{"created":"2023-06-23T12:15:23.357334+00:00","id":5112,"links":{},"metadata":{"_buckets":{"deposit":"2ae5d09e-b2c5-4003-a8d4-69d620ac2b7b"},"_deposit":{"created_by":21,"id":"5112","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"5112"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00005112","sets":["46:190:339"]},"author_link":["4093","7162","6391","8651","1290","5916","8653","4274","8652"],"item_10002_biblio_info_77":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-10-24","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"84","bibliographicPageStart":"73","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"岐阜歯科学会雑誌"},{"bibliographic_title":"The journal of Gifu Dental Society","bibliographic_titleLang":"en"}]}]},"item_10002_description_80":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"口腔組織を構成している上皮組織(口腔粘膜上皮、唾液腺上皮、歯原性上皮)、および唾液腺上皮や歯原性上皮から発症する腫瘍ならびに嚢胞におけるサイトケラチン(pan-CK、CK7、CK8、CK10、CK13、CK14、CK18およびCK19)の発現を免疫組織化学的に検索した結果、CK8、CK14およびCK19は正常上皮、腫瘍実質、嚢胞の裏装上皮のすべてに発現した。しかし、CK7は歯原性上皮と歯原性腫瘍および歯原性嚢胞に発現がなく、それ以外のすべての正常および病変上皮はこれを発現した。CK10は一部の口腔粘膜上皮の角化層付近とglandular odontogenic cyst(GOC)に発現するものがみられた以外はすべて陰性であった。また、CK18も歯原性上皮の一部に極めて弱い発現性を示す例があった。しかし、GOCは例外的に強く発現した。GOCは今回検出の対象としたすべてのサイトケラチンを発現し、他の病変と比べてかなり特殊な病変とみなすことができた。組織学的に、このGOCと類似性の高い顎中心性粘表皮癌は、CK18が非発現であるほかはGOCと同様の発現性を示した。ムチカルミン染色では、正常唾液腺上皮と唾液腺腫瘍に染色陽性を示し、同時にGOCの裏装上皮にも陽性を示した。これらの所見から、口腔を構成する上皮細胞は、すべてがCK8とCK14を基本的な細胞骨格としていこと、その他のサイトケラチンは上皮の種類によって質的(種類)あるいは量的(発現の強さ)に差異を示し、これは分化の違いを反映しているものと考えられた。また、サイトケラチン発現性とムチカルミン染色性から、GOCは粘表皮癌と近縁の病変、あるいは前駆病変の可能性であることも示唆された。\nMore than 20 types of cytokeratins(CKs), which are well known as intermediate filaments of epithelial cells, have been analyzed in various types of epithelial cells. The expression pattern of proteins differs with the kind of epithelium associated with cell differentiation. Therefore, the peculiarity of CK expressions can be applied to the differential diagnosis of neoplasms arising from various types of epithelial cells. To clarify the pattern of cytokeratins in the cells comprising the oral epithelial tissues and lesions originating from various epithelial tissues, we performed immunohitochemical analyses of the expression pattern of CKs(pan-CK, CK7, CK8, CK10, CK13, CK14, CK18, and CK19). Further, we also analyzed the nature of CKs expression and mucicarmine staining to determine the difference between the bony central mucoepidermoid carcinoma(CMEC)arised from mandible and the glandular odontogenic cyst(GOC). CK8,CK14, and CK19 were expressed in the epithelial cells of all specimens in this study. CK7 was expressed in the epithelial cells of normal mucosal and salivary gland, but was not expressed in the odontogenic tumors and odonotogenic cysts epithelia. CK10 was expressed only in a part of oral mucosal epithelium and GOC lining epithelium. However, the intensity of CK10 expression was weak in both types of epithelial cells. The expression of CK18 also showed a tendency to be limited to several types of cells such as salivary gland ductal cells and GOC lining epithelial cells. These findings indicate that epithelial cells in the oral region including those from abnormal tissue express the same CKs, and different sorts of CKs, suggesting that these features of the CK expression dependant on variations in cellular differentiation among the oral epithelium. GOC lining epithelium showed a specific expression pattern that expressed all CKs. It was also peculiar that the expression patterns of CKs in GOC were similar to those of mucoepidermoid carcinoma cells, and both lesions exhibited mucicarmine-positive staining. These findings suggest that these lesions are related to each other and/or GOC is the pre-existing or pre-cancerous lesion of central mucoepidermoid carcinoma.","subitem_description_type":"Abstract"}]},"item_10002_full_name_75":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"7162","nameIdentifierScheme":"WEKO"}],"names":[{"name":"KUWABARA, HIROAKI"}]},{"nameIdentifiers":[{"nameIdentifier":"5916","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ITO, NORIAKI"}]},{"nameIdentifiers":[{"nameIdentifier":"6391","nameIdentifierScheme":"WEKO"}],"names":[{"name":"SATO, 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of Oral Pathology, Division of Oral Pathogenesis and Disease Control, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部口腔病態医療学講座口腔病理学分野\nDepartment of Oral Pathology, Division of Oral Pathogenesis and Disease Control, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部口腔病態医療学講座口腔病理学分野\nDepartment of Oral Pathology, Division of Oral Pathogenesis and Disease Control, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部口腔病態医療学講座口腔病理学分野\nDepartment