{"created":"2023-06-23T12:22:11.949468+00:00","id":14013,"links":{},"metadata":{"_buckets":{"deposit":"30a06077-e16d-4c51-bb88-62db2f170471"},"_deposit":{"created_by":21,"id":"14013","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"14013"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00014013","sets":["46:190:423"]},"author_link":["5680","8782","16829","5543","16834","16831","16832","16830","5673","5377","5539","16833","3836"],"item_10002_biblio_info_77":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-11-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"特集","bibliographicPageEnd":"289","bibliographicPageStart":"277","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"岐阜歯科学会雑誌"},{"bibliographic_title":"The journal of Gifu Dental Society","bibliographic_titleLang":"en"}]}]},"item_10002_description_80":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ヒトをはじめ動物は食物中にしばしば含まれる毒物に対し,それを無害化する手段を進化の過程で獲得してきた.例えば,食物中のタンニンは動物に対しさまざまな有害作用をもたらすが,クマやヘラジカのようにタンニンを含む植物を常食とする動物は唾液の中にその毒性を低下させる高プロリン・タンパク(PRP)を持つようになった.また,ラットやマウスは本来このタンパクを持たないが,タンニンを含む飼料を数日間食べると唾液中にPRPが誘導され生存することができる.一方,このタンパクを誘導できないハムスターはやせ衰え死んでしまう.パパイン(システインプロテアーゼ)やカプサイシン(唐辛子の辛味成分)により誘導されるシスタチンも同じ範疇に属するペプチドと思われるが,PRPに比べ未だ情報量は少ない.本稿では,食物中の毒物・侵害物質の処理に関係すると思われる唾液タンパクについて解説する.","subitem_description_type":"Abstract"}]},"item_10002_description_81":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Animals have evolved tools for coping with the toxic substances often contained in food. Proline-rich protein, found in saliva only, is a well-known example of such tools. This protein binds to the tannins that occur widely in plant foodstuff, preventing them from being absorbed from the gut, and attenuating their toxic effects (digestive trouble, carcinogenesis, liver disease and so on). Of the species without this salivary protein, rats and mice can produce it by ingesting tannin diets for a few days, but hamsters can not. When fed such diets, rats and mice live normally whereas hamsters deteriorate and die. Cystatin S (a cysteine protease inhibitor) is another example. Rats hesitate to eat diets containing papain (a cysteine protease) or capsaicin (a pungent principle of red pepper), but they ordinarily consume such diets from a few days after the onset of feeding, at which time cystatin S has been newly induced in their saliva. Induction of cystatin with a β-adrenergic agonist accelerates the beginning of eating a papain or capsaicin diet. Cystatin S is perhaps involved in protecting animals from injury caused by exogenous toxic or irritative substances. This article focuses on a few salivary proteins possibly involved in coping with toxic substances in food. In addition, participation of the salivary glands in the metabolism of lysine, an essential amino acid for rats and humans, will be discussed based on our recent data.","subitem_description_type":"Other"}]},"item_10002_full_name_75":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"5680","nameIdentifierScheme":"WEKO"}],"names":[{"name":"KATSUKAWA, HIDEO"}]},{"nameIdentifiers":[{"nameIdentifier":"5377","nameIdentifierScheme":"WEKO"}],"names":[{"name":"SAKO, NORITAKA"}]},{"nameIdentifiers":[{"nameIdentifier":"5543","nameIdentifierScheme":"WEKO"}],"names":[{"name":"NAKASHIMA, KIYOHITO"}]},{"nameIdentifiers":[{"nameIdentifier":"16832","nameIdentifierScheme":"WEKO"}],"names":[{"name":"EGUCHI, KIMIHITO"}]},{"nameIdentifiers":[{"nameIdentifier":"16833","nameIdentifierScheme":"WEKO"}],"names":[{"name":"NAKAHASHI, AKIHIRO"}]},{"nameIdentifiers":[{"nameIdentifier":"16834","nameIdentifierScheme":"WEKO"}],"names":[{"name":"KOBAYASHI, MICHIYA"}]},{"affiliations":[{"affiliationNames":[{"affiliationName":"","lang":"ja"}],"nameIdentifiers":[]}],"familyNames":[{"familyName":"杉村","familyNameLang":"ja"},{"familyName":"SUGIMURA","familyNameLang":"en"}],"givenNames":[{"givenName":"忠敬","givenNameLang":"ja"},{"givenName":"TADATAKA","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8782","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002270072","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002270072"},{"nameIdentifier":"30131387","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30131387"}],"names":[{"name":"杉村, 