@article{oai:asahi-u.repo.nii.ac.jp:00008833,
 author = {TAKEUCHI, AYA and 永山, 元彦 and NAGAYAMA, MOTOHIKO and EHARA, MICHIKO and TANUMA, JUN-ICHI and KITAI, NORIYUKI and 竹内, 綾 and 永山, 元彦 and NAGAYAMA, MOTOHIKO and 江原, 道子 and 田沼, 順一 and 北井, 則行 and KITAI, NORIYUKI},
 issue = {3},
 journal = {Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology},
 month = {Mar},
 note = {application/pdf, Objective
The cranial base synchondrsoses are essential for antero-posterior elongation. We created a cartilage calcification insufficient (CCI) rat showing spontaneous skeletal dwarfism associated with abnormal endochondral ossification. We focused on their morphological characteristics of the cranial base synchondrosis and compared to the normal SD rat.
Study Design
After 2 to 4 weeks of birth, rats were sacrificed and extracted total RNA from knee joints, or fixed heads in 10% buffered formalin. Samples were analyzed by real time PCR or micro CT and histological procedures.
Results
The CCI rat showed abnormal synchondrosis including longitudinally wider length of the intra-sphenoidal synchondrosis (IS) and spheno-occipital synchondrosis (SO) compared to the normal SD rat. Histologically, the resting and proliferating zone chondrocytes of both synchondrosis cartilage tissue in CCI rats were wide and disorganized.
Conclusions
The data demonstrate that CCI rats show cranial base synchodrosis disorder associated with the arrest or delay of the endochondral ossification.},
 pages = {e141--e141},
 title = {Abnormal Cranial Base Synchondrosis Development and Growth in Cartilage Calcification Insufficient Rat.},
 volume = {119},
 year = {2015}
}