{"created":"2023-06-23T12:15:26.001675+00:00","id":5166,"links":{},"metadata":{"_buckets":{"deposit":"cdb9a5fb-28f3-46e8-984e-dd869c1346d2"},"_deposit":{"created_by":21,"id":"5166","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"5166"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00005166","sets":["46:190:344"]},"author_link":["8699","8697","8700","8701","8703","3956","4093","8696","4274","3405","1290","8698","8702","8705","3953","8704"],"item_10002_biblio_info_77":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-02-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"104","bibliographicPageStart":"96","bibliographicVolumeNumber":"35","bibliographic_titles":[{"bibliographic_title":"岐阜歯科学会雑誌"},{"bibliographic_title":"The journal of Gifu Dental Society","bibliographic_titleLang":"en"}]}]},"item_10002_description_80":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"頭蓋底は頭蓋骨の一部として脳と頭頸顔面骨の間に神経頭蓋底として存在する。この骨化様式は軟骨性骨化であり、同時に頭蓋底を構成する骨の成長を制御することになる。ヒトの場合、頭蓋底は後頭骨基底部、蝶形骨、篩骨ならびに前頭骨から構成される。頭蓋底には軟骨結合と呼ばれる非常に特徴的な軟骨組織がこれら骨間に存在し、骨化成長点として、特に前後軸方向への頭蓋底の伸長に寄与すると同時に、頭蓋顔面骨の成長全体に重要な役割を担っている。組織学的に頭蓋底の軟骨結合は、その中央部に静止あるいは休止軟骨細胞層が存在し、これを前後で挟むように増殖軟骨細胞層、前肥大軟骨細胞層および肥大軟骨細胞層の順に規則正しく軟骨細胞が配列する。最近の遺伝子的研究から、非常に興味ある知見が報告されているが、軟骨結合の生物学的な意義を含めた謎は解決されていないことが多い。特に頭蓋底の形態的な変化を示す発育異常として知られる唇裂/口蓋裂、Crouzon症候群、Apert症候群や鎖骨頭蓋異形成症などの詳細を理解する上で、軟骨結合の重要性は高い。この総説は、これまでに知られている先天異常を含む発育異常の中で、特に頭蓋底の変化によって頭蓋顔面に異常を来す疾患を紹介するとともに、これらの発症する分子メカニズムのひとつとして重要であると考えられているIndian hedgehog(Ihh)やWnt/β-cateninのシグナルを、マウスの軟骨結合を中心にまとめたものである。著者らはこれらの成果や発育異常の発症メカニズムの解明が将来、治療を目的とした分野に発展することを期待して止まない。","subitem_description_type":"Abstract"}]},"item_10002_description_81":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The cranial base is a part of the craniofacial skeleton. It is located between the brain and the craniofacial bones andforms a floor of the neurocranium. The cranial base is formed by endochondral ossification and is established by thecoordinated development and growth of several skeletal elements. In human the cranial base is composed of thebasioccipital, sphenoid, ethmoid and frontal bones. The cranial base is characterized by the presence of the synchondroses,cartilaginous segments persisting between the ossification centers, which are essential growth centers of theanterior-posterior cranial base elongation. The synchondroses play a significant role for the overall organization andthe craniofacial development. Histologically, the synchondroses consist of a central resting zone of chondrocytes,mirror-image growth plates arranged in opposing direction, which includes proliferative, pre-hypertrophic and hypertrophic zone of chondrocytes. Recently, several genetic studies have shown to understand this intriguing nature,however, much remains to be understood about synchondrosis developmental biology. Particularly with regard to howthey form and acquire their characteristic organization and locations along the cranial base, what factors maintaintheir function, and what changes in these fundamental mechanisms may contribute or lead to craniofacial developmentaldiseases, including malformations such as cleft lip/palate, Crouzon and Apert syndromes, and cleidocranial dysplasias.In this review, we summarize recent studies of congenital craniofacial disorders caused by cranial base malformation,and introduce recent studies focused on the roles of Indian hedgehog( Ihh)and Wnt/β-catenin signaling inmouse synchondrosis development and function.","subitem_description_type":"Other"}]},"item_10002_full_name_75":{"attribute_name":"著者別名","attribute_value_mlt":[{"affiliations":[{"affiliationNames":[{"affiliationName":"朝日大学歯学部","lang":"ja"}],"nameIdentifiers":[]}],"familyNames":[{"familyName":"永山","familyNameLang":"ja"},{"familyName":"NAGAYAMA","familyNameLang":"en"}],"givenNames":[{"givenName":"元彦","givenNameLang":"ja"},{"givenName":"MOTOHIKO","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1290","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000050298436","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000050298436"},{"nameIdentifier":"50298436","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50298436"}],"names":[{"name":"永山, 