{"created":"2023-06-23T12:13:40.621071+00:00","id":1823,"links":{},"metadata":{"_buckets":{"deposit":"83d4db78-fb79-46d1-ba7c-f37863c139b5"},"_deposit":{"created_by":19,"id":"1823","owners":[19],"pid":{"revision_id":0,"type":"depid","value":"1823"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00001823","sets":["64:123"]},"author_link":["2282"],"item_10_creator_30":{"attribute_name":"教員氏名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川木, 晴美"}],"nameIdentifiers":[{"nameIdentifier":"2282","nameIdentifierScheme":"WEKO"}]}]},"item_10_date_36":{"attribute_name":"発行又は発表の年月","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-09-22"}]},"item_10_textarea_29":{"attribute_name":"業績分類","attribute_value_mlt":[{"subitem_textarea_value":"学会発表"}]},"item_10_textarea_31":{"attribute_name":"発行、発表雑誌等、又は発表学会等の名称","attribute_value_mlt":[{"subitem_textarea_value":"第55回歯科基礎医学会学術大会・総会"}]},"item_10_textarea_32":{"attribute_name":"巻","attribute_value_mlt":[{"subitem_textarea_value":"-"}]},"item_10_textarea_33":{"attribute_name":"号","attribute_value_mlt":[{"subitem_textarea_value":"-"}]},"item_10_textarea_35":{"attribute_name":"単著、共著の別","attribute_value_mlt":[{"subitem_textarea_value":"共同発表"}]},"item_10_textarea_42":{"attribute_name":"概要","attribute_value_mlt":[{"subitem_textarea_value":"（担当）実験（概要）口腔扁平上皮癌細胞(OSCC)株を同系統マウスに移植し、腫瘍の増殖に伴う免疫能の変化を検討した。そのために、C3H マウス由来頬粘膜扁平上皮癌Sq1979(理研BRC)、あるいはサブクローンL-5(高増殖型)を同系統マウス(雄/6 週齢)側腹皮下に移植し、これらの担癌マウスから得られた脾細胞を抗CD3 抗体を用いて刺激培養し、IFN-γ をはじめとするサイトカインの産生能を測定した。その結果、OSCC移植群は、どちらの群もコントロール群に比較して、脾細胞のIFN-γの産生能は低下しており、腫瘍体積と有意な逆相関が認められた。以上の結果より、口腔癌の増大に伴い宿主の抗腫瘍免疫が抑制されることが示された。（共同演者）東康加, 神谷真子, 稲垣俊弘, 川木晴美, 髙山英次, 櫻井学, 智原栄一, 近藤信夫"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"other","resourceuri":"http://purl.org/coar/resource_type/c_1843"}]},"item_title":"マウス口腔扁平上皮癌(Sq1979)の進展が脾細胞IFN-γ産生能に及ぼす影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マウス口腔扁平上皮癌(Sq1979)の進展が脾細胞IFN-γ産生能に及ぼす影響"}]},"item_type_id":"10","owner":"19","path":["123"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-02-10"},"publish_date":"2015-02-10","publish_status":"0","recid":"1823","relation_version_is_last":true,"title":["マウス口腔扁平上皮癌(Sq1979)の進展が脾細胞IFN-γ産生能に及ぼす影響"],"weko_creator_id":"19","weko_shared_id":-1},"updated":"2023-06-23T15:00:27.540305+00:00"}