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Drinking-Related Tetrahydroharmans Counteract the Membrane Effects of Local Anesthetic Lidocaine.
https://asahi-u.repo.nii.ac.jp/records/3331
https://asahi-u.repo.nii.ac.jp/records/333152482bb2-5d50-48d3-a5c8-3c574f723c16
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
20908334_3_6_2014 (260.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-04-09 | |||||
| タイトル | ||||||
| タイトル | Drinking-Related Tetrahydroharmans Counteract the Membrane Effects of Local Anesthetic Lidocaine. | |||||
| タイトル | ||||||
| タイトル | Drinking-Related Tetrahydroharmans Counteract the Membrane Effects of Local Anesthetic Lidocaine. | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | drinking | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | local anesthesia | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | reduced efficacy | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | lidocaine | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | tetrahydroharman | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | membrane effect | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Tsuchiya, Hironori
× Tsuchiya, Hironori |
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| 著者別名 |
Mizogami, Maki
× Mizogami, Maki |
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| 所属 | ||||||
| Department of Dental Basic Education, Asahi University School of Dentistry, Mizuho, Gifu 501-0296, Japan | ||||||
| 所属 | ||||||
| Department of Anesthesiology and Reanimatology, University of Fukui Faculty of Medical Sciences, Eiheiji-cho, Fukui 910-1193, Japan | ||||||
| 書誌情報 |
en : Journal of drug and alcohol research 巻 3, p. 6-6, 発行日 2014-12-10 |
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| 出版者 | ||||||
| Ashdin publishing | ||||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | There is a general consensus in dentistry that successful local anesthesia is frequently difficult in habitual drinkers and alcoholic patients. Neuro-active tetrahydroharmans increase in human body fluids and tissues by consuming alcoholic beverages. To understand such reduced anesthetic efficacy by the drug interaction hypothesis, we studied the influences of drinking-related tetrahydroharmans on membrane fluidization as one of local anesthetic mechanisms. Liposomal membranes prepared with phosphatidylcholine and cholesterol were treated with lidocaine and different tetrahydroharmans separately and in combination, followed by measuring fluorescence polarization to determine their induced changes in membrane fluidity. In contrast to 0.1–2 mg/mL lidocaine, tetrahydroharmans decreased the fluidity of membrane preparations at ∼25 μg/mL with the potency being 1,2,3,4-tetrahydroharman ≫ 1,2,3,4-tetrahydronorharman. 1,2,3,4-Tetrahydroharman counteracted the membrane-fluidizing effects of 1 mg/mL lidocaine at physiologically relevant 0.25–2.5 ng/mL, whereas neither its 6-hydroxyl nor 7-hydroxyl metabolite did at 25–200 ng/mL. Such counteraction at a membrane lipid level may be responsible for the reduction of local anesthetic efficacy in drinkers because 1,2,3,4-tetrahydroharman increases in vivo by ingesting alcoholic beverages. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2090-8334 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.4303/jdar/235887 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
