{"created":"2023-06-23T12:18:59.091653+00:00","id":9790,"links":{},"metadata":{"_buckets":{"deposit":"5dde630b-d084-4ed9-bb1e-f6ff668c4219"},"_deposit":{"created_by":21,"id":"9790","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"9790"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00009790","sets":["46:348:384"]},"author_link":["3930","3933","3931","4171","3934","4172"],"item_10002_biblio_info_77":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"7","bibliographicPageStart":"1","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"岐阜歯科学会雑誌"},{"bibliographic_title":"The Journal of Gifu Dental Society","bibliographic_titleLang":"en"}]}]},"item_10002_description_80":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"オートファジーは酵母から哺乳動物まで保存された細胞内分解機構であり、細胞内浄化、栄養素のリサイクルと恒常性の維持を担う。現在までに、老化がオートファジーの活性低下を引き起こすこと、一方で、オートファジーが抑制されると老化との関連性の高い退行性変化や疾患が引き起こされることが明らかにされている。さらに、薬理学的特性あるいは遺伝学的特性に基づいた延命治療はオートファジーを活性化すること、一方で、オートファジーが抑制されると延命効果が妨げられることが様々なモデル動物において分かっている。この総説では、オートファジーと老化の関連性に関する近年の知見ついて報告する。\nAutophagy is an intracellular degradation system conserved from yeast to mammals, which is responsible for intracellular clearance, recycling of nutrients, and maintenance of homeostasis. Aging is often associated with a reduced autophagic potential, whereas the inhibition of autophagy induces degenerative changes in mammalian tissues that resemble those associated with aging. Pharmacological or genetic manipulations that increase the life span of model organisms often stimulate autophagy, and its inhibition compromises the longevity-promoting effects of these treatments. In this review, we will discuss the relationship between autophagy and aging.","subitem_description_type":"Abstract"}]},"item_10002_full_name_75":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"3933","nameIdentifierScheme":"WEKO"}],"names":[{"name":"INOMATA, MEGUMI"}]},{"nameIdentifiers":[{"nameIdentifier":"4172","nameIdentifierScheme":"WEKO"}],"names":[{"name":"HORIE, SHUN"}]},{"nameIdentifiers":[{"nameIdentifier":"3934","nameIdentifierScheme":"WEKO"}],"names":[{"name":"INTO, TAKESHI"}]}]},"item_10002_radio_89":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_radio_item":"application/pdf"}]},"item_10002_source_id_82":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2433-0191","subitem_source_identifier_type":"ISSN"}]},"item_10002_source_id_84":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053070","subitem_source_identifier_type":"NCID"}]},"item_10002_textarea_76":{"attribute_name":"所属","attribute_value_mlt":[{"subitem_textarea_value":"朝日大学口腔感染医療学講座口腔微生物学分野\nDepartment of Oral Microbiology, Division of Oral Infections and Health Sciences, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学口腔感染医療学講座口腔微生物学分野\nDepartment of Oral Microbiology, Division of Oral Infections and Health Sciences, Asahi University School of Dentistry"},{"subitem_textarea_value":"朝日大学口腔感染医療学講座口腔微生物学分野\nDepartment of Oral Microbiology, Division of Oral Infections and Health Sciences, Asahi University School of Dentistry"}]},"item_10002_version_type_95":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"猪俣, 恵"}],"nameIdentifiers":[{"nameIdentifier":"3930","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000017728337","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000017728337"},{"nameIdentifier":"40553798","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40553798"}]},{"creatorNames":[{"creatorName":"堀江, 俊"}],"nameIdentifiers":[{"nameIdentifier":"4171","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000342906305","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000342906305"}]},{"creatorNames":[{"creatorName":"引頭, 毅"}],"nameIdentifiers":[{"nameIdentifier":"3931","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000004727967","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000004727967"},{"nameIdentifier":"10360918","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10360918"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-11-08"}],"displaytype":"detail","filename":"gifushika451_17_2018.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"gifushika451_17_2018","url":"https://asahi-u.repo.nii.ac.jp/record/9790/files/gifushika451_17_2018.pdf"},"version_id":"2f04a30f-71a8-4933-b318-3e5c337b45d0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"オートファジー","subitem_subject_scheme":"Other"},{"subitem_subject":"老化","subitem_subject_scheme":"Other"},{"subitem_subject":"加齢関連疾患","subitem_subject_scheme":"Other"},{"subitem_subject":"Autophagy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Aging","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Age-related diseases","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"オートファジーと老化の関連性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"オートファジーと老化の関連性"},{"subitem_title":"Relationship Between Autophagy and Aging","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"21","path":["384"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-07"},"publish_date":"2018-11-07","publish_status":"0","recid":"9790","relation_version_is_last":true,"title":["オートファジーと老化の関連性"],"weko_creator_id":"21","weko_shared_id":-1},"updated":"2023-09-15T06:08:53.669722+00:00"}