{"created":"2023-06-23T12:14:53.195762+00:00","id":3487,"links":{},"metadata":{"_buckets":{"deposit":"565263bb-0fdf-4444-801a-da236a0bd881"},"_deposit":{"created_by":21,"id":"3487","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"3487"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00003487","sets":["46:190:193"]},"author_link":["4042","4041","1767","4043","4039","1290","3967","1768"],"item_10002_biblio_info_77":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-02-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"263","bibliographicPageStart":"258","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"岐阜歯科学会雑誌"},{"bibliographic_title":"The Journal of Gifu Dental Society","bibliographic_titleLang":"en"}]}]},"item_10002_description_80":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"重層扁平上皮は高度に分化した組織であるが、これを発生由来とする扁平上皮癌ではその分化程度により、本来の組織形態とは異なる形質を発現することが知られている。本研究はこれらの形質発現の変化の中で上皮間葉転換の一つとして知られる扁平上皮から紡錘形の間葉系への分化の可能性とその癌細胞の浸潤性への関連を探るため、超微細構造を含む形態的な変化や細胞間接着因子のカドヘリンとカテニン、細胞外基質のヒアルロン酸と大きく関わり、また腫瘍の浸潤や細胞活性にも関わると言われているCD44ファミリーについて免疫組織化学的に検索した。歯肉に生じた扁平上皮癌で頸部リンパ節転移を示した一例を材料にその検索を行ったところ、原発巣における紡錘形を示す癌細胞は超微細形態的にも紡錘形を示すがトノフィラメントやデスモゾーム構造を有した上皮細胞としての性格を維持しており、また免疫染色においても、ケラチン発現の維持とEMAの減少に加えて間葉成分のビメンチン発現を認めたが、細胞間接着に関する異常は認めなかった。一方、CD44ファミリーのバリアント6(CD44v6)は紡錘形を示す癌細胞に強い発現を示し、この発現と癌細胞の浸潤が強く示唆された。","subitem_description_type":"Abstract"}]},"item_10002_full_name_75":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"4039","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000000740047","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000000740047"}],"names":[{"name":"庵原, 明倫"}]},{"affiliations":[{"affiliationNames":[{"affiliationName":"朝日大学歯学部","lang":"ja"}],"nameIdentifiers":[]}],"familyNames":[{"familyName":"永山","familyNameLang":"ja"},{"familyName":"NAGAYAMA","familyNameLang":"en"}],"givenNames":[{"givenName":"元彦","givenNameLang":"ja"},{"givenName":"MOTOHIKO","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1290","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000050298436","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000050298436"},{"nameIdentifier":"50298436","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50298436"}],"names":[{"name":"永山, 元彦","nameLang":"ja"},{"name":"NAGAYAMA, MOTOHIKO","nameLang":"en"}]},{"affiliations":[{"affiliationNames":[{"affiliationName":"朝日大学","lang":"ja"}],"nameIdentifiers":[]}],"familyNames":[{"familyName":"松原","familyNameLang":"ja"},{"familyName":"MATSUBARA","familyNameLang":"en"}],"givenNames":[{"givenName":"誠","givenNameLang":"ja"},{"givenName":"MAKOTO","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1767","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000413854863","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000413854863"}],"names":[{"name":"松原, 誠","nameLang":"ja"},{"name":"MATSUBARA, MAKOTO","nameLang":"en"}]},{"nameIdentifiers":[{"nameIdentifier":"4041","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000251869788","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000251869788"}],"names":[{"name":"川原田, 幸司"}]},{"nameIdentifiers":[{"nameIdentifier":"1768","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000251869790","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000251869790"}],"names":[{"name":"諏訪, 裕彦"}]},{"nameIdentifiers":[{"nameIdentifier":"4042","nameIdentifierScheme":"WEKO"}],"names":[{"name":"江原, 道子"}]},{"affiliations":[{"affiliationNames":[{"affiliationName":"朝日大学","lang":"ja"}],"nameIdentifiers":[]}],"familyNames":[{"familyName":"式守","familyNameLang":"ja"},{"familyName":"SHIKIMORI","familyNameLang":"en"}],"givenNames":[{"givenName":"道夫","givenNameLang":"ja"},{"givenName":"MICHIO","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3967","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000006648893","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000006648893"},{"nameIdentifier":"70154193","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70154193"}],"names":[{"name":"式守, 道夫","nameLang":"ja"},{"name":"SHIKIMORI, MICHIO","nameLang":"en"}]},{"nameIdentifiers":[{"nameIdentifier":"4043","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000020305139","nameIdentifierScheme":"NRID","nameIdentifierURI":" https://rns.nii.ac.jp/d/nr/1000020305139"}],"names":[{"name":"田沼, 順一"}]}]},"item_10002_radio_89":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_radio_item":"application/pdf"}]},"item_10002_relation_86":{"attribute_name":"医中誌文献番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2015007439","subitem_relation_type_select":"ICHUSHI"}}]},"item_10002_source_id_82":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-0072","subitem_source_identifier_type":"ISSN"}]},"item_10002_source_id_84":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053070","subitem_source_identifier_type":"NCID"}]},"item_10002_textarea_76":{"attribute_name":"所属","attribute_value_mlt":[{"subitem_textarea_value":"Ihara Machinaka Dental Clinic"},{"subitem_textarea_value":"Department of Oral Pathology, Division of Oral Pathogenesis and Disease Control, Asahi University School of Dentistry"},{"subitem_textarea_value":"Department of Oral and Maxillofacial Surgery, Division of Oral Pathogenesis and Disease Control, Asahi University School of Dentistry"},{"subitem_textarea_value":"Department of Oral Pathology, Division of Oral Pathogenesis and Disease Control, Asahi University School of Dentistry"},{"subitem_textarea_value":"Department of Oral Pathology, Division of Oral Pathogenesis and Disease Control, Asahi University School of Dentistry"},{"subitem_textarea_value":"Department of Oral