元彦","nameLang":"ja"},{"name":"NAGAYAMA, MOTOHIKO","nameLang":"en"}]},{"nameIdentifiers":[{"nameIdentifier":"8702","nameIdentifierScheme":"WEKO"}],"names":[{"name":"KOYAMA, EIKI"}]},{"nameIdentifiers":[{"nameIdentifier":"8703","nameIdentifierScheme":"WEKO"}],"names":[{"name":"SHIBUKAWA, YOSHIHIRO"}]},{"nameIdentifiers":[{"nameIdentifier":"8704","nameIdentifierScheme":"WEKO"}],"names":[{"name":"NAKAZAWA, JUNKO"}]},{"nameIdentifiers":[{"nameIdentifier":"8705","nameIdentifierScheme":"WEKO"}],"names":[{"name":"IMAIZUMI, YOSHINOBU"}]},{"nameIdentifiers":[{"nameIdentifier":"3953","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005795131","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005795131"}],"names":[{"name":"TSUKAHARA, TAKASHI"}]},{"affiliations":[{"affiliationNames":[{"affiliationName":"朝日大学歯学部","lang":"ja"}],"nameIdentifiers":[]}],"familyNames":[{"familyName":"日下","familyNameLang":"ja"},{"familyName":"KUSAKA","familyNameLang":"en"}],"givenNames":[{"givenName":"義章","givenNameLang":"ja"},{"givenName":"YOSHIAKI","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8700","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000040205068","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000040205068"},{"nameIdentifier":"40205068","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40205068"}],"names":[{"name":"日下, 義章","nameLang":"ja"},{"name":"KUSAKA, YOSHIAKI","nameLang":"en"}]},{"nameIdentifiers":[{"nameIdentifier":"3956","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000261043356","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000261043356"}],"names":[{"name":"OHTOMO, KATSUYUKI"}]},{"nameIdentifiers":[{"nameIdentifier":"4274","nameIdentifierScheme":"WEKO"}],"names":[{"name":"TAKEUCHI, HIROSHI"}]}]},"item_10002_radio_89":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_radio_item":"application/pdf"}]},"item_10002_relation_85":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110007491630","subitem_relation_type_select":"NAID"}}]},"item_10002_relation_86":{"attribute_name":"医中誌文献番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2009169381","subitem_relation_type_select":"ICHUSHI"}}]},"item_10002_source_id_82":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-0072","subitem_source_identifier_type":"ISSN"}]},"item_10002_source_id_84":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053070","subitem_source_identifier_type":"NCID"}]},"item_10002_textarea_76":{"attribute_name":"所属","attribute_value_mlt":[{"subitem_textarea_value":"朝日大学歯学部口腔病態医療学講座口腔病理学分野\nDepartment of Oral Pathology, Division of Oral Pathogensesis and Disease Control, Asahi University School of Dentistry"},{"subitem_textarea_value":"Department of Orthopaedic Surgery, Thomas Jefferson University College of Medicine"},{"subitem_textarea_value":"東京歯科大学歯周病学講座\nDepartment of Periodontology, Tokyo Dental College"},{"subitem_textarea_value":"朝日大学歯学部附属村上記念病院一般外科学分野整形外科学分野\nDivision of Surgery, Department of General Medicine, Murakami-Memorial Hospital, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部附属村上記念病院一般外科学分野整形外科学分野\nDivision of Surgery, Department of General Medicine, Murakami-Memorial Hospital, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部附属村上記念病院一般外科学分野整形外科学分野\nDivision of Surgery, Department of General Medicine, Murakami-Memorial Hospital, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部附属村上記念病院一般外科学分野整形外科学分野\nDivision of Surgery, Department of General Medicine, Murakami-Memorial Hospital, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部附属村上記念病院一般外科学分野整形外科学分野\nDivision of Surgery, Department of General Medicine, Murakami-Memorial Hospital, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部口腔病態医療学講座口腔病理学分野\nDepartment of Oral Pathology, Division of Oral Pathogensesis and Disease Control, Asahi University School of Dentistry"}]},"item_10002_version_type_95":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":"朝日大学歯学部","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"永山, 元彦","creatorNameLang":"ja"},{"creatorName":"NAGAYAMA, MOTOHIKO","creatorNameLang":"en"}],"familyNames":[{"familyName":"永山","familyNameLang":"ja"},{"familyName":"NAGAYAMA","familyNameLang":"en"}],"givenNames":[{"givenName":"元彦","givenNameLang":"ja"},{"givenName":"MOTOHIKO","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1290","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000050298436","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000050298436"},{"nameIdentifier":"50298436","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50298436"}]},{"creatorNames":[{"creatorName":"Koyama, Eiki"}],"nameIdentifiers":[{"nameIdentifier":"8696","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000014650597","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000014650597"}]},{"creatorNames":[{"creatorName":"渋川, 義宏"}],"nameIdentifiers":[{"nameIdentifier":"8697","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000050297347","nameIdentifierScheme":"NRID","nameIdentifierURI":" https://rns.nii.ac.jp/d/nr/1000050297347"}]},{"creatorNames":[{"creatorName":"中澤, 