{"created":"2023-06-23T12:14:05.744361+00:00","id":2417,"links":{},"metadata":{"_buckets":{"deposit":"1ff5410e-89c9-47d2-9cad-437e1551ffe8"},"_deposit":{"created_by":19,"id":"2417","owners":[19],"pid":{"revision_id":0,"type":"depid","value":"2417"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00002417","sets":["64:123"]},"author_link":["2876"],"item_10_creator_30":{"attribute_name":"教員氏名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中尾, 寿奈"}],"nameIdentifiers":[{"nameIdentifier":"2876","nameIdentifierScheme":"WEKO"}]}]},"item_10_date_36":{"attribute_name":"発行又は発表の年月","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-04"}]},"item_10_textarea_29":{"attribute_name":"業績分類","attribute_value_mlt":[{"subitem_textarea_value":"学会発表"}]},"item_10_textarea_31":{"attribute_name":"発行、発表雑誌等、又は発表学会等の名称","attribute_value_mlt":[{"subitem_textarea_value":"第103回日本病理学会"}]},"item_10_textarea_35":{"attribute_name":"単著、共著の別","attribute_value_mlt":[{"subitem_textarea_value":"共同"}]},"item_10_textarea_42":{"attribute_name":"概要","attribute_value_mlt":[{"subitem_textarea_value":"(概要)We have reported that heterogeneous nuclear ribonucleoprotein K was associated with a pre-malignant state during 4-nitroquinoline 1-oxide induced rat tongue carcinogenesis. In this study, to investigate whether this gene is also associated to the human oral cancer, we focused on the hnRNP K gene and examined the relationship between mRNA expressions and the hyperplasia, epithelial dysplasia and SCC samples. We analyzed the expressions of hnRNP K using by immunohistochemistry and RT-PCR. These results showed that the level of hnRNP K mRNA and protein were significantly altered in Dys and SCC samples compared to the normal epithelium. The immunohistochemical expression of hnRNP K was 2-holds higher in the Hyp, Dys and SCC. The hnRNP K mRNA expression level also was 3-holds higher in the Hyp, Dys and SCC. These data suggest that this marker could be for the early detection of pre-malignant lesion of oral cancer."}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"other","resourceuri":"http://purl.org/coar/resource_type/c_1843"}]},"item_title":"hnRNPK is new prospective marker of early detection for tongue carcinogenesis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"hnRNPK is new prospective marker of early detection for tongue carcinogenesis"}]},"item_type_id":"10","owner":"19","path":["123"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-02-20"},"publish_date":"2015-02-20","publish_status":"0","recid":"2417","relation_version_is_last":true,"title":["hnRNPK is new prospective marker of early detection for tongue carcinogenesis"],"weko_creator_id":"19","weko_shared_id":-1},"updated":"2023-06-23T14:54:34.484242+00:00"}