{"created":"2023-06-23T12:19:06.163100+00:00","id":9939,"links":{},"metadata":{"_buckets":{"deposit":"3c492adc-86bf-4759-9758-09d073cffcf3"},"_deposit":{"created_by":19,"id":"9939","owners":[19],"pid":{"revision_id":0,"type":"depid","value":"9939"},"status":"published"},"_oai":{"id":"oai:asahi-u.repo.nii.ac.jp:00009939","sets":["64:123"]},"author_link":["13413"],"item_10_creator_30":{"attribute_name":"教員氏名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"引頭, 毅"}],"nameIdentifiers":[{"nameIdentifier":"13413","nameIdentifierScheme":"WEKO"}]}]},"item_10_date_36":{"attribute_name":"発行又は発表の年月","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-08"}]},"item_10_text_37":{"attribute_name":"ISBN","attribute_value_mlt":[{"subitem_text_value":"1932-6203"}]},"item_10_textarea_29":{"attribute_name":"業績分類","attribute_value_mlt":[{"subitem_textarea_value":"学術雑誌論文"}]},"item_10_textarea_31":{"attribute_name":"発行、発表雑誌等、又は発表学会等の名称","attribute_value_mlt":[{"subitem_textarea_value":"PLoS One"}]},"item_10_textarea_32":{"attribute_name":"巻","attribute_value_mlt":[{"subitem_textarea_value":"13"}]},"item_10_textarea_33":{"attribute_name":"号","attribute_value_mlt":[{"subitem_textarea_value":"8"}]},"item_10_textarea_34":{"attribute_name":"掲載ページ","attribute_value_mlt":[{"subitem_textarea_value":"202791-"}]},"item_10_textarea_35":{"attribute_name":"単著、共著の別","attribute_value_mlt":[{"subitem_textarea_value":"共著"}]},"item_10_textarea_42":{"attribute_name":"概要","attribute_value_mlt":[{"subitem_textarea_value":"Porphyromonas gingivalis（Pg）は，宿主の免疫応答を回避する様々な能力を有する歯周病原体である．Pgは外膜タンパク質としてOmpA様タンパク質（OmpALP）を産生するが，本研究ではOmpALP欠損株が血清中で生存できなくなることを見出した．OmpALP欠損株を宿主細胞と共培養すると死菌からLPSが放出されてToll様受容体4を刺激する．野生型株は90％濃度のヒト血清で増殖できるが，OmpALP欠損株は5％でも生存できなかった．一方，OmpALP欠損株は、プロテイナーゼK処理血清中では生存し増殖することができた．以上の結果はOmpALPがPgの血清抵抗性にとって重要であることを示唆している．"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"other","resourceuri":"http://purl.org/coar/resource_type/c_1843"}]},"item_title":"OmpA-like proteins of Porphyromonas gingivalis contribute to serum resistance and prevent Toll-like receptor 4-mediated host cell activation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"OmpA-like proteins of Porphyromonas gingivalis contribute to serum resistance and prevent Toll-like receptor 4-mediated host cell activation"}]},"item_type_id":"10","owner":"19","path":["123"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-01-08"},"publish_date":"2019-01-08","publish_status":"0","recid":"9939","relation_version_is_last":true,"title":["OmpA-like proteins of Porphyromonas gingivalis contribute to serum resistance and prevent Toll-like receptor 4-mediated host cell activation"],"weko_creator_id":"19","weko_shared_id":-1},"updated":"2023-06-23T13:37:59.337936+00:00"}