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A New Insight for the Significance of Myofibroblasts in Human Dilated Cardiomyopathy: Relation with Left Ventricular Wall Stress.
https://asahi-u.repo.nii.ac.jp/records/2362
https://asahi-u.repo.nii.ac.jp/records/23622feabb76-6771-4b53-9c19-33cd807e35bf
| Item type | 朝日大学 教育・研究業績(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-02-20 | |||||
| タイトル | ||||||
| タイトル | A New Insight for the Significance of Myofibroblasts in Human Dilated Cardiomyopathy: Relation with Left Ventricular Wall Stress. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||
| 資源タイプ | other | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 業績分類 | ||||||
| 値 | 学会発表 | |||||
| 教員氏名 |
竹村, 元三
× 竹村, 元三 |
|||||
| 発行、発表雑誌等、又は発表学会等の名称 | ||||||
| 値 | 第78回日本循環器学会総会・学術集会（東京） | |||||
| 単著、共著の別 | ||||||
| 値 | 共同 | |||||
| 発行又は発表の年月 | ||||||
| 日付 | 2014-03-21 | |||||
| 概要 | ||||||
| 値 | Under the mechanical loading, cardiac fibroblasts switch to myofibroblasts which express α-smooth muscle actin (α-SMA). In fibrosing hearts, myofibroblasts are associated with cardiac extracellular matrix remodeling. It is well known that myofibroblasts are increased not only in the scar of post-infarction hearts but also in failing hearts subjected to pressure or volume overload. However, the clinical significance of the myofibroblasts in dilated cardiomyopathy (DCM) is still unclear, which we here investigated using left ventricular (LV) biopsy specimens obtained from 43 DCM patients who were diagnosed in our hospital in 2009 to 2013. Immunohistochemitry for α-SMA demonstrated the bundles of myofibroblasts localizing in the subendocardium in 23 of 43 specimens. These cells were immuno-positive also for desmin, but not for vimentin or fibronectin. Ultrastructurally, the cells contained massive actin filaments, well developed endoplasmic reticulum, and sparse glycogen granules. In the bundles-positive group, the LV peak wall stress (164.1±46.6 vs. 198.7±44.8 dynes⋅103/cm2, p<0.05) and LV end-systolic meridional wall stress (96.5±37.6 vs. 120.3±38.3 dynes⋅103/cm2, p<0.05) were significantly smaller and the ejection fraction was greater (41.1±9.7 vs. 34.6±11.1 %, p<0.05) compared with the bundles-negative group, while the age and the sex were not significantly different between the groups.These results suggest that the bundles of myofibroblasts may be one of the compensatory mechanisms against heart failure, which attenuate wall stress and cardiac remodeling. | |||||