忠敬","nameLang":"ja"},{"name":"SUGIMURA, TADATAKA","nameLang":"en"}]}]},"item_10002_heading_98":{"attribute_name":"見出し","attribute_value_mlt":[{"subitem_heading_headline":"食物摂取と唾液","subitem_heading_language":"ja"},{"subitem_heading_banner_headline":"Salivary Research","subitem_heading_language":"en"}]},"item_10002_radio_89":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_radio_item":"application/pdf"}]},"item_10002_relation_85":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110004689657","subitem_relation_type_select":"NAID"}}]},"item_10002_relation_86":{"attribute_name":"医中誌文献番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2005089591","subitem_relation_type_select":"ICHUSHI"}}]},"item_10002_source_id_82":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-0072","subitem_source_identifier_type":"ISSN"}]},"item_10002_source_id_84":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053070","subitem_source_identifier_type":"NCID"}]},"item_10002_textarea_76":{"attribute_name":"所属","attribute_value_mlt":[{"subitem_textarea_value":"朝日大学歯学部口腔機能修復学講座口腔生理学分野\nDepartment of Oral Physiology, Division of Oral Functional Science and Rehabilitation, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部口腔機能修復学講座口腔生理学分野\nDepartment of Oral Physiology, Division of Oral Functional Science and Rehabilitation, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部化学教室\nDepartment of Chemistry, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部口腔機能修復学講座口腔生理学分野\nDepartment of Oral Physiology, Division of Oral Functional Science and Rehabilitation, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部口腔機能修復学講座口腔生理学分野\nDepartment of Oral Physiology, Division of Oral Functional Science and Rehabilitation, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部口腔機能修復学講座口腔生理学分野\nDepartment of Oral Physiology, Division of Oral Functional Science and Rehabilitation, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部口腔機能修復学講座口腔生理学分野\nDepartment of Oral Physiology, Division of Oral Functional Science and Rehabilitation, Asahi University School of Dentistry"}]},"item_10002_version_type_95":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"勝川, 秀夫"}],"nameIdentifiers":[{"nameIdentifier":"5673","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000000076051","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000000076051"}]},{"creatorNames":[{"creatorName":"硲, 哲崇"}],"nameIdentifiers":[{"nameIdentifier":"3836","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000090243154","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000090243154"},{"nameIdentifier":"1000090243154","nameIdentifierScheme":"NRID","nameIdentifierURI":" https://rns.nii.ac.jp/d/nr/1000090243154"}]},{"creatorNames":[{"creatorName":"中島, 清人"}],"nameIdentifiers":[{"nameIdentifier":"5539","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000030102122","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000030102122"}]},{"creatorNames":[{"creatorName":"江口, 公人"}],"nameIdentifiers":[{"nameIdentifier":"16829","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000006041172","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000006041172"}]},{"creatorNames":[{"creatorName":"中橋, 章泰"}],"nameIdentifiers":[{"nameIdentifier":"16830","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000006090775","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000006090775"}]},{"creatorNames":[{"creatorName":"小林, 倫也"}],"nameIdentifiers":[{"nameIdentifier":"16831","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000006090776","nameIdentifierScheme":"CiNii 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proteins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Salivary glands","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"食物摂取と唾液","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"食物摂取と唾液"},{"subitem_title":"Food Intake and Saliva","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"21","path":["423"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-01-17"},"publish_date":"2023-01-17","publish_status":"0","recid":"14013","relation_version_is_last":true,"title":["食物摂取と唾液"],"weko_creator_id":"21","weko_shared_id":-1},"updated":"2023-12-25T06:15:51.421855+00:00"}