{"created":"2023-06-23T12:22:10.707211+00:00","id":13984,"links":{},"metadata":{"_buckets":{"deposit":"c8ad0a0a-03f3-4a07-9821-de59076d4a83"},"_deposit":{"created_by":21,"id":"13984","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"13984"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00013984","sets":["46:190:423"]},"author_link":["1764","5367","5469","16775","8604","16776","1770","5465"],"item_10002_biblio_info_77":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-11-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"特集","bibliographicPageEnd":"60","bibliographicPageStart":"54","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"岐阜歯科学会雑誌"},{"bibliographic_title":"The journal of Gifu Dental Society","bibliographic_titleLang":"en"}]}]},"item_10002_description_80":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"There are regional differences in vascular hyporesponsiveness during sepsis. To determine whether nitric oxide (NO) was responsible for these regional differences, we investigated L-arginine (a substrate of NO synthase)-induced relaxation, which reflects the functional activity of NO synthase, in rat vessels treated with lipopolysaccharide (LPS). For in vivo LPS treatment, LPS (20mg/kg) was administered intraperitoneally. The following vessels were isolated after six hours : the carotid, pulmonary, mesenteric, renal, and femoral arteries, and the mesenteric and femoral veins. For in vitro LPS treatment, vessels isolated from LPS-untreated rats were incubated with LPS (1μg/ml) for six hours in an organ chamber. The vascular relaxant responses to L-arginine or sodium nitroprusside (SNP ; an NO-releasing drug) were measured by functional examination. All of the vessels from LPS-treated rats responded well to L-arginine, resulting in different relaxant amplitudes among the vessels (P<0.05). The relaxant amplitudes by L-arginine were not correlated with those by SNP (R=0.08, P>0.05). In the vessels treated with LPS in vitro, on the other hand, the different relaxant amplitudes by L-arginine (P<0.05) were significant linearly correlated with those by SNP (R=0.70, P<0.05). These results suggested that the different relaxant amplitudes by L-arginine among the vessels isolated from LPS-treated rats were caused not only by different responses to NO, but also by different activity of inducible NO synthase among the vessels. During sepsis, the regional heterogeneity of the activation of inducible NO synthase may contribute to heterogeneous redistribution of blood flow.","subitem_description_type":"Abstract"}]},"item_10002_description_81":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"細菌内毒素(LPS)処置胸部大動脈,大腿動静脈,腸管膜動静脈,頚動脈,肺動脈及び腎動脈を用い,L-arginine(NO合成酵素基質)とnitroprusside (SNP, NO遊離薬)の血管弛緩反応性を比較検討した.LPS処置した全ての血管はL-アルギニン及びSNPにより弛緩反応を惹起したが,その程度は血管部位だけでなく薬剤によっても異なった.この結果からL-アルギニンによる血管弛緩反応の血管の部位差がNOに対する反応性の差だけではなく細菌内毒素により誘導されるNO合成酵素活性の差にも関係していることが示唆された.","subitem_description_type":"Other"}]},"item_10002_full_name_75":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"5367","nameIdentifierScheme":"WEKO"}],"names":[{"name":"TAKAKURA, KO"}]},{"nameIdentifiers":[{"nameIdentifier":"5469","nameIdentifierScheme":"WEKO"}],"names":[{"name":"OOSHIMA, KAZUYUKI"}]},{"nameIdentifiers":[{"nameIdentifier":"16776","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ONO, YASUSHI"}]},{"nameIdentifiers":[{"nameIdentifier":"1764","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000010231614","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000010231614"}],"names":[{"name":"Mizogami, Maki"}]}]},"item_10002_heading_98":{"attribute_name":"見出し","attribute_value_mlt":[{"subitem_heading_banner_headline":"No in Sepsis","subitem_heading_headline":"Heterogeneity of relaxation in LPS-treated Vessels","subitem_heading_language":"en"}]},"item_10002_radio_89":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_radio_item":"application/pdf"}]},"item_10002_relation_85":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110004689630","subitem_relation_type_select":"NAID"}}]},"item_10002_relation_86":{"attribute_name":"医中誌文献番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2005118866","subitem_relation_type_select":"ICHUSHI"}}]},"item_10002_source_id_82":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-0072","subitem_source_identifier_type":"ISSN"}]},"item_10002_source_id_84":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053070","subitem_source_identifier_type":"NCID"}]},"item_10002_textarea_76":{"attribute_name":"所属","attribute_value_mlt":[{"subitem_textarea_value":"Department of Anesthesiology, Division of General Medicine Asahi University School of Dentistry\n朝日大学歯学部総合医科学講座麻酔学分野"},{"subitem_textarea_value":"Department of Anesthesiology, Division of General Medicine Asahi University School of Dentistry\n朝日大学歯学部総合医科学講座麻酔学分野"},{"subitem_textarea_value":"Department of Anesthesiology, Division of General Medicine Asahi University School of Dentistry\n朝日大学歯学部総合医科学講座麻酔学分野"},{"subitem_textarea_value":"Department of Anesthesiology, Division of General Medicine Asahi University School of Dentistry\n朝日大学歯学部総合医科学講座麻酔学分野"}]},"item_10002_version_type_95":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高倉, 康"}],"nameIdentifiers":[{"nameIdentifier":"8604","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000006090746","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000006090746"},{"nameIdentifier":"40206735","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40206735"}]},{"creatorNames":[{"creatorName":"大嶋, 和之"}],"nameIdentifiers":[{"nameIdentifier":"5465","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000006090748","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000006090748"}]},{"creatorNames":[{"creatorName":"小野, 靖志"}],"nameIdentifiers":[{"nameIdentifier":"16775","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000006090750","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000006090750"}]},{"creatorNames":[{"creatorName":"溝上, 真樹"}],"nameIdentifiers":[{"nameIdentifier":"1770","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000010231614","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000010231614"},{"nameIdentifier":"10231614","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10231614"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-09"}],"displaytype":"detail","filename":"gifushika30S_5460_2004.pdf","filesize":[{"value":"612.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"gifushika30S_4553_2004","url":"https://asahi-u.repo.nii.ac.jp/record/13984/files/gifushika30S_5460_2004.pdf"},"version_id":"da94a1d9-3ba3-4d45-8b33-877acf861edf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"L-arginine","subitem_subject_scheme":"Other"},{"subitem_subject":"Nitroprusside","subitem_subject_scheme":"Other"},{"subitem_subject":"一酸化窒素(NO)","subitem_subject_scheme":"Other"},{"subitem_subject":"敗血症","subitem_subject_scheme":"Other"},{"subitem_subject":"細菌内毒素","subitem_subject_scheme":"Other"},{"subitem_subject":"L-arginine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sodium nitroprusside","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nitric oxide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sepsis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lipopolysaccharide","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"LPS処置血管平滑筋における L-arginine と Nitroprusside による弛緩反応の比較","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"LPS処置血管平滑筋における L-arginine と Nitroprusside による弛緩反応の比較"},{"subitem_title":"Comparison of L-arginine with Sodium Nitroprusside on Relaxant Responses in Lipopolysaccharide-treated Rat Blood Vessels","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"21","path":["423"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-11-09"},"publish_date":"2022-11-09","publish_status":"0","recid":"13984","relation_version_is_last":true,"title":["LPS処置血管平滑筋における L-arginine と Nitroprusside による弛緩反応の比較"],"weko_creator_id":"21","weko_shared_id":-1},"updated":"2023-06-23T12:41:30.114281+00:00"}