純子"}],"nameIdentifiers":[{"nameIdentifier":"8698","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000014650599","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000014650599"}]},{"creatorNames":[{"creatorName":"今泉, 佳宣"}],"nameIdentifiers":[{"nameIdentifier":"8699","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000006012160","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000006012160"}]},{"creatorNames":[{"creatorName":"塚原, 隆司"}],"nameIdentifiers":[{"nameIdentifier":"3405","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005795131","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005795131"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":"朝日大学歯学部","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"日下, 義章","creatorNameLang":"ja"},{"creatorName":"KUSAKA, YOSHIAKI","creatorNameLang":"en"}],"familyNames":[{"familyName":"日下","familyNameLang":"ja"},{"familyName":"KUSAKA","familyNameLang":"en"}],"givenNames":[{"givenName":"義章","givenNameLang":"ja"},{"givenName":"YOSHIAKI","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8700","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000040205068","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000040205068"},{"nameIdentifier":"40205068","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40205068"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"大友, 克之","creatorNameLang":"ja"},{"creatorName":"OTOMO, KATSUYUKI","creatorNameLang":"en"}],"familyNames":[{"familyName":"大友","familyNameLang":"ja"},{"familyName":"OTOMO","familyNameLang":"en"}],"givenNames":[{"givenName":"克之","givenNameLang":"ja"},{"givenName":"KATSUYUKI","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8701","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002270022","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002270022"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"竹内, 宏","creatorNameLang":"ja"},{"creatorName":"TAKEUCHI, HIROSHI","creatorNameLang":"en"}],"familyNames":[{"familyName":"竹内","familyNameLang":"ja"},{"familyName":"TAKEUCHI","familyNameLang":"en"}],"givenNames":[{"givenName":"宏","givenNameLang":"ja"},{"givenName":"HIROSHI","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4093","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000040102123","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000040102123"},{"nameIdentifier":"40102123","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40102123"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-01-21"}],"displaytype":"detail","filename":"gifushika353_96104_2009.pdf","filesize":[{"value":"4.4 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"gifushika353_96104_2009","url":"https://asahi-u.repo.nii.ac.jp/record/5166/files/gifushika353_96104_2009.pdf"},"version_id":"fa977936-d0d7-42c5-b2e8-761b3b46b630"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"頭蓋底","subitem_subject_scheme":"Other"},{"subitem_subject":"軟骨結合","subitem_subject_scheme":"Other"},{"subitem_subject":"成長板","subitem_subject_scheme":"Other"},{"subitem_subject":"Indian hedgehog","subitem_subject_scheme":"Other"},{"subitem_subject":"Wnt","subitem_subject_scheme":"Other"},{"subitem_subject":"β-catenin","subitem_subject_scheme":"Other"},{"subitem_subject":"シグナルトランスダクション","subitem_subject_scheme":"Other"},{"subitem_subject":"成長板","subitem_subject_scheme":"Other"},{"subitem_subject":"軟骨","subitem_subject_scheme":"Other"},{"subitem_subject":"骨形成因子","subitem_subject_scheme":"Other"},{"subitem_subject":"cranial base","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"synchondrosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"growth plate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Indian hedgehog","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Wnt","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"β-catenin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Beta Catenin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hedgehog Proteins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Wnt Proteins","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"頭蓋底軟骨結合　その成長を調節する分子メカニズムと異常","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"頭蓋底軟骨結合　その成長を調節する分子メカニズムと異常"},{"subitem_title":"The Cranial Base Synchondrosis: A Function and Skeletal Diseases","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"21","path":["344"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-01-21"},"publish_date":"2017-01-21","publish_status":"0","recid":"5166","relation_version_is_last":true,"title":["頭蓋底軟骨結合　その成長を調節する分子メカニズムと異常"],"weko_creator_id":"21","weko_shared_id":-1},"updated":"2024-01-17T07:09:16.626115+00:00"}