{"created":"2023-06-23T12:22:13.666042+00:00","id":14048,"links":{},"metadata":{"_buckets":{"deposit":"9a643309-86dc-4507-990d-e176b08f97a7"},"_deposit":{"created_by":21,"id":"14048","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"14048"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00014048","sets":["46:190:429"]},"author_link":["8724","8727","6446","8728","345","535","6442"],"item_10002_biblio_info_77":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-10-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"135","bibliographicPageStart":"127","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"岐阜歯科学会雑誌"},{"bibliographic_title":"The Journal of Gifu Dental Society","bibliographic_titleLang":"en"}]}]},"item_10002_description_80":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"サイトカインには、細胞の増殖、分化、生存に関わり、アポトーシスに対して抑制因子として働くものと誘導因子となるものが示唆されているが、歯形成におけるアポトーシス調節機構は明らかではない。本研究はラット臼歯エナメル芽細胞の増殖期から成熟期におけるアポトーシスの調節機構を知るため、Interleukin（IL）-レセプター（R）からの生存シグナルとInterferon（IFN）-γによるアポトーシス誘導シグナルの局在性を免疫組織化学的に検討した。実験には5,7,10日齢のS.D.系ラットを用い、頭部矢状断の凍結切片を使用した。IFN-γによるアポトーシス誘導シグナルは、特にアポトーシスの見られる移行期エナメル芽細胞近心端および中間層細胞に強い発現が示された。一方、IL-Rからの生存シグナルは、移行期の近心端および中間層細胞ではダウンレギュレーションが見られた。エナメル質形成におけるアポトーシスには、異種のサイトカインからのアポトーシス誘導シグナルと、生存シグナルとが相互に関わり調節していることが示唆された。","subitem_description_type":"Abstract"}]},"item_10002_description_81":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Cytokines and their receptor-linked signaling have been classified as survival and apoptosis factors. It has been known that interleukin (IL)-2, -5, -6 receptors(R) are able to induce survival signaling, while interferon (IFN) γ inhibits cell growth and induces apoptosis signaling in many types of cells. While it has been reported that apoptosis plays an important role in odontogenesis, little is known about the cellular and molecular events involved. Intense immunohistochemical staining for IL-2, -5, -6 R, and survival signaling were co-localized in the cells of pre-ameloblats, presecretory, secretory and early maturation-stage ameloblasts, while they faded in the transition-stage ameloblasts. Intense staining of IFN-γ and induced apoptosis signaling were localized in the transition-stage ameloblasts. These findings suggest that different types of cytokine involved in either survival factor or apoptosis factor, regulate the apoptosis in amelogenesis.","subitem_description_type":"Other"}]},"item_10002_full_name_75":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"6446","nameIdentifierScheme":"WEKO"}],"names":[{"name":"RYUZAKI, KENEI"}]},{"affiliations":[{"affiliationNames":[{"affiliationName":"朝日大学歯学部","lang":"ja"}],"nameIdentifiers":[]}],"familyNames":[{"familyName":"多賀谷","familyNameLang":"ja"},{"familyName":"TAGAYA","familyNameLang":"en"}],"givenNames":[{"givenName":"正俊","givenNameLang":"ja"},{"givenName":"MASATOSHI","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8724","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000004592896","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000004592896"}],"names":[{"name":"多賀谷, 正俊","nameLang":"ja"},{"name":"TAGAYA, MASATOSHI","nameLang":"en"}]},{"nameIdentifiers":[{"nameIdentifier":"8728","nameIdentifierScheme":"WEKO"}],"names":[{"name":"TANASE, SEIZO"}]},{"nameIdentifiers":[{"nameIdentifier":"345","nameIdentifierScheme":"WEKO"}],"names":[{"name":"TAMURA, YASUO"}]}]},"item_10002_heading_98":{"attribute_name":"見出し","attribute_value_mlt":[{"subitem_heading_banner_headline":"原著","subitem_heading_language":"ja"},{"subitem_heading_banner_headline":"ORIGINAL ARTICLES","subitem_heading_language":"en"}]},"item_10002_radio_89":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_radio_item":"application/pdf"}]},"item_10002_relation_85":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110006607213","subitem_relation_type_select":"NAID"}}]},"item_10002_relation_86":{"attribute_name":"医中誌文献番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2007068108","subitem_relation_type_select":"ICHUSHI"}}]},"item_10002_source_id_82":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-0072","subitem_source_identifier_type":"ISSN"}]},"item_10002_source_id_84":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053070","subitem_source_identifier_type":"NCID"}]},"item_10002_textarea_76":{"attribute_name":"所属","attribute_value_mlt":[{"subitem_textarea_value":"朝日大学歯学部口腔構造機能発育学講座小児歯科学分野\nDepartment