{"created":"2023-06-23T12:13:40.042377+00:00","id":1810,"links":{},"metadata":{"_buckets":{"deposit":"95c339e7-4c3a-49fa-971a-7ce4f9944ac1"},"_deposit":{"created_by":19,"id":"1810","owners":[19],"pid":{"revision_id":0,"type":"depid","value":"1810"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00001810","sets":["64:123"]},"author_link":["2269"],"item_10_creator_30":{"attribute_name":"教員氏名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川木, 晴美"}],"nameIdentifiers":[{"nameIdentifier":"2269","nameIdentifierScheme":"WEKO"}]}]},"item_10_date_36":{"attribute_name":"発行又は発表の年月","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-10-24"}]},"item_10_text_38":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_text_value":"Print ISSN: 1792-0981Online ISSN:1792-1015"}]},"item_10_textarea_29":{"attribute_name":"業績分類","attribute_value_mlt":[{"subitem_textarea_value":"学術雑誌論文"}]},"item_10_textarea_31":{"attribute_name":"発行、発表雑誌等、又は発表学会等の名称","attribute_value_mlt":[{"subitem_textarea_value":"Journal of Bone and Mineral Research"}]},"item_10_textarea_32":{"attribute_name":"巻","attribute_value_mlt":[{"subitem_textarea_value":"印刷中"}]},"item_10_textarea_33":{"attribute_name":"号","attribute_value_mlt":[{"subitem_textarea_value":"印刷中"}]},"item_10_textarea_35":{"attribute_name":"単著、共著の別","attribute_value_mlt":[{"subitem_textarea_value":"共著"}]},"item_10_textarea_42":{"attribute_name":"概要","attribute_value_mlt":[{"subitem_textarea_value":"（担当）実験（概要）マウス間葉系間質細胞による免疫抑制機構を検討した。BALB/cマウス脂肪組織由来間質細胞（ASC)は、共培養を行なった抗CD3抗体刺激BALB/cマウス脾細胞のTh1免疫反応であるIFN-γ産生能を顕著に抑制した。この抑制は体刺激脾細胞で活性化されるCD69発現を抑制しなかった。また、ASCの作用は部分的に液性因子を介して発揮されたが、最も効果的な抑制には細胞同士の接触が重要であることが示された。さらに、siＲＮＡを用いた検討により、ASCは自身の細胞表面のMHCクラスＩ抗原複合体を介して、少なくとも部分的に細胞接触による免疫抑制作用を発揮していることが判明した。（共著）Nagaya R, Mizuno-Kamiya M, Takayama E, Kawaki H, Onoe I, Tanabe T, Nagahara K, Kondoh N. "}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"other","resourceuri":"http://purl.org/coar/resource_type/c_1843"}]},"item_title":"Mechanisms of the immunosuppressive effects of mouse adipose tissue-derived mesenchymal stromal cells on mouse alloreactively stimulated spleen cells.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Mechanisms of the immunosuppressive effects of mouse adipose tissue-derived mesenchymal stromal cells on mouse alloreactively stimulated spleen cells."}]},"item_type_id":"10","owner":"19","path":["123"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-02-10"},"publish_date":"2015-02-10","publish_status":"0","recid":"1810","relation_version_is_last":true,"title":["Mechanisms of the immunosuppressive effects of mouse adipose tissue-derived mesenchymal stromal cells on mouse alloreactively stimulated spleen cells."],"weko_creator_id":"19","weko_shared_id":-1},"updated":"2023-06-23T15:00:37.220820+00:00"}