{"created":"2023-06-23T12:15:30.591899+00:00","id":5264,"links":{},"metadata":{"_buckets":{"deposit":"8803275b-4657-4095-ade8-5f716785530e"},"_deposit":{"created_by":21,"id":"5264","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"5264"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00005264","sets":["46:190:353"]},"author_link":["8629","8734","8627","6806","8732","5691","8624","8731","8625","8733"],"item_10002_biblio_info_77":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-06-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"岐阜歯科学会雑誌"},{"bibliographic_title":"The journal of Gifu Dental Society","bibliographic_titleLang":"en"}]}]},"item_10002_description_80":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ホスファチジルコリンは、生体膜リン脂質の主要構成成分であり、エイコサノイド前駆体の多価不飽和脂肪酸の貯蔵部位である。その脂肪酸導入にはリン脂質再アシル化系酵素の一つである1-アシル-sn-グリセロール-3-ホスホコリンアシルトランスフェラーゼが関与する。そこで、ラット唾液腺の成長に伴う本酵素の活性変化について検討した。ラット顎下腺、耳下腺の湿重量は、3から9週齢に成長するにしたがってそれぞれ3および2倍に増加した。3週齢の酵素の比活性は、肝>顎下腺≧耳下腺の順であり、アシル-CoAに対する基質特異性は3組織間でほとんど変わらなかった。しかし、3週齢から10週齢に成長した顎下腺では、アシル-CoAに対する基質特異性、Km値は変化することなく、酵素活性が4～7倍に上昇した。この変化は耳下腺、肝では観察されなかった。これらの結果は、顎下腺の生後成熟過程に多価不飽和脂肪酸導入酵素が特異的に寄与している可能性が示唆された。","subitem_description_type":"Abstract"}]},"item_10002_description_81":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Among the many steps of enzyme reaction for the biosynthesis of phosphatidylcholine, it has been shown that the specific activities of these enzymes are altered during cell growth; therefore, we observed the effects of postnatal growth on a reacylation enzyme,1-acyl-sn-glycerol-3-phosphocholine acyltransferase, which functions to enrich polyunsaturated fatty acid in phosphatidylcholine in rat salivary glands. The wet weights were three-and two-times increased duringgrowthfrom3 to9 weeks old in rat submandibular and parotid glands, respectively. In microsomes from3week-old rat submandibular and parotid glands, and liver,1-acyl-sn-glycerol-3-phosphocholine acyltransferase activities were higher in the order, liver>submandibular≧ parotid glands. The specificities for acyl-CoAs were very similar; however, in10-week-old rats, the activity from submandibular microsomes was4-to7-fold higher than in3week-old rats. In this enhancement of specific activity, Km values for arachidonoyl-CoA　( 20 : 4-CoA ) did not change; on the contrary, specific activities of this enzyme in the parotid gland and liver were hardly changed during growth. These results suggest that the tissue-specific enhancement of1-acyl-sn-glycerol-3-phosphocholine acyltransferase activity may occur due to the induction of its protein, which may play a specific role in the growth of the submandibular gland.","subitem_description_type":"Other"}]},"item_10002_full_name_75":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"5691","nameIdentifierScheme":"WEKO"}],"names":[{"name":"KAMEYAMA, YASUNAGA"}]},{"nameIdentifiers":[{"nameIdentifier":"8733","nameIdentifierScheme":"WEKO"}],"names":[{"name":"KITAMURA, KEISHI"}]},{"nameIdentifiers":[{"nameIdentifier":"6806","nameIdentifierScheme":"WEKO"}],"names":[{"name":"YASHIRO, KOJI"}]},{"nameIdentifiers":[{"nameIdentifier":"8629","nameIdentifierScheme":"WEKO"}],"names":[{"name":"KAMIYA, MASAKO"}]},{"nameIdentifiers":[{"nameIdentifier":"8734","nameIdentifierScheme":"WEKO"}],"names":[{"name":"FUJITA, ATSUSHI"}]}]},"item_10002_radio_89":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_radio_item":"application/pdf"}]},"item_10002_relation_85":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110006987551","subitem_relation_type_select":"NAID"}}]},"item_10002_relation_86":{"attribute_name":"医中誌文献番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2008051172","subitem_relation_type_select":"ICHUSHI"}}]},"item_10002_source_id_82":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-0072","subitem_source_identifier_type":"ISSN"}]},"item_10002_source_id_84":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053070","subitem_source_identifier_type":"NCID"}]},"item_10002_textarea_76":{"attribute_name":"所属","attribute_value_mlt":[{"subitem_textarea_value":"Department of Oral Biochemistry, Division of Oral Structure, Function and Development Asahi University School of Dentistry"},{"subitem_textarea_value":"Department of Oral Biochemistry, Division of Oral Structure, Function and Development Asahi University School of Dentistry"},{"subitem_textarea_value":"Department of Oral Biochemistry, Division of Oral Structure, Function and Development Asahi University School of Dentistry"},{"subitem_textarea_value":"Department of Oral Biochemistry, Division of