of Pediatric Dentistry, Division of Oral Structure, Function and Development, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部口腔構造機能発育学講座小児歯科学分野\nDepartment of Pediatric Dentistry, Division of Oral Structure, Function and Development, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部口腔構造機能発育学講座小児歯科学分野\nDepartment of Pediatric Dentistry, Division of Oral Structure, Function and Development, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部口腔構造機能発育学講座小児歯科学分野\nDepartment of Pediatric Dentistry, Division of Oral Structure, Function and Development, Asahi University School of Dentistry"}]},"item_10002_version_type_95":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"龍崎, 健栄"}],"nameIdentifiers":[{"nameIdentifier":"6442","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000006648881","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000006648881"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":"朝日大学歯学部","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"多賀谷, 正俊","creatorNameLang":"ja"},{"creatorName":"TAGAYA, MASATOSHI","creatorNameLang":"en"}],"familyNames":[{"familyName":"多賀谷","familyNameLang":"ja"},{"familyName":"TAGAYA","familyNameLang":"en"}],"givenNames":[{"givenName":"正俊","givenNameLang":"ja"},{"givenName":"MASATOSHI","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8724","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000004592896","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000004592896"}]},{"creatorNames":[{"creatorName":"棚瀬, 精三"}],"nameIdentifiers":[{"nameIdentifier":"8727","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000004593016","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000004593016"}]},{"creatorNames":[{"creatorName":"田村, 康夫"}],"nameIdentifiers":[{"nameIdentifier":"535","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000040113047","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000040113047"},{"nameIdentifier":"40113047","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40113047"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-21"}],"displaytype":"detail","filename":"gifushika332_127135_2006.pdf","filesize":[{"value":"355.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"gifushika332_127135_2006","url":"https://asahi-u.repo.nii.ac.jp/record/14048/files/gifushika332_127135_2006.pdf"},"version_id":"c3e8f35e-b405-4770-8ae4-4b8122dee886"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"アポトーシス","subitem_subject_scheme":"Other"},{"subitem_subject":"エナメル質形成","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-レセプター","subitem_subject_scheme":"Other"},{"subitem_subject":"IFN-γ","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット臼歯","subitem_subject_scheme":"Other"},{"subitem_subject":"シグナル伝達","subitem_subject_scheme":"Other"},{"subitem_subject":"エナメル芽細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫組織化学","subitem_subject_scheme":"Other"},{"subitem_subject":"Sprague-Dawleyラット","subitem_subject_scheme":"Other"},{"subitem_subject":"Apoptosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Amelogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IFN-γ","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rat molor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cytokines","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Interferon Gamma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Interleukin-2","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"エナメル質形成におけるサイトカインによるアポトーシス調節因子の局在性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"エナメル質形成におけるサイトカインによるアポトーシス調節因子の局在性"},{"subitem_title":"Localization of Apoptosis and Survival Factors Mediated by Cytokine in Amelogenesis","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"21","path":["429"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-21"},"publish_date":"2023-02-21","publish_status":"0","recid":"14048","relation_version_is_last":true,"title":["エナメル質形成におけるサイトカインによるアポトーシス調節因子の局在性"],"weko_creator_id":"21","weko_shared_id":-1},"updated":"2024-01-16T05:33:20.702926+00:00"}