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Lipid peroxidation - inhibitory effects of perioperatively used drugs associated with their membrane interactions.
https://asahi-u.repo.nii.ac.jp/records/3335
https://asahi-u.repo.nii.ac.jp/records/3335326b3ef8-c89d-4196-8703-779eab417f8d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
21468389_3_9198_2014 (452.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-04-09 | |||||
| タイトル | ||||||
| タイトル | Lipid peroxidation - inhibitory effects of perioperatively used drugs associated with their membrane interactions. | |||||
| タイトル | ||||||
| タイトル | Lipid peroxidation - inhibitory effects of perioperatively used drugs associated with their membrane interactions. | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Biomimetic membrane | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Lipid peroxidation | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Membrane interaction | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Nitrative stress | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Oxidative stress | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Perioperative drug | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Tsuchiya, Hironori
× Tsuchiya, Hironori |
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| 所属 | ||||||
| Department of Dental Basic Education, Asahi University School of Dentistry, Mizuho, Japan. | ||||||
| 書誌情報 |
en : Oxidants and antioxidants in medical science 巻 3, 号 2, p. 91-98, 発行日 2014-05-02 |
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| 出版者 | ||||||
| SAGEYA PUBLISHING | ||||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: Oxidative/nitrative stress, an imbalance between oxidant production and antioxidant defense in the biological system, is induced not only by various diseases but also by anesthesia and surgical trauma. Since the choice of drugs is expected to reduce oxidative/nitrative stress in the perioperative period, the lipid peroxidation inhibition by different drugs associated with surgery was studied together with investigating one of their possible mechanisms. Methods: Lipid peroxidation-inhibitory effects were fluorometrically determined using the liposomes of diphenyl-1-pyrenylphosphine-incorporated lipid bilayers which were treated with 10-200 μM drugs and reference antioxidants, and then peroxidized with 20 μM peroxynitrite. Membrane interactions were evaluated by the drug- and antioxidant-induced changes in membrane fluidity which were determined by measuring the fluorescence polarization of 1,6-diphenyl-1,3,5-hexatriene-labeled biomimetic membranes after treating with drugs and antioxidants at 1-200 μM. Results: All of the tested drugs concentration-dependently inhibited peroxynitrite-induced lipid peroxidation as well as antioxidant α-tocopherol, quercetin and (–)-epigallocatechin-3-gallate. The inhibition at 10 μM was greatest in propofol, followed by guaiacol, thiopental, thymol, phenol, midazolam, diazepam, lidocaine, eugenol, procaine, bupivacaine, ropivacaine, sevoflurane, ketamine, mepivacaine and prilocaine. Antioxidant drugs including propofol, local anesthetics and phenol derivatives, and reference antioxidants interacted with biomimetic membranes consisting of phospholipids and cholesterol to modify the membrane fluidity, while their membrane-interacting potencies did not necessarily correlate to their lipid peroxidation-inhibiting ones, suggesting that the interaction between drugs and membrane lipid bilayers, at least in part, underlies the lipid peroxidation inhibition. Conclusion: In addition to their inherent effects, propofol and other drugs to inhibit lipid peroxidation may be protective against perioperative oxidative/nitrative stress. The membrane interaction could be a guide for discovering novel antioxidant drugs. |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2146-8389 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.5455/oams.020414.or.061 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
