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hnRNPK is new prospective marker of early detection for tongue carcinogenesis
https://asahi-u.repo.nii.ac.jp/records/2417
https://asahi-u.repo.nii.ac.jp/records/241716f75336-fada-498e-91c5-6527faa25b66
| Item type | 朝日大学 教育・研究業績(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-02-20 | |||||
| タイトル | ||||||
| タイトル | hnRNPK is new prospective marker of early detection for tongue carcinogenesis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||
| 資源タイプ | other | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 業績分類 | ||||||
| 値 | 学会発表 | |||||
| 教員氏名 |
中尾, 寿奈
× 中尾, 寿奈 |
|||||
| 発行、発表雑誌等、又は発表学会等の名称 | ||||||
| 値 | 第103回日本病理学会 | |||||
| 単著、共著の別 | ||||||
| 値 | 共同 | |||||
| 発行又は発表の年月 | ||||||
| 日付 | 2014-04 | |||||
| 概要 | ||||||
| 値 | (概要)We have reported that heterogeneous nuclear ribonucleoprotein K was associated with a pre-malignant state during 4-nitroquinoline 1-oxide induced rat tongue carcinogenesis. In this study, to investigate whether this gene is also associated to the human oral cancer, we focused on the hnRNP K gene and examined the relationship between mRNA expressions and the hyperplasia, epithelial dysplasia and SCC samples. We analyzed the expressions of hnRNP K using by immunohistochemistry and RT-PCR. These results showed that the level of hnRNP K mRNA and protein were significantly altered in Dys and SCC samples compared to the normal epithelium. The immunohistochemical expression of hnRNP K was 2-holds higher in the Hyp, Dys and SCC. The hnRNP K mRNA expression level also was 3-holds higher in the Hyp, Dys and SCC. These data suggest that this marker could be for the early detection of pre-malignant lesion of oral cancer. | |||||