Oral Structure, Function and Development Asahi University School of Dentistry"},{"subitem_textarea_value":"Department of Oral Biochemistry, Division of Oral Structure, Function and Development Asahi University School of Dentistry"}]},"item_10002_version_type_95":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"亀山, 泰永"}],"nameIdentifiers":[{"nameIdentifier":"8624","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000050161245","nameIdentifierScheme":"NRID","nameIdentifierURI":" https://rns.nii.ac.jp/d/nr/1000050161245"}]},{"creatorNames":[{"creatorName":"北村, 圭司"}],"nameIdentifiers":[{"nameIdentifier":"8731","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000004730873","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000004730873"}]},{"creatorNames":[{"creatorName":"八代, 耕児"}],"nameIdentifiers":[{"nameIdentifier":"8625","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000050182316","nameIdentifierScheme":"NRID","nameIdentifierURI":" https://rns.nii.ac.jp/d/nr/1000050182316"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"33703","affiliationNameIdentifierScheme":"kakenhi","affiliationNameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=33703"}],"affiliationNames":[{"affiliationName":"朝日大学","affiliationNameLang":"ja"},{"affiliationName":"Chemistry Laboratory, Department of Management and Information studies, Asahi University School of Business Administration","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"神谷, 真子","creatorNameLang":"ja"},{"creatorName":"KAMIYA, MASAKO","creatorNameLang":"en"}],"familyNames":[{"familyName":"神谷","familyNameLang":"ja"},{"familyName":"KAMIYA","familyNameLang":"en"}],"givenNames":[{"givenName":"真子","givenNameLang":"ja"},{"givenName":"MASAKO","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8627","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000080181907","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000080181907"},{"nameIdentifier":"80181907","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80181907"}]},{"creatorNames":[{"creatorName":"藤田, 厚"}],"nameIdentifiers":[{"nameIdentifier":"8732","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000060067098","nameIdentifierScheme":"NRID","nameIdentifierURI":" https://rns.nii.ac.jp/d/nr/1000060067098"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-20"}],"displaytype":"detail","filename":"gifushika341_14_2007.pdf","filesize":[{"value":"119.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"gifushika341_14_2007","url":"https://asahi-u.repo.nii.ac.jp/record/5264/files/gifushika341_14_2007.pdf"},"version_id":"69bacb49-d446-4127-8a70-4f96327ba186"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"1-アシル-sn-グリセロール-3-ホスホコリンアシルトランスフェラーゼ","subitem_subject_scheme":"Other"},{"subitem_subject":"アシル-CoA基質特異性","subitem_subject_scheme":"Other"},{"subitem_subject":"ホスファチジルコリン","subitem_subject_scheme":"Other"},{"subitem_subject":"唾液腺","subitem_subject_scheme":"Other"},{"subitem_subject":"顎下腺","subitem_subject_scheme":"Other"},{"subitem_subject":"ミクロソーム","subitem_subject_scheme":"Other"},{"subitem_subject":"Sprague-Dawleyラット","subitem_subject_scheme":"Other"},{"subitem_subject":"1-acyl-sn-glycerol-3-phosphocholine acyltransferase activity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"acyl-CoA specificity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"phosphatidylcholine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"salivary gland","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Acyl Coenzyme A","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Phosphatidylcholines","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sprague-Dawleyラット","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"1-Acylglycerol-3-Phosphate O-Acyltransferase","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ラット顎下腺ミクロソームのアシル-CoA　1-アシル-sn-グリセロール-3-ホスホコリンアシルトランスフェラーゼの成長に伴う活性上昇","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ラット顎下腺ミクロソームのアシル-CoA　1-アシル-sn-グリセロール-3-ホスホコリンアシルトランスフェラーゼの成長に伴う活性上昇"},{"subitem_title":"Enhancement of Acyl-CoA:l-Acyl-sn-glycerol-3-phosphocholine Acyltransferase Activity in the Microsomes from Rat Submandibular Gland during the Growth","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"21","path":["353"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-02-20"},"publish_date":"2017-02-20","publish_status":"0","recid":"5264","relation_version_is_last":true,"title":["ラット顎下腺ミクロソームのアシル-CoA　1-アシル-sn-グリセロール-3-ホスホコリンアシルトランスフェラーゼの成長に伴う活性上昇"],"weko_creator_id":"21","weko_shared_id":-1},"updated":"2024-05-02T09:27:36.004848+00:00"}