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マウスの遺伝学的背景は口蓋突起内側縁上皮の分解能力とTGFβ3ノックアウトマウスの口蓋裂表現型に影響を及ぼす
https://asahi-u.repo.nii.ac.jp/records/13244
https://asahi-u.repo.nii.ac.jp/records/13244d83045ae-07e9-48a8-bc02-76b0ddea1212
| Item type | 朝日大学 教育・研究業績(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-06-23 | |||||
| タイトル | ||||||
| タイトル | マウスの遺伝学的背景は口蓋突起内側縁上皮の分解能力とTGFβ3ノックアウトマウスの口蓋裂表現型に影響を及ぼす | |||||
| タイトル | ||||||
| タイトル | Genetic background influences the capacity for medial edge epithelium disintegration and phenotype of cleft palate in TGFβ3 knockout mice | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||
| 資源タイプ | other | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 業績分類 | ||||||
| 値 | 研究論文 | |||||
| 教員氏名 |
滝川, 俊也
× 滝川, 俊也 |
|||||
| 発行、発表雑誌等、又は発表学会等の名称 | ||||||
| 値 | Journal of Oral Biosciences | |||||
| 巻 | ||||||
| 値 | 62 | |||||
| 号 | ||||||
| 値 | 3 | |||||
| 掲載ページ | ||||||
| 値 | 260-266 | |||||
| 単著、共著の別 | ||||||
| 値 | 共著 | |||||
| 発行又は発表の年月 | ||||||
| 日付 | 2020-09 | |||||
| 概要 | ||||||
| 値 | We produced TGFβ3 knockout congenic mouse strains with five different genetic backgrounds. The phenotypes of the congenic strains were determined by visual examination. The capacity for disintegration of the medial edge epithelium (MEE) and basement membrane (BM) of palatal shelves of all five mouse strains was analyzed by using immunofluorescence staining after single palatal shelf suspension culture. Although the five congenic strains carried the same defective Tgfb3 gene, the fetal palate phenotypes differed among strains. The loss of the medial edge epithelial (MEE) cells and the basement menbrane (BM) of palate also differed with the genetic background, and the degree of such loss correlated with the cleft palate phenotype. Thus the cleft palate phenotype in mice is influenced by the genetic background, which governs the capacity for MEE and BM disintegration. | |||||
