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Impact of commensal flora on periodontal immune response to lipopolysaccharide
https://asahi-u.repo.nii.ac.jp/records/9956
https://asahi-u.repo.nii.ac.jp/records/995618539c90-cf47-4234-ad45-6cd14ac4f244
| Item type | 朝日大学 教育・研究業績(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-01-08 | |||||
| タイトル | ||||||
| タイトル | Impact of commensal flora on periodontal immune response to lipopolysaccharide | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||
| 資源タイプ | other | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 業績分類 | ||||||
| 値 | 学術雑誌論文 | |||||
| 教員氏名 |
友藤, 孝明
× 友藤, 孝明 |
|||||
| 発行、発表雑誌等、又は発表学会等の名称 | ||||||
| 値 | J Periodontol | |||||
| 巻 | ||||||
| 値 | 89 | |||||
| 号 | ||||||
| 値 | 10 | |||||
| 掲載ページ | ||||||
| 値 | 1213-1220 | |||||
| 単著、共著の別 | ||||||
| 値 | 共著 | |||||
| 発行又は発表の年月 | ||||||
| 日付 | 2018-10 | |||||
| ISSN | ||||||
| 値 | 0022-3492 | |||||
| 概要 | ||||||
| 値 | The purpose of this study was to evaluate the expression of immune responses after topical application of LPS in germ-free (GF) and specific-pathogen-free (SPF) mice. SPF mice, but not GF mice, showed an increased number of CD4+ T cells in the periodontal tissue at 3 hours after LPS application, compared with the number at baseline (p < 0.05). Gene expressions of tumor necrosis factor-α (Tnf-α) and forkhead box protein p3 (Foxp3) was also significantly higher in the SPF mice than in the GF mice at 3 hours after LPS application (p < 0.05). The number of neutrophils peaked at 24 hours in both GF and SPF mice. LPS-exposed SPF mice exhibited increases in the number of CD4+ T cells and in Tnf-α and Foxp3 gene expression in periodontal tissue compared with LPS-exposed GF mice. | |||||
