{"created":"2023-06-23T12:15:26.400412+00:00","id":5175,"links":{},"metadata":{"_buckets":{"deposit":"238ec225-095b-41ff-a121-19639eccbdb1"},"_deposit":{"created_by":21,"id":"5175","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"5175"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00005175","sets":["46:190:344"]},"author_link":["4093","4274","4056","3405","8719","1290","8698","3993","8704","3953","4247"],"item_10002_biblio_info_77":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-02-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"198","bibliographicPageStart":"182","bibliographicVolumeNumber":"35","bibliographic_titles":[{"bibliographic_title":"岐阜歯科学会雑誌"},{"bibliographic_title":"The journal of Gifu Dental Society","bibliographic_titleLang":"en"}]}]},"item_10002_description_80":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"高齢化社会を迎えて増加の一途を辿っている閉経後性骨粗鬆症は口腔にも顎骨の吸収や歯周炎をひき起こす。本症はエストロゲン欠乏によって生じる高回転型の骨代謝性疾患であるが、その成因についてはまだほとんど知られていない。そこで今回、卵巣を摘出した骨粗鬆症モデルラット(OVX)を用いて、骨代謝の主役の骨芽細胞と破骨細胞の分化や活性化に関連している各種の発現因子の動態あるいは消長を、脛骨と下顎骨で免疫組織化学的に検索した。OVXは摘出後3ヵ月で両骨の海綿骨の消失、ハバース管およびフォルクマン管様の管の内壁の拡大、下顎骨ではこれらに加えて、骨髄腔・下歯槽神経管・歯根膜腔の開大を認めた。発現因子は無処置対照ラットと比べて発現低下したもの(bFGF、FGFR、BMP2/4、Runx2、Osterix、Wnt、LRP5、OPG)、変化のなかったもの(RANKL、RANK)および増強したもの(βcatenin)の3種類に大別できた。この結果からは、(1)骨芽細胞誘導因子とその転写因子の発現低下による骨芽細胞の分化・増殖抑制が生じること、(2)その骨芽細胞によるRANKLの発現と破骨細胞前駆細胞によるRANKの発現には影響はないが、Wntの発現抑制に始まるβcateninの増加とリン酸化亢進によるOPGの発現停止が起因する破骨細胞分化亢進が起こることが示唆された。","subitem_description_type":"Abstract"}]},"item_10002_description_81":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Postmenopuosal osteoporosis involves oral lesions such as the resorption of cancerous and cortical bone, and periodontal disease; however, the crisis mechanisms of this type of osteoporosis are not well known. In order to elucidate the mechanisms, immunohistochemical analysis was performed of the expression features of factors concerning the differentiation of osteoblasts land osteoclasts, which play an important role in bone metabolism, using model rats that had unolergone surgical removal of the ovaries. The expression pattern of factors was classified into three groups: 1) underexpression group (bFGF, FGFR, BMP2/4, Runx2, Osterix. Wnt, LRP5, OPG), 2) no change group (RANKL, RANK), 3) overexpression group (βcatenin). These findings strongly suggest that osteoblast differentiation is suppressed by under-expression of induction and transcription factors. It is also indicated that βcatenin overexpression following underexpression of Wnt and LRP5 causes non-expression of OPG, and such an expression pattern readily connects RANKL to RANK, which facilitates osteoclast differentiation.","subitem_description_type":"Other"}]},"item_10002_full_name_75":{"attribute_name":"著者別名","attribute_value_mlt":[{"affiliations":[{"affiliationNames":[{"affiliationName":"朝日大学歯学部歯科放射線学分野","lang":"ja"}],"nameIdentifiers":[]}],"familyNames":[{"familyName":"松岡","familyNameLang":"ja"},{"familyName":"MATSUOKA","familyNameLang":"en"}],"givenNames":[{"givenName":"正登","givenNameLang":"ja"},{"givenName":"MASATO","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3993","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000387366471","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000387366471"}],"names":[{"name":"松岡, 正登","nameLang":"ja"},{"name":"MATSUOKA, MASATO","nameLang":"en"}]},{"nameIdentifiers":[{"nameIdentifier":"4247","nameIdentifierScheme":"WEKO"}],"names":[{"name":"FUJISHITA, MASAMI"}]},{"nameIdentifiers":[{"nameIdentifier":"3953","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005795131","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005795131"}],"names":[{"name":"TSUKAHARA, TAKASHI"}]},{"nameIdentifiers":[{"nameIdentifier":"8704","nameIdentifierScheme":"WEKO"}],"names":[{"name":"NAKAZAWA, JUNKO"}]},{"affiliations":[{"affiliationNames":[{"affiliationName":"朝日大学歯学部","lang":"ja"}],"nameIdentifiers":[]}],"familyNames":[{"familyName":"永山","familyNameLang":"ja"},{"familyName":"NAGAYAMA","familyNameLang":"en"}],"givenNames":[{"givenName":"元彦","givenNameLang":"ja"},{"givenName":"MOTOHIKO","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1290","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000050298436","nameIdentifierScheme":"CiNii 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HIROSHI"}]}]},"item_10002_radio_89":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_radio_item":"application/pdf"}]},"item_10002_relation_85":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"110007544669","subitem_relation_type_select":"NAID"}}]},"item_10002_relation_86":{"attribute_name":"医中誌文献番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"2009169390","subitem_relation_type_select":"ICHUSHI"}}]},"item_10002_source_id_82":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-0072","subitem_source_identifier_type":"ISSN"}]},"item_10002_source_id_84":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053070","subitem_source_identifier_type":"NCID"}]},"item_10002_textarea_76":{"attribute_name":"所属","attribute_value_mlt":[{"subitem_textarea_value":"朝日大学歯学部口腔病態医療学講座歯科放射線学分野\nDepartment of Oral and Maxillofacial Radiology, Division of Oral Pathogenesis and Disease Control"},{"subitem_textarea_value":"朝日大学歯学部口腔病態医療学講座歯科放射線学分野\nDepartment of Oral and