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Association between periodontitis and prognosis of pancreatobiliary tract cancer: A pilot study
https://asahi-u.repo.nii.ac.jp/records/7745
https://asahi-u.repo.nii.ac.jp/records/7745ef3733be-d12c-4bcf-b8af-d7fbd3becc1b
| Item type | 朝日大学 教育・研究業績(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-13 | |||||
| タイトル | ||||||
| タイトル | Association between periodontitis and prognosis of pancreatobiliary tract cancer: A pilot study | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||
| 資源タイプ | other | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 業績分類 | ||||||
| 値 | 学術雑誌論文 | |||||
| 教員氏名 |
友藤, 孝明
× 友藤, 孝明 |
|||||
| 発行、発表雑誌等、又は発表学会等の名称 | ||||||
| 値 | Mol Clin Oncol | |||||
| 巻 | ||||||
| 値 | 6 | |||||
| 号 | ||||||
| 値 | 5 | |||||
| 掲載ページ | ||||||
| 値 | 683-687 | |||||
| 単著、共著の別 | ||||||
| 値 | 共著 | |||||
| 発行又は発表の年月 | ||||||
| 日付 | 2017-04-10 | |||||
| ISSN | ||||||
| 値 | 2049-9469 | |||||
| 概要 | ||||||
| 値 | Several studies have indicated that periodontitis is a risk factor for cancer. However, the association between periodontitis and the prognosis of pancreatobiliary tract cancer remains unclear. The aim of this pilot study was to investigate the association between periodontitis and prognosis of pancreatobiliary tract cancer. A total of 22 patients diagnosed with pancreatobiliary tract cancer were analyzed. Oral health status, including severity of periodontitis, general health status and biochemical serum markers were evaluated. The Kaplan‑Meier method and Cox proportional hazards model were used to assess factors affecting the prognosis of pancreatobiliary tract cancer. The Kaplan-Meier analysis demonstrated that low body mass index, high concentration of serum C‑reactive protein (CRP) and severe periodontitis were significant prognostic factors for survival rate. The Cox proportional hazards model revealed that serum carbohydrate antigen 19‑9 concentration [hazard ratio (HR)=1.002; 95% confidence interval (CI): 1.000‑1.004] and serum CRP concentration (HR=2.57; 95% CI: 1.15‑5.74) were significantly associated with the prognosis of pancreatobiliary tract cancer. In addition, cancer patients with severe periodontitis had higher serum CRP concentrations compared with those without severe periodontitis. Therefore, severe periodontitis indirectly affected the prognosis of pancreatobiliary tract cancer through promoting systemic inflammation. | |||||
