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Differences in vertebral, tibial, and iliac cancellous bone metabolism in ovariectomized rats
https://asahi-u.repo.nii.ac.jp/records/6114
https://asahi-u.repo.nii.ac.jp/records/61147319b8fe-5913-4dd7-a697-eb5cb1ecb75c
| Item type | 朝日大学 教育・研究業績(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-11 | |||||
| タイトル | ||||||
| タイトル | Differences in vertebral, tibial, and iliac cancellous bone metabolism in ovariectomized rats | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||
| 資源タイプ | other | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 業績分類 | ||||||
| 値 | 学術雑誌論文 | |||||
| 教員氏名 |
江尻, 貞一
× 江尻, 貞一 |
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| 発行、発表雑誌等、又は発表学会等の名称 | ||||||
| 値 | J Bone Miner Metab | |||||
| 巻 | ||||||
| 値 | DOI 10.1007/s00774-015-0678-y | |||||
| 掲載ページ | ||||||
| 値 | DOI 10.1007/s00774-015-0678-y | |||||
| 単著、共著の別 | ||||||
| 値 | 共著 | |||||
| 発行又は発表の年月 | ||||||
| 日付 | 2015-08 | |||||
| ISBN | ||||||
| 値 | DOI 10.1007/s00774-015-0678-y | |||||
| ISSN | ||||||
| 値 | DOI 10.1007/s00774-015-0678-y | |||||
| 概要 | ||||||
| 値 | （共著）Takakura A, Takao-Kawabata R, Isogai Y, Kajiwara M, Murayama H, Ejiri S, Ishizuya T. Bone histomorphometry is usually performed on the iliac bone in humans and the tibia or vertebrae in rats. Bone metabolism differences among skeletal sites may be problematic when translating experimental results from rats to humans, but data on such differences in rats are lacking. Therefore, we examined the differences in bone structure and metabolism among skeletal sites using the lumbar vertebra (LV), tibia, and iliac bone obtained from ovariectomized or sham-operated rats preoperatively and at various times from 3 days to 26 weeks postoperatively. The trabeculae were thicker in the LV, where bone metabolism was less active than at other sites, and numerous fine trabeculae were observed in the tibia, where bone metabolism was more active. The iliac bone structure and metabolism were intermediate between those of the tibia and LV. Ovariectomy induced lower bone volume and higher bone metabolism in all skeletal sites, but the changes were greatest and occurred earliest in the tibia, followed by the iliac bone and then LV. Ovariectomy caused changes in bone metabolic markers, which occurred earlier than those in bone tissue. Activation frequency (Ac.f) increased after ovariectomy. At week 26 in ovariectomized rats, Ac.f was highest in the tibia (3.13 N/year) but similar between iliac bone (0.87 N/year) and LV (1.39 N/year). Ac.f is reportedly 0.3–0.4 N/year in the iliac bone of postmenopausal women, suggesting that bone turnover in rats is several times higher than in humans. The reference values reported here are useful for translating experimental results from rats to humans. |
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