{"created":"2023-06-23T12:15:27.353923+00:00","id":5197,"links":{},"metadata":{"_buckets":{"deposit":"c053a003-b8ba-4902-9b05-71bebf6a051a"},"_deposit":{"created_by":21,"id":"5197","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"5197"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00005197","sets":["46:190:345"]},"author_link":["8629","8734","8627","6806","8732","5691","8624","8731","8625","8733"],"item_10002_biblio_info_77":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-06-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographicVolumeNumber":"35","bibliographic_titles":[{"bibliographic_title":"岐阜歯科学会雑誌"},{"bibliographic_title":"The journal of Gifu Dental Society","bibliographic_titleLang":"en"}]}]},"item_10002_description_80":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ラット唾液腺における細胞質型グルタチオンペルオキシダーゼ(cGPx)とリン脂質ヒドロペルオキシドグルタチオンペルオキシダーゼ(PHGPx)の分布を検討した。三大唾液腺のうち、顎下腺と舌下腺では高いcGPx活性が認められたが、耳下腺では他の唾液腺の約30%の活性であった。cGPxは主として細胞質画分に分布した。一方、PHGPx活性は顎下腺、耳下腺、舌下腺の順に高い活性を示した。舌下腺のPHGPx活性はcGPx活性とは異なり、他の唾液腺よりかなり低かった。PHGPx活性は細胞質画分、ミトコンドリア画分、ミクロソーム画分に広く分布した。顎下腺ではこれらの画分でほぼ同程度の活性を示したが、耳下腺細胞質画分と舌下腺ミトコンドリア画分の活性は他の画分より低かった。細胞質画分とミトコンドリア画分のPHGPx活性はリン脂質種に対する特異性が低く、細胞内で生じる種々のリン脂質ヒドロペルオキシドの還元処理に好都合である。cGPxとPHGPxの腺特異的な分布は、唾液分泌能に依存する酸素消費量の違いやPHGPxアイソザイムの分布差から生じるものと考えられる。さらに、唾液腺のcGPxとPHGPxは抗酸化酵素として役割を分担しながらヒドロペルオキシドの消去を担っており、cGPxは細胞質で生じる水溶性ヒドロペルオキシドを、PHGPxは細胞内の種々の場で生じるリン脂質ヒドロペルオキシドを還元処理していることが示唆された。","subitem_description_type":"Abstract"}]},"item_10002_description_81":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Distribution of cytosolic glutathione peroxidase( cGPx)activity and phospholipid hydroperoxide glutathione peroxidase(PHGPx)was observed in rat salivary glands. Among three major glands, high cGPx activity was observed insubmandibular and sublingual glands; activity in the parotid gland was about30% that of other glands. In intracellularfractions, cGPx activity was mainly distributed in the cytosolic fraction. On the other hand, PHGPx activity was inthe following order: submandibular, parotid and sublingual glands. PHGPx activity in the sublingual gland was relativelylower than the other glands in contrast to cGPx activity. PHGPx activity was widely distributed in cytosolic, mitochondrialand microsomal fractions. Activities in parotid mitochondrial and sublingual cytosolic fractions were relativelylower than the other fractions, although those in the submandibular gland were almost the same among the threefractions. In addition, PHGPx activities in both cytosolic and mitochondrial fractions showed less preference towardthe phospholipid head-group, which is effective for the reduction of various phospholipid hydroperoxides formed incells. The gland-specific distribution of cGPx and PHGPx may be caused by differences in oxygen consumption dependingon saliva-secretory ability and distribution of PHGPx isozymes. In addition, it is suggested that cGPx andPHGPx in salivary glands share a role in the reduction of hydroperoxide as an antioxidant; cGPx reduces hydrophilichydroperoxide in cytosol but PHGPx reduces phospholipid hydroperoxide in various compartments of cells.","subitem_description_type":"Other"}]},"item_10002_full_name_75":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"6806","nameIdentifierScheme":"WEKO"}],"names":[{"name":"YASHIRO, KOJI"}]},{"nameIdentifiers":[{"nameIdentifier":"8733","nameIdentifierScheme":"WEKO"}],"names":[{"name":"KITAMURA, KEISHI"}]},{"nameIdentifiers":[{"nameIdentifier":"8629","nameIdentifierScheme":"WEKO"}],"names":[{"name":"KAMIYA, MASAKO"}]},{"nameIdentifiers":[{"nameIdentifier":"5691","nameIdentifierScheme":"WEKO"}],"names":[{"name":"KAMEYAMA, YASUNAGA"}]},{"nameIdentifiers":[{"nameIdentifier":"8734","nameIdentifierScheme":"WEKO"}],"names":[{"name":"FUJITA, ATSUSHI"}]}]},"item_10002_radio_89":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_radio_item":"application/pdf"}]},"item_10002_relation_85":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110007470455","subitem_relation_type_select":"NAID"}}]},"item_10002_relation_86":{"attribute_name":"医中誌文献番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2008300974","subitem_relation_type_select":"ICHUSHI"}}]},"item_10002_source_id_82":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-0072","subitem_source_identifier_type":"ISSN"}]},"item_10002_source_id_84":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053070","subitem_source_identifier_type":"NCID"}]},"item_10002_textarea_76":{"attribute_name":"所属","attribute_value_mlt":[{"subitem_textarea_value":"朝日大学歯学部口腔構造機能発育学講座口腔生化学分野\nDepartment of Oral Biochemistry, Division of Oral Structure, Function and Development Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部口腔構造機能発育学講座口腔生化学分野\nDepartment