@article{oai:asahi-u.repo.nii.ac.jp:00013981,
 author = {福岡, 幸伸 and 永山, 元彦 and NAGAYAMA, MOTOHIKO and 土井, 豊 and DOI, YUTAKA},
 issue = {2004-11-20},
 journal = {2004-11-20},
 month = {2004-11-20, 2022-11-08},
 note = {Histological and immunohistochemical findings are presented from two patients using composite biomaterial graft in combination with autogenous cancellous bone, platelet-rich plasma (PRP) and β-tricalcium phosphate (β-TCP). A composite biomaterial graft was constructed and implants were installed using a staged approach into a 59-year-old man with a large alveolar bone defect in the right mandibular first molar (Patient 1) and a 51-year-old woman with an upper left horizontal impacted canine (Patient 2). Six months later, core biopsies of the grafted areas from both patients were histologically and immunohistochemically stained for osteocalcin, platelet-derived growth factor (PDGF), transforming growth factor beta 1 (TGF-β1) and CD68. Wound healing and the handling of graft material are improved by PRP. The histological evidence demonstrated that new bone was generated in both patients. Neither inflammatory cells nor necrosis were evident in the graft areas. Osteoid with osteoblasts and osseous granulation tissue were mainly evident in Patient 1, but mature lamina bone had generated in Patient 2, suggesting that bone regeneration depends on the type of defect and condition of the blood supply. Immunohistochemically, osteocalcin and TGF-β1 were localized in the cells (osteoblasts) around osteoid and PDGF was detected in the osseous granulation tissues of Patient 1. To some extent, resolved β-TCP particles were surrounded by CD68 positive macrophages.},
 pages = {2004-11-20--2004-11-20},
 title = {自家骨, PRPおよβ-TCPからなる骨補填材による骨再生},
 volume = {2004-11-20},
 year = {}
}