{"created":"2023-06-23T12:18:59.262700+00:00","id":9794,"links":{},"metadata":{"_buckets":{"deposit":"24759aa1-ae7d-48b8-9a5d-70d26c3201e0"},"_deposit":{"created_by":21,"id":"9794","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"9794"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00009794","sets":["46:348:384"]},"author_link":["4151","4008","13279","4001","4043","4018","609","4408","8881","4042","13280","610","1290","3561","4152","3804","13278"],"item_10002_biblio_info_77":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"47","bibliographicPageStart":"35","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"岐阜歯科学会雑誌"},{"bibliographic_title":"The Journal of Gifu Dental Society","bibliographic_titleLang":"en"}]}]},"item_10002_description_80":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"歯科インプラント治療症例における高度の骨吸収や骨欠損に対し、骨再生療法が行われている。骨再生療法としては骨再生誘導法（Guided Bone Regeneration: GBR）としてメンブレンテクニックが応用されているが骨造成量が多く必要な場合には、自家骨を始めとする骨補填剤が応用される。自家骨を応用する場合はその採取のための手術侵襲や、手術時間の延長などの問題があるため、人工骨補填材料が臨床応用されている3）。人工骨補填材としてはハイドロキシアパタイト（HA）やβ-TricalciumPhosphate（β-TCP）等のリン酸カルシウム系材料が応用されてきた5）しかし、HAは生体親和性に優れるが材料吸収性ではないため、 生体内に残存する6）。また、β-TCPは生体内で吸収され、骨と置換する材料であるが7-9）、含有されている成分の中には生体親和性において問題が指摘されている。このような問題点を改善すべく、DoiらとElliesは生体親和性に優れ、吸収性材料である炭酸含有アパタイト（Carbonated Apatite, CA）を開発した12-13）。そして、その優れた特性を活かした生体応用研究がこれまでに報告されてきた14）。本研究では、 ラット大腿骨を用いた動物実験モデルにおいて焼成温度の異なる（700℃ /500℃）CA顆粒を人工骨補填材料として填入し、組織学的に評価し、さらに、吸着徐放性の検討も併せて行った。実験結果では、500℃焼成と700℃焼成のCAの臨床応用を考慮すると、500℃では生体における材料吸収性が良い反面、骨形成開始や骨成熟に至る期間やCA顆粒の臨床的操作性においては700℃の方が良好であった。以上の結果から臨床応用には700℃焼成のCA顆粒に、骨吸収や骨欠損部に対する人工骨補填材料としての期待ができる。また、CA顆粒とFGF2の併用は、至適濃度等の検討が必要ではあるが、骨形成や骨成熟を促進させることが示されたことから、同様に他の成長因子の併用による有用性も期待される。\nFor severe bone resorption and bone defects at dental implant treatment sites, bone augmentation treatment is required. For bone augmentation treatments such as guided bone regeneration(GBR), the membrane technique is most commonly applied, but bone substitute materials including autogenous bone are used when large quantities of bone are required. However, the collection of autogenous bone requires increased surgical invasiveness, and artificial bone substitute materials have therefore been applied clinically. Calcium phosphate-based materials such as hydroxyapatite(HA) or β-tricalcium phosphate(β-TCP) have been applied as artificial bone substitute materials. Although HA has superior biocompatibility, it remains in the living bone because it is not resorbable. In contrast, β-TCP is resorbable in vivo, as it is replaced with bone, but it has lower biocompatibility. Doi and Ellies reportedly developed Carbonated Apatite(CA), which shows superior biocompatibility and is resorbable, and preliminary studies have reported superior characteristics in the living. In the present animal experiment using rat femur to evaluate differences in sintered temperature (700℃ / 500℃), CA granules were used as an artificial bone substitute material, and were observed histologically for their absorption and controlled release characteristics. The resorbability in the living body was good at 500°C, which we considered to be suitable for clinical application of CA, but 700°C was apparently better for early bone formation and maturity, as well as the clinical maneuverability of CA granules. Based on these results, we concluded that for clinical application of CA granules, preparation at 700℃ is optimal for severe bone resorption and bone defects at the dental implant treatment sites. In addition, the combination of CA granules and FGF-2 requires further study to determine optimal concentrations, and their usefulness in combination with other growth factors is expected because CA granules were shown to\npromote bone formation and bone maturity. 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Augmentation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"GBR","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sustained Release Materials","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"焼成温度の違いによる骨補填材としての炭酸含有アパタイトの臨床的有用性の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"焼成温度の違いによる骨補填材としての炭酸含有アパタイトの臨床的有用性の検討"},{"subitem_title":"Evaluation on Clinical Usefulness of the Sinter Temperature Differences of Carbonate Apatite as Bone substitute","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"21","path":["384"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-07"},"publish_date":"2018-11-07","publish_status":"0","recid":"9794","relation_version_is_last":true,"title":["焼成温度の違いによる骨補填材としての炭酸含有アパタイトの臨床的有用性の検討"],"weko_creator_id":"21","weko_shared_id":-1},"updated":"2024-03-29T09:01:46.046950+00:00"}