{"created":"2023-06-23T12:22:10.578888+00:00","id":13981,"links":{},"metadata":{"_buckets":{"deposit":"14addb69-061d-4a1f-80eb-9151fa74db39"},"_deposit":{"created_by":21,"id":"13981","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"13981"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00013981","sets":["46:190:423"]},"author_link":["4457","3788","4467","1290","549"],"item_10002_biblio_info_77":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-11-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"特集","bibliographicPageEnd":"44","bibliographicPageStart":"37","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"岐阜歯科学会雑誌"},{"bibliographic_title":"The Journal of Gifu Dental Society","bibliographic_titleLang":"en"}]}]},"item_10002_description_80":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Histological and immunohistochemical findings are presented from two patients using composite biomaterial graft in combination with autogenous cancellous bone, platelet-rich plasma (PRP) and β-tricalcium phosphate (β-TCP). A composite biomaterial graft was constructed and implants were installed using a staged approach into a 59-year-old man with a large alveolar bone defect in the right mandibular first molar (Patient 1) and a 51-year-old woman with an upper left horizontal impacted canine (Patient 2). Six months later, core biopsies of the grafted areas from both patients were histologically and immunohistochemically stained for osteocalcin, platelet-derived growth factor (PDGF), transforming growth factor beta 1 (TGF-β1) and CD68. Wound healing and the handling of graft material are improved by PRP. The histological evidence demonstrated that new bone was generated in both patients. Neither inflammatory cells nor necrosis were evident in the graft areas. Osteoid with osteoblasts and osseous granulation tissue were mainly evident in Patient 1, but mature lamina bone had generated in Patient 2, suggesting that bone regeneration depends on the type of defect and condition of the blood supply. Immunohistochemically, osteocalcin and TGF-β1 were localized in the cells (osteoblasts) around osteoid and PDGF was detected in the osseous granulation tissues of Patient 1. To some extent, resolved β-TCP particles were surrounded by CD68 positive macrophages.","subitem_description_type":"Abstract"}]},"item_10002_description_81":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"β-リン酸三カルシウム(β-TCP),自家骨ならびに多血小板血漿(PRP)からなる混合生体骨補填材をヒト2人に埋入し,その有用性を組織的ならびに免疫組織化学的に評価した.被験者一人は59歳の男性で下顎右側第一大臼歯部に歯冠大の辺縁性歯根膜炎による骨吸収が認められ,もう一人の被験者は51歳の女性で左側上顎埋伏犬歯を有していた.6ヵ月後,両被験者より採取した組織を組織学的ならびにオステオカルシン,血小板由来成長因子(PDGF),形質転換促進因子β1(TGF-β1)およびCD68について免疫組織化学的染色を行った.PRPにより創傷治癒ならびに補填材の操作性の向上が認められた.組織学的に両被験者共に新生骨の再生が認められ,骨補填部位では炎症性細胞ならびに壊死組織は認められなかった.被験者1では主として骨芽細胞と骨性肉芽組織を含む類骨が認められたが,被験者2では成熟した層板骨が認められ,骨の再生は欠損形態と血液供給の状態に依存することが示唆された.免疫組織化学的な所見では被験者1においてオステオカルシンならびにTGF-βが類骨周辺の細胞(骨芽細胞)に局在していることが認められた.PDGFは骨性肉芽組織に認められ,吸収されたβ-TCP小顆粒の周辺にはCD68陽性のマクロファージの存在が確認できた.","subitem_description_type":"Other"}]},"item_10002_full_name_75":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"4467","nameIdentifierScheme":"WEKO"}],"names":[{"name":"FUKUOKA, YUKINOBU"}]},{"affiliations":[{"affiliationNames":[{"affiliationName":"朝日大学歯学部","lang":"ja"}],"nameIdentifiers":[]}],"familyNames":[{"familyName":"永山","familyNameLang":"ja"},{"familyName":"NAGAYAMA","familyNameLang":"en"}],"givenNames":[{"givenName":"元彦","givenNameLang":"ja"},{"givenName":"MOTOHIKO","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1290","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000050298436","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000050298436"},{"nameIdentifier":"50298436","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50298436"}],"names":[{"name":"永山, 元彦","nameLang":"ja"},{"name":"NAGAYAMA, MOTOHIKO","nameLang":"en"}]},{"nameIdentifiers":[{"nameIdentifier":"3788","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Doi, Yutaka"}]}]},"item_10002_heading_98":{"attribute_name":"見出し","attribute_value_mlt":[{"subitem_heading_banner_headline":"Implantology Research","subitem_heading_headline":"Regeneration with Autogenous PRP, Bone and