{"created":"2023-06-23T12:15:28.806989+00:00","id":5231,"links":{},"metadata":{"_buckets":{"deposit":"14fa6eab-2edf-4d6c-8965-155064d7f59a"},"_deposit":{"created_by":21,"id":"5231","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"5231"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00005231","sets":["46:190:351"]},"author_link":["8629","8734","8627","6806","8732","5691","8624","8625"],"item_10002_biblio_info_77":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-02-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"109","bibliographicPageStart":"105","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"岐阜歯科学会雑誌"},{"bibliographic_title":"The Journal of Gifu Dental Society","bibliographic_titleLang":"en"}]}]},"item_10002_description_80":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ラット顎下腺および耳下腺ミクロソームの1-アシル-sn-グリセロ-3-ホスホコリンアシルトランスフェラーゼの基質特異性を検討した。顎下腺の酵素は、5,8,11,14,17-エイコサペンタエノイル-CoAに対して一番活性が高く、次いで11,14,17-エイコサトリエノイル-、アラキドノイル-、オレオイル-CoAの順であった。一方、飽和アシル-CoAに対する基質特異性は不飽和アシル-CoAのそれより低かった。耳下腺では、5,8,11,14,17-エイコサペンタエノイル-CoAに対して一番活性が高く、次いで11,14,17-エイコサトリエノイル-、γ-リノレノイル-、アラキドノイル-CoAの順であった。顎下腺ミクロソームの1-アシル-sn-グリセロ-3-ホスホコリンアシルトランスフェラーゼ活性は耳下腺のそれより2-5倍高かった。この酵素は、トランス型および分枝鎖型アシル-CoAに対しても高い活性を示した。顎下腺、耳下腺における酵素の比活性の解析から、本酵素は炭化水素鎖長:18以上、二重結合の数:3-5個のアシル-CoAに対して高活性を示した。これらの結果は、唾液腺の1-アシル-sn-グリセロ-3-ホスホコリンアシルトランスフェラーゼがエイコサノイドに関連したアシル-CoAを良い基質にすることが示唆された。このことは、ミクロソームの再アシル化系酵素がホスファチジルコリン内にエイコサノイド前駆物質を蓄積するのに重要であると考えられる。","subitem_description_type":"Abstract"}]},"item_10002_description_81":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The substrate specificities of microsomal 1-acyl-sn-glycero-3-phosphocholine acyltransferase were observed in the rat submandibular and parotid glands. The most preferable substrate in the submandibular gland was 5,8,11,14,17-eicosapentaenoyl-CoA followed by 11,14,17-eicosatrienoyl-, arachidonoyl- and oleoyl-CoAs. However, the specificity for saturated acyl-CoAs was lower than those for the polyunsaturated acyl-CoAs. In the parotid gland, the highest enzyme activity was also for 5,8,11,14,17-eicosapentaenoyl-CoA followed by 11,14,17-eicosatrienoyl-,γ-linolenoyl- and arachidonoyl-CoAs. These specificities also closely resemble those of the liver. When1-acyl-snglycero-3-phosphocholine acyltransferase activity is compared among the salivary glands and liver, activity in the submandibular gland was 2-5 times and about two times higher than those in the parotid gland and liver, respectively. 1-Acyl-sn-glycero-3-phosphocholine acyltransferase also utilized acyl-CoAs having trans-unsaturated such as elaidoyl- and linoelaidoyl-CoAs or branched chain acyl-CoA like 13-methyltetradecanoyl-CoA as substrates. Furthermore,the activities of trans-unsaturated acyl-CoAs were very similar to those of cis-unsaturated acyl-CoAs. However, it is still not clear whether the reacylation enzyme protein recognizes the cis and trans configurations. From the analysis of relative activities, 1-acyl-sn-glycero-3-phosphocholine acyltransferase from both salivary glands preferred a substrate with an acyl chain length more than 18 carbon atoms with more than 3-5 double bonds in the acyl chain. These findings suggest that eicosanoid-related acyl-CoAs are good substrate for 1-acyl-sn-glycero-3-phosphocholine acyltransferase in salivary glands. Thus, the microsomal reacylation enzyme may play a role in the storage of eicosanoid precursors for metabolism into phosphatidylcholine.","subitem_description_type":"Other"}]},"item_10002_full_name_75":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"5691","nameIdentifierScheme":"WEKO"}],"names":[{"name":"KAMEYAMA, YASUNAGA"}]},{"nameIdentifiers":[{"nameIdentifier":"8629","nameIdentifierScheme":"WEKO"}],"names":[{"name":"KAMIYA, MASAKO"}]},{"nameIdentifiers":[{"nameIdentifier":"6806","nameIdentifierScheme":"WEKO"}],"names":[{"name":"YASHIRO, KOJI"}]},{"nameIdentifiers":[{"nameIdentifier":"8734","nameIdentifierScheme":"WEKO"}],"names":[{"name":"FUJITA, ATSUSHI"}]}]},"item_10002_radio_89":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_radio_item":"application/pdf"}]},"item_10002_relation_85":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110007405493","subitem_relation_type_select":"NAID"}}]},"item_10002_relation_86":{"attribute_name":"医中誌文献番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2008166298","subitem_relation_type_select":"ICHUSHI"}}]},"item_10002_source_id_82":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-0072","subitem_source_identifier_type":"ISSN"}]},"item_10002_source_id_84":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053070","subitem_source_identifier_type":"NCID"}]},"item_10002_textarea_76":{"attribute_name":"所属","attribute_value_mlt":[{"subitem_textarea_value":"朝日大学歯学部口腔構造機能発育学講座口腔生化学分野\nDepartment