of Oral Biochemistry, Division of Oral Structure, Function and Development Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部口腔構造機能発育学講座口腔生化学分野\nDepartment of Oral Biochemistry, Division of Oral Structure, Function and Development Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部口腔構造機能発育学講座口腔生化学分野\nDepartment of Oral Biochemistry, Division of Oral Structure, Function and Development Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部口腔構造機能発育学講座口腔生化学分野\nDepartment of Oral Biochemistry, Division of Oral Structure, Function and Development Asahi University School of Dentistry"}]},"item_10002_version_type_95":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"八代, 耕児"}],"nameIdentifiers":[{"nameIdentifier":"8625","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000050182316","nameIdentifierScheme":"NRID","nameIdentifierURI":" https://rns.nii.ac.jp/d/nr/1000050182316"}]},{"creatorNames":[{"creatorName":"北村, 圭司"}],"nameIdentifiers":[{"nameIdentifier":"8731","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000004730873","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000004730873"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"33703","affiliationNameIdentifierScheme":"kakenhi","affiliationNameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=33703"}],"affiliationNames":[{"affiliationName":"朝日大学","affiliationNameLang":"ja"},{"affiliationName":"Chemistry Laboratory, Department of Management and Information studies, Asahi University School of Business Administration","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"神谷, 真子","creatorNameLang":"ja"},{"creatorName":"KAMIYA, MASAKO","creatorNameLang":"en"}],"familyNames":[{"familyName":"神谷","familyNameLang":"ja"},{"familyName":"KAMIYA","familyNameLang":"en"}],"givenNames":[{"givenName":"真子","givenNameLang":"ja"},{"givenName":"MASAKO","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8627","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000080181907","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000080181907"},{"nameIdentifier":"80181907","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80181907"}]},{"creatorNames":[{"creatorName":"亀山, 泰永"}],"nameIdentifiers":[{"nameIdentifier":"8624","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000050161245","nameIdentifierScheme":"NRID","nameIdentifierURI":" https://rns.nii.ac.jp/d/nr/1000050161245"}]},{"creatorNames":[{"creatorName":"藤田, 厚"}],"nameIdentifiers":[{"nameIdentifier":"8732","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000060067098","nameIdentifierScheme":"NRID","nameIdentifierURI":" https://rns.nii.ac.jp/d/nr/1000060067098"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-01-25"}],"displaytype":"detail","filename":"gifushika351_16_2008.pdf","filesize":[{"value":"197.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"gifushika351_16_2008","url":"https://asahi-u.repo.nii.ac.jp/record/5197/files/gifushika351_16_2008.pdf"},"version_id":"78678881-0455-4324-a778-4c878f85cb87"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ヒドロペルオキシド","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞質型グルタチオンペルオキシダーゼ","subitem_subject_scheme":"Other"},{"subitem_subject":"リン脂質ヒドロペルオキシドグルタチオンペルオキシダーゼ","subitem_subject_scheme":"Other"},{"subitem_subject":"唾液腺","subitem_subject_scheme":"Other"},{"subitem_subject":"過酸化水素","subitem_subject_scheme":"Other"},{"subitem_subject":"顎下腺","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞質","subitem_subject_scheme":"Other"},{"subitem_subject":"耳下腺","subitem_subject_scheme":"Other"},{"subitem_subject":"舌下腺","subitem_subject_scheme":"Other"},{"subitem_subject":"Wistarラット","subitem_subject_scheme":"Other"},{"subitem_subject":"Hydroperoxide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cytosolic glutathione peroxidase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Phospholipid hydroperoxide glutathione peroxidase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Salivary gland","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ラット唾液腺の細胞質型グルタチオンペルオキシダーゼ活性およびリン脂質ヒドロペルオキシドグルタチオンペルオキシダーゼ活性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ラット唾液腺の細胞質型グルタチオンペルオキシダーゼ活性およびリン脂質ヒドロペルオキシドグルタチオンペルオキシダーゼ活性"},{"subitem_title":"Activities of Cytosolic Glutathione Peroxidase and Phospholipid Hydroperoxide Glutathione Peroxidase in Rat Salivary Glands","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"21","path":["345"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-01-25"},"publish_date":"2017-01-25","publish_status":"0","recid":"5197","relation_version_is_last":true,"title":["ラット唾液腺の細胞質型グルタチオンペルオキシダーゼ活性およびリン脂質ヒドロペルオキシドグルタチオンペルオキシダーゼ活性"],"weko_creator_id":"21","weko_shared_id":-1},"updated":"2024-05-02T09:27:34.692722+00:00"}