Maxillofacial Radiology, Division of Oral Pathogenesis and Disease Control"},{"subitem_textarea_value":"朝日大学歯学部総合医科学講座外科学分野\nDepartment of Orthopaedic Surgery, Division of General Medicine"},{"subitem_textarea_value":"朝日大学歯学部総合医科学講座外科学分野\nDepartment of Orthopaedic Surgery, Division of General Medicine"},{"subitem_textarea_value":"朝日大学歯学部口腔病態医療学講座口腔病理学分野\nDepartment of Oral Pathology, Division of Oral Pathogenesis and Disease Control"},{"subitem_textarea_value":"朝日大学歯学部口腔病態医療学講座口腔病理学分野\nDepartment of Oral Pathology, Division of Oral Pathogenesis and Disease Control"}]},"item_10002_version_type_95":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松岡, 正登"}],"nameIdentifiers":[{"nameIdentifier":"8719","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000254174153","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000254174153"}]},{"creatorNames":[{"creatorName":"藤下, 昌巳"}],"nameIdentifiers":[{"nameIdentifier":"4056","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000050028809","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000050028809"},{"nameIdentifier":"50028809","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50028809"}]},{"creatorNames":[{"creatorName":"塚原, 隆司"}],"nameIdentifiers":[{"nameIdentifier":"3405","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005795131","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005795131"}]},{"creatorNames":[{"creatorName":"中澤, 純子"}],"nameIdentifiers":[{"nameIdentifier":"8698","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000014650599","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000014650599"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":"朝日大学歯学部","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"永山, 元彦","creatorNameLang":"ja"},{"creatorName":"NAGAYAMA, MOTOHIKO","creatorNameLang":"en"}],"familyNames":[{"familyName":"永山","familyNameLang":"ja"},{"familyName":"NAGAYAMA","familyNameLang":"en"}],"givenNames":[{"givenName":"元彦","givenNameLang":"ja"},{"givenName":"MOTOHIKO","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1290","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000050298436","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000050298436"},{"nameIdentifier":"50298436","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50298436"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"竹内, 宏","creatorNameLang":"ja"},{"creatorName":"TAKEUCHI, HIROSHI","creatorNameLang":"en"}],"familyNames":[{"familyName":"竹内","familyNameLang":"ja"},{"familyName":"TAKEUCHI","familyNameLang":"en"}],"givenNames":[{"givenName":"宏","givenNameLang":"ja"},{"givenName":"HIROSHI","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4093","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000040102123","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000040102123"},{"nameIdentifier":"40102123","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40102123"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-01-23"}],"displaytype":"detail","filename":"gifushika353_182198_2009.pdf","filesize":[{"value":"23.8 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"gifushika353_182198_2009","url":"https://asahi-u.repo.nii.ac.jp/record/5175/files/gifushika353_182198_2009.pdf"},"version_id":"cb0d544f-1b31-49ba-9485-fade281cb67c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"閉経後性骨粗鬆症","subitem_subject_scheme":"Other"},{"subitem_subject":"卵巣摘出ラット","subitem_subject_scheme":"Other"},{"subitem_subject":"骨芽細胞分化因子","subitem_subject_scheme":"Other"},{"subitem_subject":"破骨細胞分化因子","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫組織化学","subitem_subject_scheme":"Other"},{"subitem_subject":"骨芽細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"骨粗鬆症","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞分化","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫組織化学","subitem_subject_scheme":"Other"},{"subitem_subject":"卵巣摘出術","subitem_subject_scheme":"Other"},{"subitem_subject":"Wistarラット","subitem_subject_scheme":"Other"},{"subitem_subject_scheme":"Other"},{"subitem_subject":"Postmenopuosal osteoporosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ovary removed rat","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteoblast differentiating factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteoclast differentiating factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Immunohistochemistry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Beta Catenin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Receptor Activator of Nuclear Factor-Kappa B","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Wnt Proteins","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"卵巣摘出ラットにおける骨病変および骨芽細胞と破骨細胞の分化因子の動態","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"卵巣摘出ラットにおける骨病変および骨芽細胞と破骨細胞の分化因子の動態"},{"subitem_title":"The lesion of bone and movement of osteoblast and osteoclast differentiating factors on ovari ectomized rat","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"21","path":["344"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-01-23"},"publish_date":"2017-01-23","publish_status":"0","recid":"5175","relation_version_is_last":true,"title":["卵巣摘出ラットにおける骨病変および骨芽細胞と破骨細胞の分化因子の動態"],"weko_creator_id":"21","weko_shared_id":-1},"updated":"2024-01-17T07:09:15.184825+00:00"}