko_shared_id":-1},"updated":"2023-06-23T12:43:05.106278+00:00"}