of Oral Pathology, Division of Oral Pathogenesis and Disease Control, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部口腔病態医療学講座口腔病理学分野\nDepartment of Oral Pathology, Division of Oral Pathogenesis and Disease Control, Asahi University School of Dentistry"}]},"item_10002_version_type_95":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"桑原, 広明"}],"nameIdentifiers":[{"nameIdentifier":"8651","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000016501545","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000016501545"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"伊藤, 範明","creatorNameLang":"ja"},{"creatorName":"ITO, NORIAKI","creatorNameLang":"en"}],"familyNames":[{"familyName":"伊藤","familyNameLang":"ja"},{"familyName":"ITO","familyNameLang":"en"}],"givenNames":[{"givenName":"範明","givenNameLang":"ja"},{"givenName":"NORIAKI","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8652","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000004594788","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000004594788"}]},{"creatorNames":[{"creatorName":"佐藤, 勝"}],"nameIdentifiers":[{"nameIdentifier":"8653","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000004584086","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000004584086"},{"nameIdentifier":"1000070154101","nameIdentifierScheme":"NRID","nameIdentifierURI":" https://rns.nii.ac.jp/d/nr/1000070154101"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":"朝日大学歯学部","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"永山, 元彦","creatorNameLang":"ja"},{"creatorName":"NAGAYAMA, MOTOHIKO","creatorNameLang":"en"}],"familyNames":[{"familyName":"永山","familyNameLang":"ja"},{"familyName":"NAGAYAMA","familyNameLang":"en"}],"givenNames":[{"givenName":"元彦","givenNameLang":"ja"},{"givenName":"MOTOHIKO","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1290","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000050298436","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000050298436"},{"nameIdentifier":"50298436","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50298436"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"竹内, 宏","creatorNameLang":"ja"},{"creatorName":"TAKEUCHI, HIROSHI","creatorNameLang":"en"}],"familyNames":[{"familyName":"竹内","familyNameLang":"ja"},{"familyName":"TAKEUCHI","familyNameLang":"en"}],"givenNames":[{"givenName":"宏","givenNameLang":"ja"},{"givenName":"HIROSHI","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4093","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000040102123","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000040102123"},{"nameIdentifier":"40102123","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40102123"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-08-09"}],"displaytype":"detail","filename":"gifushika362_7384_2009.pdf","filesize":[{"value":"924.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"gifushika362_7384_2009","url":"https://asahi-u.repo.nii.ac.jp/record/5112/files/gifushika362_7384_2009.pdf"},"version_id":"eb5c090a-2f86-4f9f-99d0-5301e551f34e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"サイトケラチン","subitem_subject_scheme":"Other"},{"subitem_subject":"腺性歯原性嚢胞","subitem_subject_scheme":"Other"},{"subitem_subject":"唾液腺腫瘍","subitem_subject_scheme":"Other"},{"subitem_subject":"歯原性腫瘍","subitem_subject_scheme":"Other"},{"subitem_subject":"歯原性嚢胞","subitem_subject_scheme":"Other"},{"subitem_subject":"エナメル上皮腫","subitem_subject_scheme":"Other"},{"subitem_subject":"上皮","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫組織化学","subitem_subject_scheme":"Other"},{"subitem_subject":"cytokeratin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"glandular odontogenic cyst","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"salivary gland tumor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"odontogenic tumor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"odontogenic cyst","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"keratins","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"口腔の各種上皮組織と上皮性病変のサイトケラチンの発現性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"口腔の各種上皮組織と上皮性病変のサイトケラチンの発現性"},{"subitem_title":"Expression of Cytokeratins in Various Epithelia and Epithelial Lesions in the Oral Region","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"21","path":["339"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-08-09"},"publish_date":"2016-08-09","publish_status":"0","recid":"5112","relation_version_is_last":true,"title":["口腔の各種上皮組織と上皮性病変のサイトケラチンの発現性"],"weko_creator_id":"21","weko_shared_id":-1},"updated":"2024-01-17T07:09:12.382743+00:00"}