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Detection Of Gut-expressed Jejunal Taste Signaling Elements In Patients With Obesity
https://asahi-u.repo.nii.ac.jp/records/8576
https://asahi-u.repo.nii.ac.jp/records/8576957772a5-ef48-45b2-95e4-1022ea1af064
| Item type | 朝日大学 教育・研究業績(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-01-10 | |||||
| タイトル | ||||||
| タイトル | Detection Of Gut-expressed Jejunal Taste Signaling Elements In Patients With Obesity | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||
| 資源タイプ | other | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 業績分類 | ||||||
| 値 | 学会発表 | |||||
| 教員氏名 |
安尾, 敏明
× 安尾, 敏明 |
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| 発行、発表雑誌等、又は発表学会等の名称 | ||||||
| 値 | Obesity Week 2017 | |||||
| 単著、共著の別 | ||||||
| 値 | 共同発表 | |||||
| 発行又は発表の年月 | ||||||
| 日付 | 2017-10-29 | |||||
| 概要 | ||||||
| 値 | Background: There has been a dramatic increase in obesity worldwide, making obesity a major health problem. It is generally accepted that obesity is associated with low-grade systemic inflammation. Previous studies have shown that taste signaling proteins such as G protein gustducin (GNAT3) and phospholipase C, beta 2 (PLCb2) are expressed in the human gut, especially, in intestinal tuft cells, which play a critical role in innate epithelial immunity against parasitic infection. Additionally, it has been shown that taste signaling controls metabolism, including the regulation of body weight and adiposity via intestinal tuft cells and taste cells in mice. This study aimed to determine if taste signaling is altered in patients with extreme obesity. Methods: The mRNA expression level of PLCb2 and GNAT3 in the proximal discarded jejunum obtained from patients with obesity who underwent bariatric surgery (BMI under 40, 40-49, and 50-59) and was examined using polymerase chain reaction (PCR). After reverse transcript PCR, the intensity of the amplified bands was measured by using imageJ and GAPDH was used as the internal control. Preliminary results of the initial 12 patients were analyzed including with BMI<40, 3 with BMI 40-49, and 5 with BMI 50-59. Results: Our preliminary data suggest that the intensity of the amplified PLCb2 product from BMI 50-59 patients was lower than those with BMI<50. The intensity of GNAT3 bands was similar across the three BMI groups.Conclusions: Our data suggest that taste signaling elements may be altered in patients with extreme obesity, and dysregulation of taste signaling may contribute to obesity. |
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