of Oral Biochemistry, Division of Oral Structure, Function and Development, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部口腔構造機能発育学講座口腔生化学分野\nDepartment of Oral Biochemistry, Division of Oral Structure, Function and Development, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部口腔構造機能発育学講座口腔生化学分野\nDepartment of Oral Biochemistry, Division of Oral Structure, Function and Development, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学歯学部口腔構造機能発育学講座口腔生化学分野\nDepartment of Oral Biochemistry, Division of Oral Structure, Function and Development, Asahi University School of Dentistry"}]},"item_10002_version_type_95":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"亀山, 泰永"}],"nameIdentifiers":[{"nameIdentifier":"8624","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000050161245","nameIdentifierScheme":"NRID","nameIdentifierURI":" https://rns.nii.ac.jp/d/nr/1000050161245"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"33703","affiliationNameIdentifierScheme":"kakenhi","affiliationNameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=33703"}],"affiliationNames":[{"affiliationName":"朝日大学","affiliationNameLang":"ja"},{"affiliationName":"Chemistry Laboratory, Department of Management and Information studies, Asahi University School of Business Administration","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"神谷, 真子","creatorNameLang":"ja"},{"creatorName":"KAMIYA, MASAKO","creatorNameLang":"en"}],"familyNames":[{"familyName":"神谷","familyNameLang":"ja"},{"familyName":"KAMIYA","familyNameLang":"en"}],"givenNames":[{"givenName":"真子","givenNameLang":"ja"},{"givenName":"MASAKO","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8627","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000080181907","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000080181907"},{"nameIdentifier":"80181907","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80181907"}]},{"creatorNames":[{"creatorName":"八代, 耕児"}],"nameIdentifiers":[{"nameIdentifier":"8625","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000050182316","nameIdentifierScheme":"NRID","nameIdentifierURI":" https://rns.nii.ac.jp/d/nr/1000050182316"}]},{"creatorNames":[{"creatorName":"藤田, 厚"}],"nameIdentifiers":[{"nameIdentifier":"8732","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000060067098","nameIdentifierScheme":"NRID","nameIdentifierURI":" https://rns.nii.ac.jp/d/nr/1000060067098"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-10"}],"displaytype":"detail","filename":"gifushika343_105109_2008.pdf","filesize":[{"value":"528.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"gifushika343_105109_2008","url":"https://asahi-u.repo.nii.ac.jp/record/5231/files/gifushika343_105109_2008.pdf"},"version_id":"99632e5e-1741-4f24-8e2f-a57e40ece442"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"1-アシル-sn-グリセロ-3-ホスホコリンアシルトランスフェラーゼ","subitem_subject_scheme":"Other"},{"subitem_subject":"アシル-CoA基質特異性","subitem_subject_scheme":"Other"},{"subitem_subject":"ホスファチジルコリン","subitem_subject_scheme":"Other"},{"subitem_subject":"唾液腺","subitem_subject_scheme":"Other"},{"subitem_subject":"顎下腺","subitem_subject_scheme":"Other"},{"subitem_subject":"基質特異性","subitem_subject_scheme":"Other"},{"subitem_subject":"耳下腺","subitem_subject_scheme":"Other"},{"subitem_subject":"不飽和脂肪酸","subitem_subject_scheme":"Other"},{"subitem_subject":"ミクロソーム","subitem_subject_scheme":"Other"},{"subitem_subject":"Wistarラット","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット","subitem_subject_scheme":"Other"},{"subitem_subject":"1-acyｌ-sn-glycero-3-phosphocholine acyltransferase activity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Acyl Coenzyme A","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"1-Acylglycerophosphocholine O-Acyltransferase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Phosphatidylcholines","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"salivary glands","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin 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