β-TCP","subitem_heading_language":"en"}]},"item_10002_radio_89":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_radio_item":"application/pdf"}]},"item_10002_relation_86":{"attribute_name":"医中誌文献番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2005118864","subitem_relation_type_select":"ICHUSHI"}}]},"item_10002_source_id_82":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-0072","subitem_source_identifier_type":"ISSN"}]},"item_10002_source_id_84":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053070","subitem_source_identifier_type":"NCID"}]},"item_10002_textarea_76":{"attribute_name":"所属","attribute_value_mlt":[{"subitem_textarea_value":"Department of Dental Materials Science, Division of Oral Functional Science and Rehabilitation, Asahi University School of Dentistry\n朝日大学歯学部口腔機能修復学講座歯科理工学分野"},{"subitem_textarea_value":"Department of Oral Pathology, Division of Oral Pathogenesis and Disease Control, Asahi University School of Dentistry\n朝日大学歯学部口腔病態医療学講座口腔病理学分野"},{"subitem_textarea_value":"Department of Dental Materials Science, Division of Oral Functional Science and Rehabilitation, Asahi University School of Dentistry\n朝日大学歯学部口腔機能修復学講座歯科理工学分野\n"}]},"item_10002_version_type_95":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"福岡, 幸伸"}],"nameIdentifiers":[{"nameIdentifier":"4457","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002269912","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002269912"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":"朝日大学歯学部","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"永山, 元彦","creatorNameLang":"ja"},{"creatorName":"NAGAYAMA, MOTOHIKO","creatorNameLang":"en"}],"familyNames":[{"familyName":"永山","familyNameLang":"ja"},{"familyName":"NAGAYAMA","familyNameLang":"en"}],"givenNames":[{"givenName":"元彦","givenNameLang":"ja"},{"givenName":"MOTOHIKO","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1290","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000050298436","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000050298436"},{"nameIdentifier":"50298436","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50298436"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"33703","affiliationNameIdentifierScheme":"kakenhi","affiliationNameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=33703"}],"affiliationNames":[{"affiliationName":"朝日大学歯学部","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"土井, 豊","creatorNameLang":"ja"},{"creatorName":"DOI, YUTAKA","creatorNameLang":"en"}],"familyNames":[{"familyName":"土井","familyNameLang":"ja"},{"familyName":"DOI","familyNameLang":"en"}],"givenNames":[{"givenName":"豊","givenNameLang":"ja"},{"givenName":"YUTAKA","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"549","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000249264889","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000249264889"},{"nameIdentifier":"40116067","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40116067"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-08"}],"displaytype":"detail","filename":"gifushika30S_3744_2004.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"gifushika30S_3744_2004","url":"https://asahi-u.repo.nii.ac.jp/record/13981/files/gifushika30S_3744_2004.pdf"},"version_id":"46bbe58c-031b-4122-b8a5-513ab45d5843"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"PRP","subitem_subject_scheme":"Other"},{"subitem_subject":"β-TCP","subitem_subject_scheme":"Other"},{"subitem_subject":"PDGF","subitem_subject_scheme":"Other"},{"subitem_subject":"TGF-β1","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteocalcin","subitem_subject_scheme":"Other"},{"subitem_subject":"CD68","subitem_subject_scheme":"Other"},{"subitem_subject":"PRP","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"β-TCP","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"PDGF","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"TGF-β1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteocalcin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CD68","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"自家骨, PRPおよβ-TCPからなる骨補填材による骨再生","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"自家骨, PRPおよβ-TCPからなる骨補填材による骨再生"},{"subitem_title":"Regeneration with Biomaterial Bone Substitute Combined with Autogenous PRP, Bone and β-TCP","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"21","path":["423"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-11-08"},"publish_date":"2022-11-08","publish_status":"0","recid":"13981","relation_version_is_last":true,"title":["自家骨, PRPおよβ-TCPからなる骨補填材による骨再生"],"weko_creator_id":"21","weko_shared_id":-1},"updated":"2024-03-29T08:45:01.231171+00:00"}