Pathology, Division of Oral Pathogenesis and Disease Control, Asahi University School of Dentistry"},{"subitem_textarea_value":"Department of Oral and Maxillofacial Surgery, Division of Oral Pathogenesis and Disease Control, Asahi University School of Dentistry"},{"subitem_textarea_value":"Department of Oral Pathology, Division of Oral Pathogenesis and Disease Control, Asahi University School of Dentistry"}]},"item_10002_version_type_95":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"IHARA, AKINORI"}],"nameIdentifiers":[{"nameIdentifier":"4039","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000000740047","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000000740047"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":"朝日大学歯学部","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"永山, 元彦","creatorNameLang":"ja"},{"creatorName":"NAGAYAMA, MOTOHIKO","creatorNameLang":"en"}],"familyNames":[{"familyName":"永山","familyNameLang":"ja"},{"familyName":"NAGAYAMA","familyNameLang":"en"}],"givenNames":[{"givenName":"元彦","givenNameLang":"ja"},{"givenName":"MOTOHIKO","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1290","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000050298436","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000050298436"},{"nameIdentifier":"50298436","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50298436"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":"朝日大学","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"松原, 誠","creatorNameLang":"ja"},{"creatorName":"MATSUBARA, MAKOTO","creatorNameLang":"en"}],"familyNames":[{"familyName":"松原","familyNameLang":"ja"},{"familyName":"MATSUBARA","familyNameLang":"en"}],"givenNames":[{"givenName":"誠","givenNameLang":"ja"},{"givenName":"MAKOTO","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1767","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000413854863","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000413854863"}]},{"creatorNames":[{"creatorName":"KAWARADA, KOUJI"}],"nameIdentifiers":[{"nameIdentifier":"4041","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000251869788","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000251869788"}]},{"creatorNames":[{"creatorName":"SUWA, HIROHIKO"}],"nameIdentifiers":[{"nameIdentifier":"1768","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000251869790","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000251869790"}]},{"creatorNames":[{"creatorName":"EHARA, MICHIKO"}],"nameIdentifiers":[{"nameIdentifier":"4042","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":"朝日大学","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"式守, 道夫","creatorNameLang":"ja"},{"creatorName":"SHIKIMORI, MICHIO","creatorNameLang":"en"}],"familyNames":[{"familyName":"式守","familyNameLang":"ja"},{"familyName":"SHIKIMORI","familyNameLang":"en"}],"givenNames":[{"givenName":"道夫","givenNameLang":"ja"},{"givenName":"MICHIO","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3967","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000006648893","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000006648893"},{"nameIdentifier":"70154193","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70154193"}]},{"creatorNames":[{"creatorName":"TANUMA, JUN-ICHI"}],"nameIdentifiers":[{"nameIdentifier":"4043","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000020305139","nameIdentifierScheme":"NRID","nameIdentifierURI":" https://rns.nii.ac.jp/d/nr/1000020305139"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-11-25"}],"displaytype":"detail","filename":"gifushika403_258263_2014.pdf","filesize":[{"value":"3.2 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"gifushika403_258263_2014","url":"https://asahi-u.repo.nii.ac.jp/record/3487/files/gifushika403_258263_2014.pdf"},"version_id":"31bfd062-a70b-453e-8741-0aafc89812bf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"舌腫瘍(外科的療法,病理学)","subitem_subject_scheme":"Other"},{"subitem_subject":"舌切除術","subitem_subject_scheme":"Other"},{"subitem_subject":"扁平上皮癌(外科的療法,病理学)","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫組織化学","subitem_subject_scheme":"Other"},{"subitem_subject":"CD44抗原","subitem_subject_scheme":"Other"},{"subitem_subject":"超微構造","subitem_subject_scheme":"Other"},{"subitem_subject":"透過型電子顕微鏡検査法","subitem_subject_scheme":"Other"},{"subitem_subject":"上皮間葉転換","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト","subitem_subject_scheme":"Other"},{"subitem_subject":"高齢者(65〜79)","subitem_subject_scheme":"Other"},{"subitem_subject":"女","subitem_subject_scheme":"Other"},{"subitem_subject":"歯学","subitem_subject_scheme":"Other"},{"subitem_subject":"squamous cell carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"epithelial-mesenchymal transition","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"immunohistochemistry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ultrastructure","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"扁平上皮癌における上皮間葉転換現象とこれに関与する分子: 1症例の舌癌における検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"扁平上皮癌における上皮間葉転換現象とこれに関与する分子: 1症例の舌癌における検討"},{"subitem_title":"Epithelial-mesenchymal transition in oral squamous cell carcinoma of the gingiva: An immunohistochemical and ultrastructual case study.","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"21","path":["193"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-11-25"},"publish_date":"2015-11-25","publish_status":"0","recid":"3487","relation_version_is_last":true,"title":["扁平上皮癌における上皮間葉転換現象とこれに関与する分子: 1症例の舌癌における検討"],"weko_creator_id":"21","weko_shared_id":-1},"updated":"2024-01-17T07:09:15.385355+00:00"}