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Age-related changes of CD4+ T cell migration and cytokine expression in germ-free and SPF mice periodontium.
https://asahi-u.repo.nii.ac.jp/records/9436
https://asahi-u.repo.nii.ac.jp/records/943600a477b2-1001-4c2b-8818-aa314c7122a0
| Item type | 朝日大学 教育・研究業績(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-10-22 | |||||
| タイトル | ||||||
| タイトル | Age-related changes of CD4+ T cell migration and cytokine expression in germ-free and SPF mice periodontium. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||
| 資源タイプ | other | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 業績分類 | ||||||
| 値 | 学術雑誌論文 | |||||
| 教員氏名 |
友藤, 孝明
× 友藤, 孝明 |
|||||
| 発行、発表雑誌等、又は発表学会等の名称 | ||||||
| 値 | Arch Oral Biol | |||||
| 巻 | ||||||
| 値 | 87 | |||||
| 号 | ||||||
| 値 | 5 | |||||
| 掲載ページ | ||||||
| 値 | 72-78 | |||||
| 単著、共著の別 | ||||||
| 値 | 共著 | |||||
| 概要 | ||||||
| 値 | Increasing age is a potential risk factor for periodontal tissue breakdown, which may be affected by commensal flora. The aim of this study evaluated age-related changes in CD4+ T cells, C-C chemokine ligand 5 (CCL5), interleukin (IL)-17A, and receptor activator of nuclear factor-kappa B ligand (RANKL) expression using germ-free (GF) and conventionally reared (SPF) mice. SPF mice, but not GF mice, showed an age-related increase in alveolar bone loss (P < 0.01). SPF mice at 22 weeks of age increased expression of CD4+ T cells, CCL5, IL-17A, and RANKL compared to those at 8 weeks of age in connective tissue and alveolar bone surface (P < 0.01). Furthermore, there was increased CD4+ T cells, which were co-expressed with IL-17A and RANKL in SPF mice at 22 weeks of age. On the other hand, the GF mice did not show any significant differences in CD4+ T cells, CCL5, IL-17A and RANKL expression between the two age groups. | |||||
