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Scores of Child–Pugh Classification Impact Overall Survival After Stereotactic Body Radiation Therapy for Primary and Metastatic Liver Tumors
https://asahi-u.repo.nii.ac.jp/records/12127
https://asahi-u.repo.nii.ac.jp/records/12127b6ea3d0f-0f91-4c40-bef5-1b8a0673edf5
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
09736883_inpress_2019 (253.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-05-22 | |||||
| タイトル | ||||||
| タイトル | Scores of Child–Pugh Classification Impact Overall Survival After Stereotactic Body Radiation Therapy for Primary and Metastatic Liver Tumors | |||||
| タイトル | ||||||
| タイトル | Scores of Child–Pugh Classification Impact Overall Survival After Stereotactic Body Radiation Therapy for Primary and Metastatic Liver Tumors | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | biological effective dose | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | hepatocellular carcinoma | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | liver metastasis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | radiotherapy | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | tumor control | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Tanaka, Osamu
× Tanaka, Osamu× Kojima, Takao× Ohbora, Akihiro× Makita, Chiyoko× Taniguchi, Takuya× Ono, Kousei× Matsuo, Masayuki× Nagata, Yasushi |
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| 所属 | ||||||
| Asahi University Hospital, Department of Radiation Oncology | ||||||
| 所属 | ||||||
| Asahi University Hospital, Department of Gastroenterology | ||||||
| 所属 | ||||||
| Asahi University Hospital, Department of Gastroenterology | ||||||
| 所属 | ||||||
| Gifu Prefectural General Medical Center, Department of Radiation Oncology | ||||||
| 所属 | ||||||
| Asahi University Hospital, Department of Radiation Oncology | ||||||
| 所属 | ||||||
| Asahi University Hospital, Department of Radiation Oncology | ||||||
| 所属 | ||||||
| Gifu University Hospital, Department of Radiology | ||||||
| 所属 | ||||||
| Hiroshima University Hospital, Department of Radiation Oncology | ||||||
| 書誌情報 |
en : Journal of Clinical and Experimental Hematopathology |
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| 出版者 | ||||||
| Elsevier | ||||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Background Stereotactic body radiotherapy (SBRT) delivers high-dose radiation to tumor tissues in few fractions, thereby reducing radiation damage to at-risk organs. There are more potential effects of SBRT owing to the higher biological equivalent dose delivered. Herein, we retrospectively analyzed its effectiveness and toxicity at our institution. Methods Data from patients with hepatocellular carcinoma (HCC; n = 10) and liver metastases (n = 10) who underwent SBRT (total dose of 30–50 Gy in 5–10 fractions) between 2013 and 2016 were analyzed. Adverse events were recorded at the end of RT, 6 months after treatment, or upon death. Overall survival (OS) was calculated according to the biological effective dose (BED α/β = 10) and liver function (Child–Pugh [CP] classification 5 or 6 vs. 7 or 8) after SBRT, using Kaplan–Meier analyses. Results Of the 20 patients, 6 declined the CP classification score after SBRT; grade 3 adverse events were not seen in any patient. A higher OS rate was seen in patients receiving a higher BED and in those with better CP classification after SBRT. Kaplan–Meier survival analysis yielded a median OS of 401 days and 1- and 2-year OS of 45% and 15%, respectively. Conclusion The higher BED was significantly associated with tumor control, and there were no differences in the tumor control rate between HCC and metastatic tumors. Changes in CP scores after SBRT also affected the survival rate. Good liver function may permit multiple rounds of SBRT. |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0973-6883 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.jceh.2019.05.002 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/abs/pii/S0973688319301458 | |||||
| 関連名称 | 出版社サイト | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 見出し | ||||||
| 大見出し | in Press | |||||
| 言語 | ja | |||||
